1,5,5,6-tetramethyl-cyclohexene | 3757-05-9

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 1,5,5,6-tetramethyl-cyclohexene
• 英文别名: 1,5,5,6-Tetramethyl-cyclohexen；α-Methylcyclogeraniolen；1,5,5,6-Tetramethylcyclohexen；2,3,4,4-Tetramethylcyclohexene；1,5,5,6-tetramethylcyclohexene
• CAS: 3757-05-9
• 化学式: C₁₀H₁₈
• 分子量: 138.253
• InChiKey: YYCKFNKCDOJUSP-UHFFFAOYSA-N

物化性质

• 沸点：
  168-170 °C(Press: 70 Torr)
• 密度：
  0.8325 g/cm3(Temp: 0 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  squalene 生成 1,5,5,6-tetramethyl-cyclohexene
  参考文献：
  名称：

  Majima; Kubota, vol. 1, p. 29,31

  摘要：

  DOI：

文献信息

• Evidence for a novel mechanism of the 1,2-bond shift rearrangements catalysed by coenzyme-B12
  作者：Robert Hamilton、Thomas R. B. Mitchell、Edward A. McIlgorm、John J. Rooney、M. Anthony McKervey

  DOI：10.1039/c39810000686

  日期：——

  6-tetramethyl-cyclohex-1-yl toluene-p-sulphonate to (PPh3)2CoBr2,(PPh3)2NiBr2, and hydroxo-cobalamin, all reduced with sodium borohydride, or to (Me)2CuLi, provide firm evidence for a novel mechanism of the 1,2-bond shift rearrangements catalysed by vitamin B12 coenzyme.

  在环境温度为2,2,6,6-四甲基-环己-1-基甲苯-对磺酸盐氧化成（PPh 3）2 CoBr 2，（PPh 3）2 NiBr 2和均被硼氢化钠还原或还原为（Me）2 CuLi的羟钴胺素，为维生素B 12辅酶催化的1,2-键移位重排的新机理提供了有力的证据。
• Etudes sur les mati�res v�g�tales volatiles CXCV Sur les ?- et ?-m�thylcyclog�raniol�nes
  作者：Yves-Ren� Naves

  DOI：10.1002/hlca.19640470720

  日期：——

  The α-methyl- and β-methylcyclogeraniolenes, isolated by vapor-phase prepararative chromatography from the cyclisation products of dihydromyrcenes are described. Evidence, by NMR. and IR. spectroscopy, is presented for their structures. The γ-methylcyclogeraniolene is present in the cyclisation products to a very small extent if present at all.

  描述了通过气相制备色谱法从二氢月桂烯的环化产物中分离的α-甲基-和β-甲基环geraniolenes。通过NMR的证据。在你身上。光谱，介绍了它们的结构。如果存在，则γ-甲基环香叶烯在环化产物中的存在量很小。
• Dupont; Dulou; Desreux, Bulletin de la Societe Chimique de France, 1939, vol. <5>6, p. 84
  作者：Dupont、Dulou、Desreux

  DOI：——

  日期：——
• DNA adducts and human atherosclerotic lesions
  作者：Blanka Binková、Přemysl Strejc、Otta Boubelík、Zdena Stávková、Irena Chvátalová、Radim J. Šrám

  DOI：10.1078/1438-4639-00072

  日期：——

  It has been hypothesized that mutational events may be involved in the atherogenetic process and that at least a portion of atherosclerotic plaques may be the results of monoclonal proliferation of a single mutated smooth muscle cell (SMC). Therefore, atherosclerosis may be similar to carcinogenesis and may have an environmental etiology. We have analyzed bulky-aromatic DNA adducts in human thoracic aortas from mate subjects, aged between 30-60 years, who died suddenly or accidentally, and who had been examined by autopsy within 24 h after death. We found significantly (P < 0.001) higher DNA adduct levels in the samples from subjects with frequent atherosclerotic changes in the whole body ("Cases", N = 76) compared with those having few atherosclerotic changes ("Controls", N = 57). We also observed a significantly elevated weight of heart and plasma levels of total and LDL cholesterol in "Cases" vs "Controls". Significant differences in DNA adduct levels between smokers and nonsmokers were observed in "Controls" only. Multivariate linear regression analyses with age-adjusted data confirmed a significant influence of LDL cholesterol (P < 0.001), vitamin A (P < 0.01), smoking behavior (P < 0.05; evaluated as plasma cotinine levels) and NAT2 genotypes (P < 0.05) on bulky-aromatic DNA adduct levels. The induction of DNA adducts suggests that alterations at the DNA level may contribute to the development of atherosclerosis. Furthermore, atherogenesis and carcinogenesis may share a similar etiology, i.e. genotoxic action of environmental chemicals.
• Kirmse, Wolfgang; Spaleck, Walter, Angewandte Chemie, 1981, vol. 93, # 9, p. 791 - 792
  作者：Kirmse, Wolfgang、Spaleck, Walter

  DOI：——

  日期：——