2-O-α-L-fucopyranosyl-D-galactose | 419536-65-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-O-α-L-fucopyranosyl-D-galactose
• 英文别名: α-L-Fuc-(1→2)-D-Gal；2-O-(6-deoxy-alpha-L-galactopyranosyl)-D-galactopyranose；(2S,3S,4R,5S,6S)-2-methyl-6-[(3R,4S,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
• CAS: 419536-65-5
• 化学式: C₁₂H₂₂O₁₀
• 分子量: 326.301
• InChiKey: VSRVRBXGIRFARR-QEOJKCTASA-N

物化性质

• 沸点：
  633.9±55.0 °C(Predicted)
• 密度：
  1.66±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1,6-anhydro-2-O-(2,3,4-tri-O-benzyl-α,β-L-fucopyranosyl)-β-D-galactopyranose 在 palladium on activated charcoal 氢气 、 sodium methylate 作用下， 以 吡啶 、 甲醇 、 三氟乙酸 为溶剂， 反应 2.0h， 生成 2-O-α-L-fucopyranosyl-D-galactose
  参考文献：
  名称：

  Synthesis of the H-disaccharide (2-O-α-l-fucopyranosyl-d-galactose) via the trichloroacetimidate method

  摘要：

  DOI：

  10.1016/0008-6215(88)80026-0

文献信息

• NOVEL CARBOHYDRATE FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF
  申请人：Laine Jarmo

  公开号：US20100028913A1

  公开（公告）日：2010-02-04

  The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.

  该发明描述了用于特定结合干细胞糖基结构的试剂和方法。此外，该发明还涉及筛选其他结合试剂，以针对干细胞表面上的特定糖基表位。优选的糖基结构结合物包括蛋白质，如酶，凝集素和抗体。
• Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof
  申请人：Satomaa Tero

  公开号：US20100055710A1

  公开（公告）日：2010-03-04

  The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.

  本发明描述了从人类多能干细胞中生产新型糖基化合物（糖基组）的方法。本发明还涉及修改糖基组的方法以及糖基组和修改后的糖基组的分析方法。此外，本发明还涉及携带修改后糖基组的干细胞。
• NOVEL METHODS AND REAGENTS DIRECTED TO PRODUCTION OF CELLS
  申请人：Laine Jarmo

  公开号：US20100068806A1

  公开（公告）日：2010-03-18

  The present invention provides methods and materials to modulate and grow stem cells by contacting stem cells with a binder recognizing terminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also useful to screen such a binding agents and binders.

  本发明提供了一种通过将干细胞与识别干细胞末端糖基结构的结合物接触来调节和生长干细胞的方法和材料。调节可以是形态学变化、分化状态的改变、生物状态的改变或附着性的改变。本发明提供的材料也可用于筛选这种结合剂和结合物。
• Regioselective synthesis of α-l-fucosyl-containing disaccharides by use of α-l-fucosidases of various origins
  作者：Katsumi Ajisaka、Mayumi Shirakabe

  DOI：10.1016/0008-6215(92)84115-9

  日期：1992.2