ammonium thiocyanate | 28241-61-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫氰酸盐
• 英文名称: ammonium thiocyanate
• 英文别名: ammonia thiocyanic acid；Aminothiocyanate；amino thiocyanate
• CAS: 28241-61-4
• 化学式: CH₂N₂S
• 分子量: 74.1063
• InChiKey: FCVPQJRQZFMXTM-UHFFFAOYSA-N

物化性质

• 沸点：
  161.5±23.0 °C(Predicted)
• 密度：
  1.321±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ammonium thiocyanate 在 硫酸 、 一水合肼 作用下， 以 水 为溶剂， 反应 3.0h， 生成 2,5-二硫代联二脲
  参考文献：
  名称：

  Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: Derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety

  摘要：

  A series of novel 1,3,4-thiadiazole derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety were synthesized by the method of splicing active substructures. Among these derivatives, compounds 12,13,15-22 and 24-31 were firstly reported. All the compounds were assayed for antimicrobial activities against five fungi strains and four bacteria strains. The preliminary results indicated that compounds 25 and 28-31 showed good antifungal activities against Physaclospora piricola and Rhizoctonia solani. Compound 26 exhibited good antifungal activities against Cercospora beticola and R. solani. Most of the compounds showed better antibacterial activities against Gram-negative bacteria strains than Gram-positive bacteria strains. Compounds 25 and 28 showed the best activities against Pseudomonas fluorescence while compounds 30-31 showed good activities against Escherichia coli. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.04.014
• 作为产物：
  描述：

  sodium chlorite 生成 ammonium thiocyanate
  参考文献：
  名称：

  AQUEOUS COMPOSITION AND METHOD OF PRODUCING CHLORINE DIOXIDE USING AQUEOUS COMPOSITION

  摘要：

  一种水性组合物包括一个活化剂、一个亚氯酸盐离子源和水。该水性组合物呈碱性。该水性组合物在与酸接触时产生二氧化氯。生产二氧化氯的方法包括将水性组合物与酸接触。

  公开号：

  US20180179058A1
• 作为试剂：
  描述：

  1,2-环氧辛烷 在 5,10,15,20-tetra(pentafluorophenyl)porphyrin Fe(III) 、 ammonium thiocyanate 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以95%的产率得到2-hexyl thiirane
  参考文献：
  名称：

  Iron(III) 5,10,15,20-Tetrakis (pentafluorophenyl)porphyrin as an Efficient Catalyst for Conversion of Epoxides to Thiiranes

  摘要：

  铁（III）5,10,15,20-四（五氟苯基）卟啉（Fe(TF5PP)Cl）是一种新型催化剂，可在硫氰酸铵存在下将环氧化物转化为相应的硫环。

  DOI：

  10.1039/a807196i

文献信息

• [EN] 4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS<br/>[FR] DÉRIVÉS DE 4-PHÉNYL-N-(PHÉNYL)THIAZOL-2-AMINE ET COMPOSÉS ASSOCIÉS UTILISÉS COMME AGONISTES DU RÉCEPTEUR D'HYDROCARBURE ARYLE (AHR) POUR LE TRAITEMENT, PAR EX., DE TROUBLE LIÉS À L'ANGIOGENÈSE OU INFLAMMATOIRES
  申请人：IKENA ONCOLOGY INC

  公开号：WO2021127301A1

  公开（公告）日：2021-06-24

  4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders.

  4-苯基-N-(苯基)噻唑-2-胺和4-(吡啶-3-基)-N-(苯基)噻唑-2-胺衍生物以及相应的噻二唑、噻吩、噁唑、噁二唑、咪唑和三唑衍生物和相关化合物作为芳香烃受体（AHR）激动剂，用于治疗涉及血管生成的疾病，例如视网膜病变、银屑病、类风湿性关节炎、肥胖和癌症，或炎症性疾病。
• N-[4-(Heteroarylmethyl)phenyl]-heteroarylamines
  申请人：Janssen-Cilag S.A.

  公开号：US06124330A1

  公开（公告）日：2000-09-26

  The present invention is concerned with compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R.sup.1 is hydrogen, hydroxy, C.sub.1-6 alkyl or aryl; R.sup.2 is hydrogen; optionally substituted C.sub.1-12 alkyl; C.sub.3-7 cycloalkyl; C.sub.2-8 alkenyl, optionally substituted pyrrolidinyl or aryl; R.sup.3 is hydrogen, optionally substituted C.sub.1-6 alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; ##STR2## is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.

  本发明涉及以下结构的化合物：##STR1## 其N-氧化物、药学上可接受的加合盐及其立体化异构体形式，其中R.sup.1为氢、羟基、C.sub.1-6烷基或芳基；R.sup.2为氢；可选择取代的C.sub.1-12烷基；C.sub.3-7环烷基；C.sub.2-8烯基，可选择取代的吡咯烷基或芳基；R.sup.3为氢，可选择取代的C.sub.1-6烷基或芳基；Het为从咪唑基、三唑基、四唑基和吡啶基中选择的可选择取代的不饱和杂环；##STR2## 为可选择取代的不饱和单环或双环杂环；芳基为可选择取代的苯基。本发明还涉及其制备方法和包含所述新化合物的组合物，以及它们作为药物的用途。
• [EN] HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES ET INFECTIONS HELMINTHIQUES
  申请人：CELGENE CORP

  公开号：WO2022087326A1

  公开（公告）日：2022-04-28

  Provided herein are Heterocyclic Compounds of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, compositions comprising an effective amount of a Heterocyclic Compound of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and methods for treating or preventing animal and human filarial worm infections and diseases.

  本文提供了公式(I)、公式(II)、公式(III)、公式(IIIa)、公式(Mb)、公式(IIIc)、公式(Hid)、公式(IV)、公式(IVa)、公式(IVb)和公式(IVc)的杂环化合物，以及其药学上可接受的盐、互变异构体、同位素拓扑异构体和立体异构体，包含有效量的公式(I)、公式(II)、公式(III)、公式(IIIa)、公式(Mb)、公式(IIIc)、公式(Hid)、公式(IV)、公式(IVa)、公式(IVb)和公式(IVc)的杂环化合物的组合物，以及用于治疗或预防动物和人类丝虫感染和疾病的方法。
• N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
  申请人：——

  公开号：US20030176419A1

  公开（公告）日：2003-09-18

  The present invention is concerned with compounds of formula 1 the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is hydrogen, hydroxy, C 1-6 alkyl or aryl; R 2 is hydrogen; optionally substituted C 1-12 alkyl; C 3-7 cycloalkyl; C 2-8 alkenyl, optionally substituted pyrrolidinyl or aryl; R 3 is hydrogen, optionally substituted C 1-6 alklyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; 2 is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.

  本发明涉及公式1的化合物，其N-氧化物，药学上可接受的加成盐和立体化学异构体形式，其中R1为氢，羟基，C1-6烷基或芳基；R2为氢；可选取代的C1-12烷基；C3-7环烷基；C2-8烯基，可选取代的吡咯烷基或芳基；R3为氢，可选取代的C1-6烷基或芳基；Het为可选取代的未饱和杂环，选自咪唑基，三唑基，四唑基和吡啶基；2为可选取代的未饱和单环或双环杂环；芳基为可选取代的苯基。本发明还涉及其制备方法和包含上述新化合物的组合物，以及它们作为药物的用途。
• N-&lsqb;4-(heteroarylmethyl)phenyl&rsqb;-heteroarylamines
  申请人：Janssen Pharmaceutica N.V.

  公开号：US06486187B1

  公开（公告）日：2002-11-26

  The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R3 is hydrogen, optionally substituted C1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.

  本发明涉及公式N-氧化物化合物，其药学上可接受的加合盐和立体化学异构体形式，其中R1为氢、羟基、C1-6烷基或芳基；R2为氢；可选取代的C1-12烷基；C3-7环烷基；C2-8烯基，可选取代的吡咯烷基或芳基；R3为氢、可选取代的C1-6烷基或芳基；Het为可选取代的未饱和杂环，选自咪唑基、三唑基、四唑基和吡啶基；是可选取代的未饱和单环或双环杂环；芳基为可选取代的苯基。本发明还涉及它们的制备方法和包含所述新化合物的组合物，以及它们作为药物的用途。