2,3,3,3-tetrachloro-propan-1-ol | 59778-03-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 2,3,3,3-tetrachloro-propan-1-ol
• 英文别名: 2,3,3,3-Tetrachlor-propan-1-ol；3,3,3,2-Tetrachlor-propanol-(1)；2,3,3,3-Tetrachlor-propanol；2,3,3,3-Tetrachloro-1-propanol；2,3,3,3-tetrachloropropan-1-ol
• CAS: 59778-03-9
• 化学式: C₃H₄Cl₄O
• 分子量: 197.876
• InChiKey: OYLBOCNBDUEVLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,3,3-tetrachloro-propan-1-ol 在 sodium hydroxide 作用下， 生成 2,3,3-三氯-2-丙烯-1-醇
  参考文献：
  名称：

  Prins, Recueil des Travaux Chimiques des Pays-Bas, 1953, vol. 72, p. 867,871

  摘要：

  DOI：
• 作为产物：
  描述：

  3,3-二氯丙-2-烯-1-醇 在 盐酸 、 水 作用下， 生成 2,3,3,3-tetrachloro-propan-1-ol
  参考文献：
  名称：

  Freidlina et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1956, p. 1202,1204;engl.Ausg.S.1229,1231

  摘要：

  DOI：

文献信息

• When Should Densitometry Be Repeated in Healthy Peri- and Postmenopausal Women: The Danish Osteoporosis Prevention Study
  作者：B. Abrahamsen、N. Nissen、A. P. Hermann、B. Hansen、O. Bärenholdt、P. Vestergaard、C. L. Tofteng、S. Pors Nielsen

  DOI：10.1359/jbmr.2002.17.11.2061

  日期：——

  Intervention should be considered in postmenopausal women with bone mineral density (BMD) ≥1 SD below the reference (T or Z score < −1). However, it is unclear when densitometry should be repeated. This study aimed at determining the need for repeat DXA within 5 years in untreated peri‐/postmenopausal women to detect declines of T or Z score to below −1 with 85% confidence. A cohort of 925 healthy women (aged 51.2 ± 2.9 years) were followed within the Danish Osteoporosis Prevention Study (DOPS) for 5 years without hormone‐replacement therapy (HRT). DXA of spine, hip, and forearm was done at 0,1, 2, 3, and 5 years (Hologic QDR‐1000/2000). The annual loss in SD units was 0.12 ± 0.10 at the spine (1.3%), 0.10 ± 0.09 at the femoral neck (1.2%), and 0.07 ± 0.09 at the ultradistal (UD) forearm (1.0%). Accordingly, T scores below −1 developed earlier at the spine. The need for a future DXA scan to predict declines of T and Z scores below −1 depended strongly on baseline BMD. In subjects with a positive T score, the risk of developing T < −1 remained at <15% for 5 years at all measured sites. A new scan was needed after 1 year if the T score was below −0.5, and after 3 years if the T score was between 0 and −0.5. Slightly longer intervals apply if Z scores are used. Follow‐up densitometry in untreated women should be individually targeted from baseline BMD rather than scheduled at fixed time intervals. An algorithm for planning repeat densitometry in perimenopausal women is provided.

  对于骨矿物质密度 (BMD) 低于参考值≥1 SD（T 或 Z 评分 < -1）的绝经后妇女，应考虑进行干预。然而，尚不清楚何时应重复密度测定。本研究旨在确定未经治疗的围绝经期/绝经后妇女是否需要在 5 年内重复 DXA，以检测 T 或 Z 评分下降至低于 -1 的情况，置信度为 85%。丹麦骨质疏松症预防研究 (DOPS) 对 925 名健康女性（年龄 51.2 ± 2.9 岁）进行了为期 5 年的随访，未进行激素替代治疗 (HRT)。脊柱、髋部和前臂的 DXA 在第 0、1、2、3 和 5 年进行（Hologic QDR-1000/2000）。 SD 单位的年度损失在脊柱处为 0.12 ± 0.10 (1.3%)，在股骨颈处为 0.10 ± 0.09 (1.2%)，在超远端 (UD) 前臂处为 0.07 ± 0.09 (1.0%)。因此，低于-1的T分数在脊柱中较早出现。未来是否需要进行 DXA 扫描来预测 T 和 Z 分数下降至 -1 以下，很大程度上取决于基线 BMD。在 T 评分为阳性的受试者中，所有测量部位发生 T < -1 的风险在 5 年内保持在 <15%。如果 T 评分低于 -0.5，则需要在 1 年后进行新的扫描；如果 T 评分在 0 至 -0.5 之间，则需要在 3 年后进行新的扫描。如果使用 Z 分数，则适用稍长的间隔。未经治疗的女性的后续密度测定应根据基线 BMD 单独进行，而不是按固定时间间隔安排。提供了一种用于计划围绝经期妇女重复密度测定的算法。
• Neunhoeffer,O.; Spange,A., Justus Liebigs Annalen der Chemie, 1960, vol. 632, p. 22 - 27
  作者：Neunhoeffer,O.、Spange,A.

  DOI：——

  日期：——
• PESTICIDAL COMPOSITION AND METHOD FOR CONTROLLING A PEST
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2139340A2

  公开（公告）日：2010-01-06
• Organic Electronic Devices Prepared Using Decomposable Polymer Additives
  申请人：Hawker Craig J.

  公开号：US20120168728A1

  公开（公告）日：2012-07-05

  A method of fabricating an organic device is provided comprising providing a first solution comprising an organic semiconductor or a precursor thereof; a solvent and a decomposable polymer additive, where the polymer additive is heated so that it decomposes into gas. The method is applicable to large scale fabrication of OLEDs, OPVs and OFET devices.
• Process for manufacture of 2,3-dichloro-1,1,1-trifluoropropane
  申请人：Fujian Yongjing Technology Co., Ltd

  公开号：US20220144730A1

  公开（公告）日：2022-05-12

  The present invention pertains to a novel process of manufacturing the compound 2,3,3,3-tetrafluoropropene (1234yf). The compound 1234yf is the newest refrigerant with zero OPD (Ozone Depleting Potential) and zero GWP (Global Warming Potential). Thus, the invention relates to a process, involving a carbene generation route, for the manufacture of the compound 2,3,3,3-tetrafluoropropene (1234yf), of the compound 243db (2,3-dichloro-1,1,1-trifluoropropane), and optionally of the compound 2-chloro-1,1,1-trifluoropropene (1233xf) via carbene route and compound 243db (2,3-dichloro-1,1,1-trifluoropropane). The invention also relates to a process for the manufacture of the compound 2,3,3,3-tetrafluoropropene (1234yf), wherein the compound 243db (2,3-dichloro-1,1,1-trifluoropropane) serves as a starting material, for the manufacture of the compound 2,3,3,3-tetrafluoropropene (1234yf). Further, the invention relates to a process for the manufacture of the compound 2,3,3,3-tetrafluoropropene (1234yf), and of the compound 243db (2,3-dichloro-1,1,1-trifluoropropane), the initial starting materials are selected from the group consisting of com-pound 123 (2,2-dichloro-1,1,1-trifluoroethane), compound 124 (2-chloro-1,1,1,2-tetrafluoroethane), and compound 125 (pentafluoroethane).