N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-aniline; sulfate | 84803-70-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-aniline; sulfate
• 英文别名: N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-anilin; Sulfat；Sulfat vom F:166grad；Antazoline Sulfate；N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;sulfuric acid
• CAS: 84803-70-3
• 化学式: C₁₇H₁₉N₃*H₂O₄S
• 分子量: 363.437
• InChiKey: UWOSJBSLQYMGDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0386960A2

  公开（公告）日：1990-09-12

  There is provided a pharmaceutical composition which comprises an aqueous vehicle, a compound having reversible thermosetting gel properties and a compound having film-forming properties. Depending on the relative proportions of these components, the composition can be adapted to function either as a vehicle for delivering pharmacologically or diagnostically active compounds to a human or animal patient and/or as a wound dressing composition.

  本发明提供了一种药物组合物，它包括一种水性载体、一种具有可逆热固性凝胶特性的化合物和一种具有成膜特性的化合物。根据这些成分的相对比例，该组合物既可用作向人类或动物患者输送药理或诊断活性化合物的载体，也可用作伤口敷料组合物。
• Materials useful in human and veterinary medicine
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0481600A2

  公开（公告）日：1992-04-22

  There is provided a solid material useful in medicine, especially a film material for use as a wound dressing or as a drug delivery vehicle, which comprises a molecular mixture of (a) a compound which has film-forming properties, for example hydroxyethylcellulose, hydroxypropylmethylcellulose or polyvinyl alcohol, and (b) a polyoxyethylene-polyoxypropylene block copolymer or a tetrasubstituted derivative of ethylene-diamine in which the substituents are block copolymers of polyoxyethylene-polyoxypropylene, as a modifier. The molecular mixture may be formed, for example, by evaporating a solution of the two components (a) and (b) in a solvent, or by cooling a liquid composition comprising at least one of components (a) and (b) in molten form from an elevated temperature.

  本发明提供了一种用于医药的固体材料，特别是一种用作伤口敷料或给药载体的薄膜材料，它包括以下物质的分子混合物：(a) 一种具有成膜特性的化合物，例如羟乙基纤维素、羟丙基甲基纤维素或聚乙烯醇，以及(b) 聚氧乙烯-聚氧丙烯嵌段共聚物或乙烯-二甲基纤维素的四代衍生物、(b) 作为改性剂的聚氧乙烯-聚氧丙烯嵌段共聚物或乙二胺的四取代衍生物，其中的取代基为聚氧乙烯-聚氧丙烯嵌段共聚物。分子混合物可通过以下方式形成：例如，蒸发两种组分（a）和（b）在溶剂中的溶液，或从高温下冷却包含至少一种熔融状态组分（a）和（b）的液体组合物。
• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。
• Systems, Methods, and Devices for Rehabilitation of Auditory System Disorders Using Pharmaceutical Agents and Auditory Devices
  申请人：Hanley Peter J.

  公开号：US20110245235A1

  公开（公告）日：2011-10-06

  The present inventions provide combination therapies, kits, and methods for providing relief and/or for improving one or more symptoms associated with an auditory system disorder in a subject diagnosed with the auditory system disorder, comprising an effective amount of at least one pharmaceutical agent and at least one auditory system disorder device, as well as methods for using at least one pharmaceutical agent and/or at least one auditory system disorder device in the manufacture of said kits.