1,2:3,6-dianhydro-4,5-O-isopropylidene-1-thio-1-deoxy-D-mannitol | 1333479-54-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2:3,6-dianhydro-4,5-O-isopropylidene-1-thio-1-deoxy-D-mannitol
• 英文别名: (3aR,4S,6aR)-2,2-dimethyl-4-[(2S)-thiiran-2-yl]-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole
• CAS: 1333479-54-1
• 化学式: C₉H₁₄O₃S
• 分子量: 202.274
• InChiKey: LFUDXGMBASOUFG-WCTZXXKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2:3,6-dianhydro-4,5-O-isopropylidene-1-thio-1-deoxy-D-mannitol 、 2,4-二硝基咪唑 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 0.25h， 以25%的产率得到(2R)-2,3-dihydro-2-(2',3'-O-isopropylidene-α-D-erythrofuranosyl)-6-nitroimidazo[2,1-b]thiazole
  参考文献：
  名称：

  Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents

  摘要：

  Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25-12.5 mu g/mL against Mycobacterium tuberculosis H(37)Rv. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.05.034
• 作为产物：
  描述：

  异山梨醇 在 三甲基氯硅烷 、 sodium hydride 、 硫脲 、 sodium iodide 作用下， 以 1,4-二氧六环 、 甲醇 、 乙腈 、 mineral oil 为溶剂， 生成 1,2:3,6-dianhydro-4,5-O-isopropylidene-1-thio-1-deoxy-D-mannitol
  参考文献：
  名称：

  Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents

  摘要：

  Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25-12.5 mu g/mL against Mycobacterium tuberculosis H(37)Rv. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.05.034

文献信息

• Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents
  作者：G. Mugunthan、Dharmarajan Sriram、Perumal Yogeeswari、K.P. Ravindranathan Kartha

  DOI：10.1016/j.carres.2011.05.034

  日期：2011.9

  Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25-12.5 mu g/mL against Mycobacterium tuberculosis H(37)Rv. (C) 2011 Elsevier Ltd. All rights reserved.