1-chloro-2,5,8-trioxadecane | 85232-17-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-chloro-2,5,8-trioxadecane
• 英文别名: 1-[2-(Chloromethoxy)ethoxy]-2-ethoxyethane
• CAS: 85232-17-3
• 化学式: C₇H₁₅ClO₃
• 分子量: 182.647
• InChiKey: YEBQQWOZZPZSQP-UHFFFAOYSA-N

物化性质

• 沸点：
  219.5±20.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-chloro-2,5,8-trioxadecane 在 K/Na 、 N,N-二异丙基乙胺 作用下， 以 乙二醇二甲醚 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 4-methoxy-4''-(1,3,6,9-tetraoxaundecyl)-1,1':4',1''-terbicyclo<2.2.2>octane
  参考文献：
  名称：

  The di-.pi.-methane rearrangement. 226. Molecular rods: synthesis and properties

  摘要：

  Our earlier synthetic methodology affording bicyclo[2.2.2]octyl [1]-rod and [2]-rod systems proved inadequate for [41-rods. New synthetic approaches were developed, and [3]- and [41-rod molecules were obtained. Sodium-potassium coupling was employed to afford the longer rod units. A radical anion approach gave lower yields. Hybrid rods with aromatic rings interposed were also synthesized. Rods of 9.2-, 9.7-, 13.4-, 13.9-, and 18.2-angstrom length were included in this study. Consideration of rod chirality suggests each bicyclooctane rod unit to be stereogenic, either P (clockwise) or M (anticlockwise). Thus, in a [1]-rod there are enantiomers and in a [2]-rod there are diastereomers. Molecular mechanics treatment of rod stereoisomerization was carried out. Interconversion of enantiomers of the [l]-rod and diastereomers of the [n]-rods should be very rapid at room temperature. X-ray analysis of the 4,4'-dimethoxy-[2]-rod reveals an achiral conformation. AMI quantum mechanics computations were carried out on [n]-rod radical cations and bridgehead cations.

  DOI：

  10.1021/jo00046a034
• 作为产物：
  描述：

  聚合甲醛 、 二乙二醇乙醚 在 盐酸 作用下， 反应 3.25h， 生成 1-chloro-2,5,8-trioxadecane
  参考文献：
  名称：

  Preparation of Alkoxymethyl and Alkoxyethoxymethyl Derivatives of Acylanilines using Polyethylene Glycols as Phase Transfer Catalysts

  摘要：

  DOI：

  10.1055/s-1982-30008

文献信息

• ZUPANCIC, B. G.;SOPCIC, M., SYNTHESIS, BRD, 1982, N 11, 942-944
  作者：ZUPANCIC, B. G.、SOPCIC, M.

  DOI：——

  日期：——
• MICROGEL PARTICLES FOR THE DELIVERY OF BIOACTIVE MATERIALS
  申请人：The Regents of the University of California

  公开号：EP1490083A1

  公开（公告）日：2004-12-29
• [EN] MICROGEL PARTICLES FOR THE DELIVERY OF BIOACTIVE MATERIALS<br/>[FR] PARTICULES DE MICROGEL POUR L'ADMINISTRATION DE MATIERES BIOACTIVES
  申请人：UNIV CALIFORNIA

  公开号：WO2003082316A1

  公开（公告）日：2003-10-09

  Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.
• The di-.pi.-methane rearrangement. 226. Molecular rods: synthesis and properties
  作者：Howard E. Zimmerman、Russell K. King、Michael B. Meinhardt

  DOI：10.1021/jo00046a034

  日期：1992.9

  Our earlier synthetic methodology affording bicyclo[2.2.2]octyl [1]-rod and [2]-rod systems proved inadequate for [41-rods. New synthetic approaches were developed, and [3]- and [41-rod molecules were obtained. Sodium-potassium coupling was employed to afford the longer rod units. A radical anion approach gave lower yields. Hybrid rods with aromatic rings interposed were also synthesized. Rods of 9.2-, 9.7-, 13.4-, 13.9-, and 18.2-angstrom length were included in this study. Consideration of rod chirality suggests each bicyclooctane rod unit to be stereogenic, either P (clockwise) or M (anticlockwise). Thus, in a [1]-rod there are enantiomers and in a [2]-rod there are diastereomers. Molecular mechanics treatment of rod stereoisomerization was carried out. Interconversion of enantiomers of the [l]-rod and diastereomers of the [n]-rods should be very rapid at room temperature. X-ray analysis of the 4,4'-dimethoxy-[2]-rod reveals an achiral conformation. AMI quantum mechanics computations were carried out on [n]-rod radical cations and bridgehead cations.
• Preparation of Alkoxymethyl and Alkoxyethoxymethyl Derivatives of Acylanilines using Polyethylene Glycols as Phase Transfer Catalysts
  作者：Boris Zupančič、Mirko Sopčič

  DOI：10.1055/s-1982-30008

  日期：——