3-(2-(2-Ethoxyethoxy)ethoxy)propan-1-amine | 26383-45-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-(2-Ethoxyethoxy)ethoxy)propan-1-amine
• 英文别名: 3-[2-(2-ethoxyethoxy)ethoxy]propan-1-amine
• CAS: 26383-45-9
• 化学式: C₉H₂₁NO₃
• mdl: MFCD00047974
• 分子量: 191.271
• InChiKey: DFAIOPNYWLGZTO-UHFFFAOYSA-N

物化性质

• 沸点：
  261.8±20.0 °C(Predicted)
• 密度：
  0.957±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-(2-Ethoxyethoxy)ethoxy)propan-1-amine 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 N,N'-Bis-{3-[2-(2-ethoxy-ethoxy)-ethoxy]-propyl}-ethane-1,2-diamine
  参考文献：
  名称：

  Aldose epimerization by Ni(II): effect of ether-containing alkylenediamine ligands

  摘要：

  Several N-substituted ethylenediamine (en) Ni(II) derivatives containing ether linkages were prepared in order to study the effect of ligand structure on C-2 epimerization of aldohexoses. The reagent consisted of a Ni(II)-alkylenediamine derivative in methanol. The presence of ether linkages in the ligand increased the solubility of the complexes, and resulted in an increase in the rate of epimerization. Epimerization occured rapidly under mild conditions, and the same equilibrium point was reached regardless of whether the reaction was started from glucose or mannose. Among the ligands studied, N,N'-dialkylethyl-enediamine was the most active in C-2 epimerization.

  DOI：

  10.1016/0008-6215(91)80165-j
• 作为产物：
  描述：

  二乙二醇乙醚 在 Ni(Raney) 氢气 作用下， 生成 3-(2-(2-Ethoxyethoxy)ethoxy)propan-1-amine
  参考文献：
  名称：

  Aldose epimerization by Ni(II): effect of ether-containing alkylenediamine ligands

  摘要：

  Several N-substituted ethylenediamine (en) Ni(II) derivatives containing ether linkages were prepared in order to study the effect of ligand structure on C-2 epimerization of aldohexoses. The reagent consisted of a Ni(II)-alkylenediamine derivative in methanol. The presence of ether linkages in the ligand increased the solubility of the complexes, and resulted in an increase in the rate of epimerization. Epimerization occured rapidly under mild conditions, and the same equilibrium point was reached regardless of whether the reaction was started from glucose or mannose. Among the ligands studied, N,N'-dialkylethyl-enediamine was the most active in C-2 epimerization.

  DOI：

  10.1016/0008-6215(91)80165-j

文献信息

• Polyaspartate derivatives for use in detergent compositions
  申请人：——

  公开号：US20030069153A1

  公开（公告）日：2003-04-10

  Polyaspartate derivatives, especially hydrophobically modified and/or hydrophilically modified polyaspartate derivatives, most especially polyaspartate derivatives that are both hydrophilically and hydrophobically modified, for use in detergent compositions, specifically laundry detergent compositions for providing cleaning, dispersancy, especially soil dispersion, builder properties and/or improved whitening of fabrics contacted by such detergent compositions; and methods for making such polyaspartate derivatives, and methods and articles employing such detergent compositions, are provided.

  本发明提供了聚天冬氨酸酯衍生物，特别是疏水改性和/或亲水改性聚天冬氨酸酯衍生物，尤其是既亲水又疏水改性的聚天冬氨酸酯衍生物，用于洗涤剂组合物，特别是洗衣粉组合物，为与此类洗涤剂组合物接触的织物提供清洁、分散性（尤其是土壤分散性）、增效特性和/或改进的增白效果；还提供了制造此类聚天冬氨酸酯衍生物的方法以及使用此类洗涤剂组合物的方法和物品。
• FR2274603
  申请人：——

  公开号：——

  公开（公告）日：——
• Structure–Activity Relationships in Toll-Like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides
  作者：Geetanjali Agnihotri、Breanna M. Crall、Tyler C. Lewis、Timothy P. Day、Rajalakshmi Balakrishna、Hemamali J. Warshakoon、Subbalakshmi S. Malladi、Sunil A. David

  DOI：10.1021/jm201071e

  日期：2011.12.8

  Toll-like receptor 2-agonistic lipopeptides typified by S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-R-cystein-yl-S-serine (PAM(2)CS) compounds are potential vaccine adjuvants. In continuation of previously reported structure activity relationships on this chemotype, we have determined that at least one acyl group of optimal length (C-16) and an appropriately oriented ester carbonyl group is essential for TLR2-agonistic activity. The spacing between one of the palmitoyl ester carbonyl and the thioether is crucial to allow for an important H-bond, which observed in the crystal structure of the lipopeptide:TLR2 complex; consequently, activity is lost in homologated compounds. Penicillamine-derived analogues are also inactive, likely due to unfavorable steric interactions with the carbonyl of Ser 12 in TLR2. The thioether in this chemotype can be replaced with a selenoether. Importantly, the thioglycerol motif can be dispensed with altogether and can be replaced with a thioethanol bridge. These results have led to a structurally simpler, synthetically more accessible, and water-soluble analogue possessing strong TLR2-agonistic activities in human blood,
• POLYASPARTATE DERIVATIVES FOR USE IN DETERGENT COMPOSITIONS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1417251A1

  公开（公告）日：2004-05-12
• NOVEL SELECTIVE INHIBITORS OF PROLYLCARBOXYPEPTIDASE
  申请人：Shariat-Madar Ziaeddin

  公开号：US20130310311A1

  公开（公告）日：2013-11-21

  The present invention relates to compounds of the formulae: in which C 5 -C 16 alkyl, R 1 is and isosteres and salts thereof.