3-(Acetyloxy)-12,13-epoxytrichothec-9-en-8-one, (3alpha)- | 109802-15-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-(Acetyloxy)-12,13-epoxytrichothec-9-en-8-one, (3alpha)-
• 英文别名: [(1R,2R,7R,9R,10R,12S)-1,2,5-trimethyl-4-oxospiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-10-yl] acetate
• CAS: 109802-15-5
• 化学式: C₁₇H₂₂O₅
• 分子量: 306.4
• InChiKey: LZIKLPMPLBZXHW-IKIFYQGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL MULTI-RING ORGANIC COMPOUNDS FOR REGULATING GUT MOTILITY AND FOOD INTAKE
  申请人：Enpharma L.P.

  公开号：EP1366052B1

  公开（公告）日：2006-03-22
• Novel multi-ring organic compounds for regulating gut motility and food intake
  申请人：——

  公开号：US20040102514A1

  公开（公告）日：2004-05-27

  Multi-ring organic compounds useful in compositions and methods for regulating gut motility to modulate food intake and treat obesity and malnutrition are described.
• [EN] NOVEL MULTI-RING ORGANIC COMPOUNDS FOR REGULATING GUT MOTILITY AND FOOD INTAKE<br/>[FR] NOUVEAUX COMPOSES ORGANIQUES A NOYAUX MULTIPLES POUR REGULER LE TRANSIT INTESTINAL ET EQUILIBRER LA RATION ALIMENTAIRE
  申请人：ENPHARMA L P

  公开号：WO2002055522A2

  公开（公告）日：2002-07-18

  Multi-ring organic compounds useful in compositions and methods for regulating gut motility to modulate food intake and treat obesity and malnutrition are described.
• [EN] A MULTI-RING REGULATOR OF GUT MOTILITY AND FOOD INTAKE<br/>[FR] REGULATEUR A ANNEAUX MULTIPLES DE TRANSIT INTESTINAL ET D'INGESTION D'ALIMENTS
  申请人：ENPHARMA L P

  公开号：WO2004009074A2

  公开（公告）日：2004-01-29

  Compositions and methods comprising 3α-acetoxy-12,13-epoxy-9-methyltrichothecen-9-en-7α,8α,15-triol are described for regulating gut motility to reduce food intake, to treat excessive weight gain, and to treat obesity.
• [EN] MULTI-RING COMPOUNDS FOR REGULATING GUT MOTILITY, FOOD INTAKE, AND WEIGHT GAIN<br/>[FR] COMPOSES POLYCYCLIQUES PERMETTANT DE REGULER LE TRANSIT INTESTINAL, LA PRISE D'ALIMENTS ET LA PRISE DE POIDS
  申请人：ENPHARMA L P

  公开号：WO2006006082A2

  公开（公告）日：2006-01-19

  Multi-ring organic compounds that regulate gut motor activity, signal satiety, and reduce food intake in an individual are described Such compounds are useful to regulate food consumption and to treat conditions of excessive weight gam and obesity. These compounds are trichothecanes or trichothecenes of Formula I: wherein x is a single or double bond and R1 and R2 are, independently, selected from the group consisting of a branched or unbranched C1 to C6 alkyl group, a branched or unbranched C3 to C6 alkenyl group, a cyclic saturated C3-C6 ring, a monounsaturated C4-C6 ring, an optionally substituted aryl group, and a 5 or 6-membered heteroaromatic ring