6-N-(3,3-dimethylallyl)adenosine | 7724-76-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-N-(3,3-dimethylallyl)adenosine
• 英文别名: (2R,3S,4R)-2-(hydroxymethyl)-5-[6-(3-methylbut-2-enylamino)purin-9-yl]oxolane-3,4-diol
• CAS: 7724-76-7；33156-15-9
• 化学式: C₁₅H₂₁N₅O₄
• 分子量: 335.363
• InChiKey: USVMJSALORZVDV-FJFSNTMWSA-N

物化性质

• 熔点：
  143-146°C
• 沸点：
  647.2±65.0 °C(Predicted)
• 密度：
  1.56±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO（少量）、甲醇（少量、超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  29400090
• RTECS号：
  AU7404910
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  6-N-(3,3-dimethylallyl)adenosine 在 叔丁基过氧化氢 、 selenium(IV) oxide 作用下， 以 二氯甲烷 、 苯 为溶剂， 以44%的产率得到6-((E)-4-hydroxy-3-methylbut-2-enylamino)-9-β-D-ribofuranosylpurine
  参考文献：
  名称：

  简便，廉价的途径可用于E和Z玉米赤素核糖苷及其衍生物，可用于免疫测定。

  摘要：

  6-N-（3,3-二甲基烯丙基）腺苷1的烯丙基氧化得到反式（E）玉米饼核糖苷3，其通过uv辐射异构化为顺式（Z）异构体5。给出了这些核苷的区域特异性3'-O-琥珀酰化的方法。

  DOI：

  10.1016/s0040-4039(00)86749-0

文献信息

• METHODS FOR CONTROLLING GIBBERELLIN LEVELS
  申请人：ARNOLD WHITE & DURKEE

  公开号：US20020053095A1

  公开（公告）日：2002-05-02

  Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase, 3-&bgr; hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing a RNA or protein product which suppresses the gibberellin biosynthetic pathway sequence, diverts substrates from the pathway or degrades pathway substrates or products. The sequence is preferably a copalyl diphosphate synthase sequence, a 3&bgr;-hydroxylase sequence, a 2-oxidase sequence, a phytoene synthase sequence, a C20-oxidase sequence, and a 2&bgr;,3&bgr;-hydroxylase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.

  本研究公开了抑制和控制赤霉素水平的方法和材料。特别是公开了 copalyl diphosphate synthase、3-&bgr; hydroxylase 和 2-oxidase 的核酸序列和其他核酸序列。赤霉素水平可以通过制备嵌合表达构建体来抑制或控制，该构建体能够表达抑制赤霉素生物合成途径序列、转移途径底物或降解途径底物或产物的 RNA 或蛋白质产物。该序列最好是共醛基二磷酸合成酶序列、3&bgr;-羟化酶序列、2-氧化酶序列、植物烯合成酶序列、C20-氧化酶序列和 2&bgr;,3&bgr;-羟化酶序列。施用补充剂，最好是赤霉素或赤霉素前体或中间体，可恢复生物活性。
• Methods for controlling gibberellin levels
  申请人：Monsanto Technology LLC.

  公开号：US20030233679A1

  公开（公告）日：2003-12-18

  Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase. 3-&bgr; hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing a RNA or protein product which suppresses the gibberellin biosynthetic pathway sequence, diverts substrates from the pathway or degrades pathway substrates or products. The sequence is preferably a copalyl diphosphate synthase sequence, a 3&bgr;-hydroxylase sequence, a 2-oxidase sequence, a phytoene synthase sequence, a C20-oxidase sequence, and a 2&bgr;,3&bgr;-hydroxylase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.

  本文公开了抑制和控制赤霉素水平的方法和材料。特别是公开了 copalyl diphosphate synthase.3-&bgr;羟化酶和 2-氧化酶的核酸序列以及其他核酸序列。赤霉素水平可以通过制备嵌合表达构建体来抑制或控制，该构建体能够表达抑制赤霉素生物合成途径序列、转移途径底物或降解途径底物或产物的 RNA 或蛋白质产物。该序列最好是共醛基二磷酸合成酶序列、3&bgr;-羟化酶序列、2-氧化酶序列、植物烯合成酶序列、C20-氧化酶序列和 2&bgr;,3&bgr;-羟化酶序列。施用补充剂，最好是赤霉素或赤霉素前体或中间体，可恢复生物活性。
• NUCLEIC ACID MOLECULES ENCODING CYTOCHROME P450-TYPE PROTEINS INVOLVED IN THE BRASSINOSTEROID SYNTHESIS IN PLANTS
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：EP0889963A1

  公开（公告）日：1999-01-13
• METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED
  申请人：Peyrottes Suzanne

  公开号：US20110118454A1

  公开（公告）日：2011-05-19

  The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.
• US5872104A
  申请人：——

  公开号：US5872104A

  公开（公告）日：1999-02-16