retinyl 4-phenylbutyrate | 880089-30-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: retinyl 4-phenylbutyrate
• 英文别名: [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] 4-phenylbutanoate
• CAS: 880089-30-5
• 化学式: C₃₀H₄₀O₂
• 分子量: 432.646
• InChiKey: NPJWEQGCRCHNNB-OQUUBLENSA-N

物化性质

• 沸点：
  556.7±29.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维生素 A 醋酸酯 、 4-苯基丁酸 在 Novozyme 435 (from Candida antarctica immobilized on acrylic resin) 作用下， 以 甲苯 为溶剂， 反应 21.0h， 生成 retinyl 4-phenylbutyrate
  参考文献：
  名称：

  Preparation of retinyl esters

  摘要：

  长链视黄醇酯是通过在酶的存在下，从短链视黄醇酯和适当的长链酸或酯经化酶过程制备而成的。使用各种添加剂可以增加所需酯的产量，并促进其纯化。

  公开号：

  US07566795B2

文献信息

• COMPOSITION COMPRISING AN HDAC INHIBITOR IN COMBINATION WITH A RETINOID
  申请人：DSM IP Assets B.V.

  公开号：EP1727516B1

  公开（公告）日：2014-05-14
• PREPARATION OF RETINYL ESTERS
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：EP2082056A2

  公开（公告）日：2009-07-29
• Composition Comprising an Hdac Inhibitor in Combination with a Retinoid
  申请人：Schehlmann Volker

  公开号：US20080227868A1

  公开（公告）日：2008-09-18

  The present invention is directed to compositions which contain a combination of at least one histone deacetylase inhibitor (HDAC inhibitor) and a retinoid. The composition is in particular a cosmetic preparation. It was found that the combination of an HDAC inhibitor and retinol or a derivative thereof is in particular useful for treating wrinkles but also for thickening the epidermis and for improving hair growth.
• Composition comprising an HDAC inhibitor in combination with a retinoid
  申请人：Schehlmann Volker

  公开号：US20100286278A1

  公开（公告）日：2010-11-11

  The present invention is directed to compositions which contain a combination of at least one histone deacetylase inhibitor (HDAC inhibitor) and a retinoid. The composition is in particular a cosmetic preparation. It was found that the combination of an HDAC inhibitor and retinol or a derivative thereof is in particular useful for treating wrinkles but also for thickening the epidermis and for improving hair growth.
• US7566795B2
  申请人：——

  公开号：US7566795B2

  公开（公告）日：2009-07-28