dimethyl 1'-(4-chlorophenyl)-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,2'-6,8-dihydroquinoline]-3',4'-dicarboxylate | 1374747-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: dimethyl 1'-(4-chlorophenyl)-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,2'-6,8-dihydroquinoline]-3',4'-dicarboxylate
• CAS: 1374747-60-0
• 化学式: C₂₈H₂₅ClN₂O₆
• 分子量: 520.969
• InChiKey: VOYIWJUHDOVSSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  靛红 、 对氯苯胺 、 5,5-二甲基-1,3-环己二酮 、 丁炔二酸二甲酯 以 溶剂黄146 为溶剂， 反应 24.0h， 以43%的产率得到dimethyl 1'-(4-chlorophenyl)-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,2'-6,8-dihydroquinoline]-3',4'-dicarboxylate
  参考文献：
  名称：

  四组分反应合成螺[indoline-3,2'-quinoline]衍生物

  摘要：

  成功开发了一种合成功能化四氢螺[indoline-3,2'-quinoline]衍生物的有效合成方法，该方法涉及芳胺、乙炔二甲酸二甲酯、靛红和环己烷-1,3-二酮在乙酸中的四组分反应酸。该反应的优点是原料通用，反应条件温和，操作简单。

  DOI：

  10.1002/ejoc.201101737

文献信息

• New Crown Ether-Based Nano Ionic Liquid ([DB-18-C-6K+][OH−] nIL): A Versatile Nanocatalyst for the Synthesis of Spiro[indoline-3,2′-quinoline] Derivatives via the Cascade Four-Component Reaction of Arylamines, Dialkylacetylenedicarboxylates, Isatins and Dimedone
  作者：Kobra Nikoofar、Shiva Khani

  DOI：10.1007/s10562-018-2391-7

  日期：2018.6

  UV–Vis spectroscopy techniques The obtained catalyst has been utilized for the one-pot, four-component synthesis of spiro[indoline-3,2′-quinoline] derivatives from the combination of isatins, amines, dimedone, and dialkylacetylenedicarboxylates. The advantages of this protocol included the use of common and easily-available starting materials, utilizing ambient temperature, non-toxic and inexpensive reagent

  以二苯并18-冠-6（[DB-18-C-6K+][OH-] nIL）为基础，通过简单的方法合成了一种新型纳米级冠醚基离子液体，并通过傅立叶变换表征红外光谱、核磁共振光谱、高分辨率扫描电子显微镜、能量色散 X 射线光谱、热重/差热分析和紫外-可见光谱技术所获得的催化剂已用于一锅四组分从靛红、胺、二甲酮和二烷基乙炔二羧酸盐的组合合成螺[indoline-3,2'-quinoline]衍生物。该协议的优点包括使用常见且易于获得的起始材料、利用环境温度、无毒且廉价的试剂使用、产品产量高、
• Heterogeneous bimetallic ZnFe2O4 nanopowder catalysed facile four component reaction for the synthesis of spiro[indoline-3,2′-quinoline] derivatives from isatins in water medium
  作者：Kamalesh Debnath、Animesh Pramanik

  DOI：10.1016/j.tetlet.2015.02.030

  日期：2015.3

  The bimetallic ZnFe2O4 nanopowder, a dual Lewis acid base combined catalyst is found to efficiently catalyse a four component reaction for the synthesis of functionalized tetrahydrospiro[indoline-3,2'-quinoline] derivatives from arylamines, dialkyl acetylenedicarboxylates, isatin derivatives and cyclohexane-1,3-diones in water medium at room temperature. Reduced reaction time, operational simplicity, elimination of hazardous solvent and more importantly, easy recoverability and reusability of the nanopowder make the present methodology economical, green and sustainable. (C) 2015 Elsevier Ltd. All rights reserved.
• Synthesis of Spiro[indoline-3,2′-quinoline] Derivatives through a Four-Component Reaction
  作者：Jing Sun、Yan Sun、Hong Gao、Chao-Guo Yan

  DOI：10.1002/ejoc.201101737

  日期：2012.4

  An efficient synthetic procedure for the synthesis of functionalized tetrahydrospiro[indoline-3,2′-quinoline] derivatives was successfully developed and involves the four-component reaction of arylamines, dimethyl acetylenedicarboxylate, isatins, and a cyclohexane-1,3-dione in acetic acid. The advantages of this reaction include the use of common starting materials and mild reaction conditions and

  成功开发了一种合成功能化四氢螺[indoline-3,2'-quinoline]衍生物的有效合成方法，该方法涉及芳胺、乙炔二甲酸二甲酯、靛红和环己烷-1,3-二酮在乙酸中的四组分反应酸。该反应的优点是原料通用，反应条件温和，操作简单。