epitheaflavic acid 3'-monogallate | 34218-97-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: epitheaflavic acid 3'-monogallate
• 英文别名: epitheaflavic acid-3-O-gallate；epitheaflavic acid 3-gallate；Epitheaflavinsaeure-3'-gallat；1-[(2R,3R)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-2-yl]-3,4,6-trihydroxy-5-oxobenzo[7]annulene-8-carboxylic acid
• CAS: 34218-97-8
• 化学式: C₂₈H₂₀O₁₄
• 分子量: 580.458
• InChiKey: RQTWDINIJYBFNS-QFQXNSOFSA-N

物化性质

• 沸点：
  1047.6±65.0 °C(Predicted)
• 密度：
  1.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  42
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  252
• 氢给体数：
  9
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  没食子酸 、 (-)-表儿茶素没食子酸酯 在 polyphenol oxidase 作用下， 反应 5.0h， 生成 epitheaflavic acid 3'-monogallate
  参考文献：
  名称：

  Benzotropolone derivatives and modulation of inflammatory response

  摘要：

  本发明提供了一种由通式表示的新型苯并三酮衍生物： 包括新茶黄素B和EGCGCa。本发明的苯并三酮衍生物是有效的抗氧化剂和抗炎药物。本发明还提供了一种高产率合成苯并三酮化合物的新方法，以及使用含有苯并三酮的化合物治疗炎症症状的方法。

  公开号：

  US20050049284A1

文献信息

• ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING
  申请人：SUNTORY HOLDINGS LIMITED

  公开号：US20150038573A1

  公开（公告）日：2015-02-05

  The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages. According to the present invention, a safe and palatable anti-obesity agent can be provided by incorporating a benzotropolone ring-containing compound which has tea-derived, high inhibitory activities against lipase and alfa-glucosidase. The anti-obesity agent of the present invention does not compromise the flavor of foods and beverage, has palatability, and can be used in various use applications including foods and beverages intended for health enhancement such as reduction in triglycerides.

  本发明的目的是提供一种含有茶叶成分的抗肥胖剂，该剂是安全的，不会影响食物和饮料的口味。根据本发明，通过加入一种含苯并环戊酮环的化合物，该化合物具有茶叶来源的高抑制脂肪酶和α-葡萄糖苷酶活性，可以提供一种安全和可口的抗肥胖剂。本发明的抗肥胖剂不会影响食物和饮料的口感，具有可口性，并可用于各种用途，包括旨在增强健康的食品和饮料，如减少甘油三酯含量。
• Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities
  作者：Shengmin Sang、Joshua D Lambert、Shiying Tian、Jungil Hong、Zhe Hou、Jae-He Ryu、Ruth E Stark、Robert T Rosen、Mou-Tuan Huang、Chung S Yang、Chi-Tang Ho

  DOI：10.1016/j.bmc.2003.10.024

  日期：2004.1

  Derivatives based on a benzotropolone skeleton (9-26) have been prepared by the enzymatic coupling (horseradish peroxidase/H2O2) of selected pairs of compounds (1-8), one with a vic-trihydroxyphenyl moiety, and the other with an ortho-dihydroxyphenyl structure. Some of these compounds have been found to inhibit TPA-induced mice ear edema, nitric oxide (NO) synthesis, and arachidonic acid release by LPS-stimulated RAW 264.7 cells. Their cytotoxic activites against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated. (C) 2003 Elsevier Ltd. All rights reserved.
• US8658237B2
  申请人：——

  公开号：US8658237B2

  公开（公告）日：2014-02-25
• US9169231B2
  申请人：——

  公开号：US9169231B2

  公开（公告）日：2015-10-27
• Benzotropolone derivatives and modulation of inflammatory response
  申请人：Ho Chi-Tang

  公开号：US20050049284A1

  公开（公告）日：2005-03-03

  The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.

  本发明提供了一种由通式表示的新型苯并三酮衍生物： 包括新茶黄素B和EGCGCa。本发明的苯并三酮衍生物是有效的抗氧化剂和抗炎药物。本发明还提供了一种高产率合成苯并三酮化合物的新方法，以及使用含有苯并三酮的化合物治疗炎症症状的方法。