2-oxopentanoyl chloride | 207223-17-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-oxopentanoyl chloride
• 英文别名: Pentanoyl chloride, 2-oxo-
• CAS: 207223-17-4
• 化学式: C₅H₇ClO₂
• 分子量: 134.562
• InChiKey: SYRMUFNMCMVUGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-oxopentanoyl chloride 在 盐酸 、 4-二甲氨基吡啶 、 钾硼氢 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 19.0h， 生成 (S)-2-hydroxymethyl-N-((R)-2-hydroxy)-pentanoyl pyrrolidine
  参考文献：
  名称：

  Asymmetric reactions of α-ketoacid-derived hemiacetals: Stereoselective synthesis of α-hydroxy acids

  摘要：

  N-Acylation of prolinol with alpha-ketoacid chlorides results in concomitant hemiacetalization of the alpha-keto amide by the prolinol hydroxyl group, (R) or (S) alpha-hydroxy acids are obtained with good enantiomeric excess by stereodivergent reduction of these hemiacetals. Reaction with Grignard reagents at ambient temperature furnishes (R) alpha-alkyl mandelic acids with good stereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00914-4
• 作为产物：
  描述：

  2-戊酮酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-oxopentanoyl chloride
  参考文献：
  名称：

  氮杂七元环的对映选择性有机催化合成的临时桥策略。

  摘要：

  我们报告了zezee部分的第一个对映选择性有机催化多米诺骨牌合成。这种临时桥策略基于概念上原始的环境亲电和1,4-双亲核α-酮酰胺与1,3-双亲电子烯醛的环化反应。可以将获得的氧桥联的氮杂环丙烷选择性地转化成具有高合成价值的光学活性的氮杂环庚烷，氮杂环丁烷或氮杂环丁烷衍生物。

  DOI：

  10.1039/c4cc07731h

文献信息

• [EN] PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS<br/>[FR] DERIVES DE PYRROLE SERVANT DE COMPOSES ANTI-MYCOBACTERIENS
  申请人：LUPIN LTD

  公开号：WO2004026828A1

  公开（公告）日：2004-04-01

  Novel pyrrole derivatives of formula (I), and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).

  公式(I)的新型吡咯衍生物及其药学上可接受的酸盐，在临床上对结核分枝杆菌的敏感和耐药菌株具有优越的抗结核活性，且与已知化合物相比具有较低的毒性。利用公式(I)的新型化合物治疗潜伏性结核病，包括多药耐药结核病（MDR TB）。制备新型化合物的方法，含有新型化合物的药物组合物以及通过给予公式(I)化合物治疗MDR TB的方法。
• N-[2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl]oxamides as light stabilisers
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0593936A1

  公开（公告）日：1994-04-27

  This invention relates to novel UV absorbers, their methods of preparation, their use in stabilizing polymers and polymers so stabilized against the degradative effects of UV light. The novel compounds of formula I are oxamides which are substituted on one or both nitrogens with a 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl group. The 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl groups are efficient UV absorbing groups and the oxamide group contributes additional light stabilizing, heat stabilizing and metal complexing properties to the compounds. The compounds have low-volatility and are especially useful as UV stabilizers for engineering resins processed at high temperatures.

  这项发明涉及新型紫外线吸收剂，其制备方法，其在稳定聚合物中的使用以及通过紫外线光的降解作用而得到稳定的聚合物。公式I的新型化合物是氧酰胺，其在一个或两个氮上被2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团取代。2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团是高效的紫外线吸收基团，而氧酰胺基团则为化合物提供了额外的光稳定、热稳定和金属络合性能。这些化合物具有低挥发性，特别适用于在高温下加工的工程树脂的紫外线稳定剂。
• Antimycobacterial pharmaceutical composition
  申请人：Arora Kumar Sudershan

  公开号：US20050256128A1

  公开（公告）日：2005-11-17

  An antimycobacterial combination and composition for treating tuberculosis are described. The compounds used are N-(3-[[4-(3-trifluoromethylphenyl)piperazinyl]methyl]-2-methyl-5-phenyl-pyrrolyl)-4-pyridylcarboxamide of formula (I) or a pharmaceutically acceptable non-toxic salt thereof and an amount of one or more first line antitubercular drugs.

  描述了一种用于治疗结核病的抗分枝杆菌联合组合物和组合物。所使用的化合物为式（I）的N-(3-[[4-(3-三氟甲基苯基)哌嗪基]甲基]-2-甲基-5-苯基-吡咯基)-4-吡啶基甲酰胺，或其药学上可接受的非毒性盐，以及一种或多种一线抗结核药物的数量。
• Pyrrole derivatives as antimycobacterial compounds
  申请人：Arora Kumar Sudershan

  公开号：US20050107370A1

  公开（公告）日：2005-05-19

  Novel pyrrole derivatives of formula (I) and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).

  式(I)的新型吡咯衍生物及其药学上可接受的酸盐，具有优异的抗结核杆菌活性，对临床敏感和耐药菌株的Mycobacterium tuberculosis均有效，并且与已知化合物相比具有较小的毒性。使用式(I)的新型化合物治疗潜伏性结核病，包括多重耐药结核病（MDR TB）。制备新型化合物的方法，含有新型化合物的制药组合物以及通过给予式(I)化合物治疗MDR TB的方法。
• Ink-jet recording material and ink for ink-jet recording
  申请人：——

  公开号：US20030072923A1

  公开（公告）日：2003-04-17

  There are disclosed an ink-jet recording material comprising a support, and an ink-receptive layer provided on the support, wherein the ink-jet recording material contains at least one compound selected from a carbohydrazide compound in which at least one nitrogen atom at 1-position and 5-position is substituted by two substituents other than a hydrogen atom and a compound having a 4-oxysemicarbazide structure, and ink for ink-jet recording comprising at least one of the above-mentioned compound.

  本发明揭示了一种喷墨记录材料，包括支撑体和设置在支撑体上的墨水吸收层，其中喷墨记录材料包含至少一种选择自1-位置和5-位置的至少一种氮原子被除氢原子和具有4-氧基半脲结构的两个取代基取代的碳酰肼化合物以及墨水，所述墨水包括上述化合物之一。