rhizoxin | 95917-95-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: rhizoxin
• 英文别名: (1S,3R,5R,8S,10S,11S,13R,14E,16R,17R)-10-hydroxy-8-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]henicos-14-ene-6,19-dione
• CAS: 95917-95-6；90996-54-6
• 化学式: C₃₅H₄₇NO₉
• 分子量: 625.759
• InChiKey: OWPCHSCAPHNHAV-OIQHSNMRSA-N

物化性质

• 熔点：
  131-135°
• 比旋光度：
  D24 +155.5° (c = 0.8 in methanol)
• 沸点：
  664.44°C (rough estimate)
• 密度：
  1.1777 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  45
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  133
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  rhizoxin 生成 (1S,3R,5R,8S,10S,11S,13R,14E,16R,17R)-10-hydroxy-8-[(2S,3R,4E,6E,8Z)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]henicos-14-ene-6,19-dione
  参考文献：
  名称：

  KATO, YUZO;OGAWA, YUJI;IMADA, TAKASHI;IWASAKI, SHIGEO;SHIMAZAKI, NAOMI;KO+, J. ANTIBIOTICS, 44,(1991) N, C. 66-75

  摘要：

  DOI：

文献信息

• ERYTHROPOIETIN: REMODELING AND GLYCOCONJUGATION OF ERYTHROPOIETIN
  申请人：DeFrees Shawn

  公开号：US20070042458A1

  公开（公告）日：2007-02-22

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
  申请人：DeFrees Shawn

  公开号：US20080050772A1

  公开（公告）日：2008-02-28

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Factor VIII: Remodeling and glycoconjugation of factor VIII
  申请人：DeFrees Shawn

  公开号：US20080070275A1

  公开（公告）日：2008-03-20

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Erythropoietin: remodeling and glycoconjugation of erythropoietin
  申请人：DeFrees Shawn

  公开号：US20080187955A1

  公开（公告）日：2008-08-07

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• GLUCOSAMINE NUCLEOTIDE SUGARS
  申请人：DeFrees Shawn

  公开号：US20090137763A1

  公开（公告）日：2009-05-28

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.