N-[(4aR,6S,7R,8R,8aS)-8-hydroxy-6-octoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]acetamide | 215302-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: N-[(4aR,6S,7R,8R,8aS)-8-hydroxy-6-octoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]acetamide
• CAS: 215302-00-4
• 化学式: C₂₃H₃₅NO₆
• 分子量: 421.534
• InChiKey: LPGRRPHIQMHCMP-UWPRFDSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[(4aR,6S,7R,8R,8aS)-8-hydroxy-6-octoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]acetamide 在 4 A molecular sieve 、 camphor-10-sulfonic acid 、 四丁基溴化铵 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.5h， 生成 Bn(-2)[Bn(-3)][Bn(-4)]Fuc(a1-3)GlcNAc(a)-O-octyl
  参考文献：
  名称：

  Novel Disaccharide Inhibitors of Human Glioma Cell Division

  摘要：

  Several alpha-L-Fuc-(1-->3)-alpha-D-GlcNAcOC(8)H(17) disaccharide derivatives bearing different hydroxylated alkyl chains, with or without sulfate groups at C-4 and/or C-6 positions of the GlcNAc unit, have been synthesized and-tested as inhibitors of human astrocytoma Lines U-373 and U-118. The antimitotic activity was dependent on the structure and position of the hydroxylated chain linked to the disaccharide. The compounds with a pentaerythritol or L-glyceryl chain at the C-6 position showed the best inhibitory properties, with an ID50 value of ca. 200 mu M. On the contrary, sulfated disaccharide derivatives were inactive. The antimitotic activities of the compounds tested were essentially independent of the mitogen used to stimulate cell division.

  DOI：

  10.1021/jm980365i
• 作为产物：
  描述：

  D-GlcNAc 在 三氟化硼乙醚 、 对甲苯磺酸 作用下， 以 乙腈 为溶剂， 反应 21.0h， 生成 N-[(4aR,6S,7R,8R,8aS)-8-hydroxy-6-octoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl]acetamide
  参考文献：
  名称：

  Novel Disaccharide Inhibitors of Human Glioma Cell Division

  摘要：

  Several alpha-L-Fuc-(1-->3)-alpha-D-GlcNAcOC(8)H(17) disaccharide derivatives bearing different hydroxylated alkyl chains, with or without sulfate groups at C-4 and/or C-6 positions of the GlcNAc unit, have been synthesized and-tested as inhibitors of human astrocytoma Lines U-373 and U-118. The antimitotic activity was dependent on the structure and position of the hydroxylated chain linked to the disaccharide. The compounds with a pentaerythritol or L-glyceryl chain at the C-6 position showed the best inhibitory properties, with an ID50 value of ca. 200 mu M. On the contrary, sulfated disaccharide derivatives were inactive. The antimitotic activities of the compounds tested were essentially independent of the mitogen used to stimulate cell division.

  DOI：

  10.1021/jm980365i

文献信息

• Novel Disaccharide Inhibitors of Human Glioma Cell Division
  作者：Begoña Aguilera、Lorenzo Romero-Ramírez、José Abad-Rodríguez、Guillermo Corrales、Manuel Nieto-Sampedro、Alfonso Fernández-Mayoralas

  DOI：10.1021/jm980365i

  日期：1998.11.1

  Several alpha-L-Fuc-(1-->3)-alpha-D-GlcNAcOC(8)H(17) disaccharide derivatives bearing different hydroxylated alkyl chains, with or without sulfate groups at C-4 and/or C-6 positions of the GlcNAc unit, have been synthesized and-tested as inhibitors of human astrocytoma Lines U-373 and U-118. The antimitotic activity was dependent on the structure and position of the hydroxylated chain linked to the disaccharide. The compounds with a pentaerythritol or L-glyceryl chain at the C-6 position showed the best inhibitory properties, with an ID50 value of ca. 200 mu M. On the contrary, sulfated disaccharide derivatives were inactive. The antimitotic activities of the compounds tested were essentially independent of the mitogen used to stimulate cell division.