Abstract We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid
摘要我们设计并合成了杂合子6,该杂合子由小沟黏合剂迪斯坦霉素A和
吡咯并[2,1-c] [1,4]苯并二氮杂P(
PBD)4组成,涉及天然
蒽醌(2)和DC-81。 (3)。本文研究了化合物6对DNA与转录因子Sp1之间分子相互作用的影响。获得的结果表明,
PBD-
地霉素的杂种是Sp1 / DNA相互作用的有力
抑制剂。