carpipramine dihydrochloride | 7075-03-8

• 物质功能分类: 原料药 - 神经系统用药 - 抗抑郁、躁狂药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: carpipramine dihydrochloride
• 英文别名: 1-[3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide;hydrochloride
• CAS: 7075-03-8
• 化学式: C₂₈H₃₈N₄O*2ClH
• 分子量: 519.558
• InChiKey: HWYYJNSVQYLSCT-UHFFFAOYSA-N

物化性质

• 熔点：
  260°
• 溶解度：
  DMSO（少许）、甲醇（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.54
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  52.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 储存条件：
  库房应保持低温、通风和干燥。

制备方法与用途

用途

盐酸卡匹帕明是一种非典型抗精神病药，用于治疗精神分裂症和焦虑症。它在结构上与丙咪嗪（I465980）相似。

分类

有毒物质

毒性分级

中毒

急性毒性

• 口服 - 大鼠 LD50: 1,025 毫克/公斤
• 口服 - 小鼠 LD50: 2,180 毫克/公斤

燃烧危险特性

热分解时排出有毒氮氧化物烟雾

储运特性

库房低温、通风干燥保存

灭火剂

水、二氧化碳、泡沫、干粉

文献信息

• Medicated plasters
  申请人：NITTO DENKO CORPORATION

  公开号：EP0387751A2

  公开（公告）日：1990-09-19

  Medicated plasters composed of a flexible support and a pressure-sensitive adhesive layer laminated thereon, in which said pressure-sensitive adhesive layer has an exposed surface with pH of 7 or higher and contains one of the following three components: (i) a basic physiologically active agent and an acidic substance, (ii) a salt of a basic physiologically active agent and a basic substance, and (iii) a basic physiolosically active agent and a salt of a basic physiolosically active agent.

  药用膏药，由柔性支架和层压在其上的压敏胶层组成，其中所述压敏胶层的外露表面 pH 值为 7 或更高，并含有以下三种成分之一： (i) 碱性生理活性剂和酸性物质、 (ii) 碱性生理活性剂和碱性物质的盐，以及 (iii) 碱性生理活性剂和碱性生理活性剂的盐。
• NOVEL AMINES AND THEIR USE
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0424525A1

  公开（公告）日：1991-05-02

  Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

  本发明公开了通式（1）代表的胺及其酸加成盐和季铵盐。由式（1）代表的胺或其药学上可接受的酸加成盐和季铵盐可用于治疗和预防动物的心脏疾病，特别是心律失常、心肌梗塞、心绞痛、心力衰竭等。
• Adhesive device for transdermal administration of an active agent
  申请人：NITTO DENKO CORPORATION

  公开号：EP0452837A2

  公开（公告）日：1991-10-23

  A medical adhesive comprising a plaster layer containing the following ingredients, characterized in that the ingredient ② is incorporated in a larger amount than the ingredient ⑤ and in an amount not less than 25% by weight relative to the total amount of the ingredients ①∼⑤, and the plaster layer is a W/O type : ① a medicinal ingredient, ② a hydrophobic polymer having a glass transition temperature (Tg) of -65°C to 35°C, ③ a percutaneous absorption-promoting agent, ④ water, and ⑤ a hydrophilic polymer which is soluble or capable of swelling in water; and a medical adhesive which comprises a porous base layer in the plaster layer or in contact with the plaster layer, which enable stable release of the medicinal ingredient, the percutaneous absorption-promoting agents and so on and sustaining of the pharmacological effects over a long period.

  一种医用粘合剂，由含有下列成分的石膏层组成，其特征在于，成分②的掺入量大于成分⑤，且相对于成分①∼⑤的总掺入量不低于 25%（重量百分比），石膏层为 W/O 型： 药物成分、 一种疏水性聚合物，其玻璃转化温度（Tg）为-65°C 至 35°C、 经皮吸收促进剂、 水，以及 可溶于水或能在水中溶胀的亲水性聚合物；以及 一种医用粘合剂，由石膏层中的多孔基底层或与石膏层接触的多孔基底层组成，可使药物成分、促进经皮吸收剂等稳定释放，并长期保持药理作用。
• SUSTAINED-RELEASE MICROSPHERE CONTAINING ANTIPSYCHOTIC AND PROCESS FOR PRODUCING THE SAME
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0669128A1

  公开（公告）日：1995-08-30

  A sustained-release microsphere produced by enclosing a hydrophobic antipsychotic such as bromperidol or haloperidol in a base comprising a biocompatible polymer such as polylactic acid or a lactic acid/glycolic acid copolymer. It can exhibit a desired pharmacological effect, where a long-term administration is necessary, by injecting once every 1 to 8 weeks instead of every day. As a result, a remarkable improvement can be expected in the compliance during maintenance therapy. In addition, the use of the biocompatible polymer serves to entirely dispense with surgical operations such as implantation, facilitates hypodermic and intramuscular injection just like the case of suspending injection, and can dispense with the widrawal of the microsphere. Furthermore, the microsphere can be administered with little aversion and pain.

  一种缓释微球，将溴哌利多或氟哌啶醇等疏水性抗精神病药物包裹在由聚乳酸或乳酸/乙醇酸共聚物等生物相容性聚合物组成的基质中。在需要长期用药的情况下，只需每 1 至 8 周注射一次，而不是每天注射一次，就能发挥理想的药理作用。因此，可望显著改善维持治疗期间的依从性。此外，使用生物相容性聚合物可以完全省去植入等外科手术，方便皮下注射和肌肉注射，就像悬浮注射一样，还可以省去微球的拉伸。此外，施用微球时几乎不会产生厌恶感和疼痛感。
• Pharmaceutical preparations based on active ingredients susceptible to illict administration
  申请人：ALTERGON S.A.

  公开号：EP1273301A2

  公开（公告）日：2003-01-08

  The present invention provides oral pharmaceutical preparations unsuitable for illicit administration to victims.

  本发明提供了不适合非法给受害者服用的口服药物制剂。