8-acetyl-3-benzyloxy-2-methoxybenzo[c]chromen-6-one | 524713-47-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8-acetyl-3-benzyloxy-2-methoxybenzo[c]chromen-6-one
• 英文别名: 8-Acetyl-2-methoxy-3-phenylmethoxybenzo[c]chromen-6-one
• CAS: 524713-47-1
• 化学式: C₂₃H₁₈O₅
• 分子量: 374.393
• InChiKey: OCVSGVQGDCYSFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-acetyl-3-benzyloxy-2-methoxybenzo[c]chromen-6-one 在 palladium 10% on activated carbon 甲酸 、 sodium formate 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 丙酮 为溶剂， 反应 7.0h， 以80%的产率得到8-Acetyl-3-hydroxy-2-methoxybenzo[c]chromen-6-one
  参考文献：
  名称：

  Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis

  摘要：

  本文描述了一种预防和/或治疗皮肤疾病的组合物和方法，包括但不限于银屑病和特应性皮炎，以及提供抗衰老益处，减少皱纹和老化皮肤的出现，改善皮肤颜色，治疗光损伤皮肤，改善皮肤的光泽和清晰度以及完美度，以及使皮肤呈现整体健康和年轻外观，涉及使用一个或多个苯并[c]色素-6-酮衍生物的异常血管生成和增生。

  公开号：

  US20060257337A1
• 作为产物：
  描述：

  2-溴-5-羟基-4-甲氧基苯甲醛 在 sodium hydroxide 、 四(三苯基膦)钯 、 正丁基锂 、 氯化亚砜 、 sodium hydride 、 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 104.66h， 生成 8-acetyl-3-benzyloxy-2-methoxybenzo[c]chromen-6-one
  参考文献：
  名称：

  Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor

  摘要：

  The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific inhibitors of endothelial cell proliferation.

  DOI：

  10.1021/jm034007d

文献信息

• COMPOSITIONS AND METHODS TO TREAT DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS
  申请人：Sherris I. David

  公开号：US20070197567A1

  公开（公告）日：2007-08-23

  Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了使用一种或多种苯并[c]色酮-6-酮衍生物预防和/或治疗涉及异常血管生成的疾病的组合物和方法。
• COMPOSITIONS AND METHODS TO TREAT SKIN DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS
  申请人：SHERRIS David

  公开号：US20110268679A1

  公开（公告）日：2011-11-03

  Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photodamaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin, involving aberrant angiogenesis and hyperplasia employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了一种预防和/或治疗皮肤疾病的组合物和方法，包括但不限于银屑病和特应性皮炎，以及提供抗衰老效益，从而减少皱纹和老化皮肤的出现，改善皮肤颜色，治疗光损伤皮肤，改善皮肤的光泽度和清晰度，以及整体健康和年轻的外观，涉及异常血管生成和增生，并采用一种或多种苯并[c]色酮衍生物。
• COMPOSITIONS AND METHODS TO TREAT DISEASE CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS
  申请人：Paloma Pharmaceuticals, Inc.

  公开号：US20140105920A1

  公开（公告）日：2014-04-17

  Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了使用一种或多种苯并[c]色酮-6-酮衍生物预防和/或治疗涉及异常血管生成的疾病的组合物和方法。
• Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
  申请人：Paloma Pharmaceuticals, Inc.

  公开号：EP2543371A1

  公开（公告）日：2013-01-09

  Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.

  本文描述了使用一种或多种苯并[c]色烯-6-酮衍生物预防和/或治疗涉及异常血管生成的疾病的组合物和方法。
• Compounds, compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
  申请人：Paloma Pharmaceuticals, Inc.

  公开号：EP2517702A1

  公开（公告）日：2012-10-31

  Described herein are compounds, compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photodamaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin, involving aberrant angiogenesis and hyperplasia employing one for more benzo[c]chromen-6-one derivatives.

  本文描述的化合物、组合物和方法用于预防和/或治疗皮肤疾病，包括但不限于银屑病和特应性皮炎，以及提供抗衰老益处，从而减少皱纹和老化皮肤的出现，改善皮肤颜色，治疗光损伤皮肤，改善皮肤的光泽度、透明度和光洁度，以及皮肤的整体健康和年轻外观，涉及使用一种或多种苯并[c]色烯-6-酮衍生物的异常血管生成和增生。