6-Sulfanylquinoline-2(1H)-thione | 110131-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Sulfanylquinoline-2(1H)-thione
• 英文别名: 6-sulfanyl-1H-quinoline-2-thione
• CAS: 110131-14-1
• 化学式: C₉H₇NS₂
• 分子量: 193.293
• InChiKey: YQHVPYSLTJVQIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Sulfanylquinoline-2(1H)-thione 在 盐酸 、 sodium hypochlorite 作用下， 以 氯仿 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-氯喹啉-6-磺酰氯
  参考文献：
  名称：

  From 2,3-, 2,6-, 3,4- and 4,6-Dichloroquinolines to Isomeric Chloroquinolinesulfonyl Chlorides

  摘要：

  The action of sodium methanethiolate (in boiling DMF) on x,y-dichloroquinolines (1) (x=3 or 6, y=2 or 4) occured via chlorine ipso-substitution followed by methanethiolato-S-demthylation to yield x,y-quinolinedithiolates 2A which were: i) subjected to S-methylation, ii) oxidatively chlorinated to y,y'-bis(x-chloro-x-quinolinesulfonyl chlorides (5). Oxidative chlorination of y,y'-bis(x-chloro quinolinyl) disulfides (7) led to x-chloro-y-quinolinesulfonyl chlorides (8) accompanied by x,y-dichloroquinolines (1). Both quinolinessulfonyl chlorides 5 and 8 were efficiently converted to the corresponding quinolinesulfonamides 6 and 9.

  DOI：

  10.3987/com-09-11855
• 作为产物：
  描述：

  2,6-二氯喹啉 、 sodium thiomethoxide 在 盐酸 作用下， 以 N,N-二甲基甲酰胺 、 水 为溶剂， 反应 4.0h， 生成 二甲基硫 、 6-Sulfanylquinoline-2(1H)-thione
  参考文献：
  名称：

  From 2,3-, 2,6-, 3,4- and 4,6-Dichloroquinolines to Isomeric Chloroquinolinesulfonyl Chlorides

  摘要：

  The action of sodium methanethiolate (in boiling DMF) on x,y-dichloroquinolines (1) (x=3 or 6, y=2 or 4) occured via chlorine ipso-substitution followed by methanethiolato-S-demthylation to yield x,y-quinolinedithiolates 2A which were: i) subjected to S-methylation, ii) oxidatively chlorinated to y,y'-bis(x-chloro-x-quinolinesulfonyl chlorides (5). Oxidative chlorination of y,y'-bis(x-chloro quinolinyl) disulfides (7) led to x-chloro-y-quinolinesulfonyl chlorides (8) accompanied by x,y-dichloroquinolines (1). Both quinolinessulfonyl chlorides 5 and 8 were efficiently converted to the corresponding quinolinesulfonamides 6 and 9.

  DOI：

  10.3987/com-09-11855

文献信息

• METAL TRIANGULO COMPOUND AND METHODS OF USING THE SAME
  申请人：National University of Singapore

  公开号：EP2147005A1

  公开（公告）日：2010-01-27
• US8399447B2
  申请人：——

  公开号：US8399447B2

  公开（公告）日：2013-03-19
• [EN] METAL TRIANGULO COMPOUND AND METHODS OF USING THE SAME<br/>[FR] COMPOSÉ TRIANGULO DE MÉTAL ET PROCÉDÉ D'UTILISATION DE CELUI-CI
  申请人：UNIV SINGAPORE

  公开号：WO2008127197A1

  公开（公告）日：2008-10-23

  [EN] The present invention relates to a metal triangulo compound. Provided is also a method of inducing apoptosis in a cell that comprises administering the metal triangulo compound. Provided is also a method of preventing carcinogenesis in a cell that comprises administering the metal triangulo compound.
  [FR] La présente invention concerne un composé triangulo de métal. L'invention concerne également un procédé d'induction de l'apoptose dans une cellule qui comprend l'administration du composé triangulo de métal. L'invention concerne également un procédé de prévention de la carcinogenèse dans une cellule, comprenant l'administration du composé triangulo de métal.
• From 2,3-, 2,6-, 3,4- and 4,6-Dichloroquinolines to Isomeric Chloroquinolinesulfonyl Chlorides
  作者：Krzysztof Marciniec、Andrzej Maślankiewicz

  DOI：10.3987/com-09-11855

  日期：——

  The action of sodium methanethiolate (in boiling DMF) on x,y-dichloroquinolines (1) (x=3 or 6, y=2 or 4) occured via chlorine ipso-substitution followed by methanethiolato-S-demthylation to yield x,y-quinolinedithiolates 2A which were: i) subjected to S-methylation, ii) oxidatively chlorinated to y,y'-bis(x-chloro-x-quinolinesulfonyl chlorides (5). Oxidative chlorination of y,y'-bis(x-chloro quinolinyl) disulfides (7) led to x-chloro-y-quinolinesulfonyl chlorides (8) accompanied by x,y-dichloroquinolines (1). Both quinolinessulfonyl chlorides 5 and 8 were efficiently converted to the corresponding quinolinesulfonamides 6 and 9.