2-[2-[2-[2-(4-Methylphenyl)sulfonylethoxy]ethoxy]ethoxy]ethanol | 145523-37-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[2-[2-[2-(4-Methylphenyl)sulfonylethoxy]ethoxy]ethoxy]ethanol
• 英文别名: 2-[2-[2-[2-(4-methylphenyl)sulfonylethoxy]ethoxy]ethoxy]ethanol
• CAS: 145523-37-1
• 化学式: C₁₅H₂₄O₆S
• 分子量: 332.418
• InChiKey: MTXUKCPHYIWOKU-UHFFFAOYSA-N

物化性质

• 沸点：
  512.9±50.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[2-[2-[2-(4-Methylphenyl)sulfonylethoxy]ethoxy]ethoxy]ethanol 、 4-N-苯基苯酰胺 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 48.0h， 以92%的产率得到4′-tetra(ethylene glycol)-azobenzene
  参考文献：
  名称：

  Conformation of Novel Azo-Dyes Bearing End-Capped Oligo(ethylene glycol) Studied by UV–vis and NMR Spectroscopy

  摘要：

  Two novel azo-dyes bearing an end-capped oligo(ethylene glycol) chain were synthesized and then studied by UV-visible and NMR. spectroscopy. For both azobenzenes, the end-capped oligo(ethylene glycol) segment is on the para position of the first phenyl ring. On the second phenyl ring, a methoxy group is added on the para position for one azodye and no substitution group on the other, which made them electronically a push push and a push system, respectively. The presence of the methoxy group changes significantly the absorption and the photoisomerization behaviors and results in a much less intense absorbance for the trans isomer and a shift from 350 to 360 nm. In the kinetic studies the azobenzene bearing a methoxy group shows a zero-order and a first-order kinetics as a function of the time scale of the study as well as an aggregation phenomenon. This azo-dye in different solvents has been studied by H-1 NMR and pulsed gradient NMR experiments to understand the effects of the photoisomerization and the aggregation on the self-diffusion of these molecules in solutions.

  DOI：

  10.1021/acs.jpcb.5b05853
• 作为产物：
  描述：

  三缩四乙二醇 、 对甲苯磺酰氯 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以31%的产率得到2-[2-[2-[2-(4-Methylphenyl)sulfonylethoxy]ethoxy]ethoxy]ethanol
  参考文献：
  名称：

  PHOTOREACTIVE MONOMERS

  摘要：

  具有以下特性的光敏单体：(i) 至少一个自由基可聚合的C—C双键，(ii) 至少一个亲水基团，所述亲水基团被选自具有至少2个乙二醇基团的乙二醇基团和聚乙二醇基团，(iii) 至少一个光敏基团，所述光敏基团为光亚烯酮基团。同时提供一种制备该光敏单体的方法。

  公开号：

  US20140073810A1

文献信息

• SYNTHESIS OF OBTAINING MODIFIED POLYETHYLENE GLYCOL INTERMEDIATES
  申请人：Engell Torgrim

  公开号：US20120004423A1

  公开（公告）日：2012-01-05

  The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.

  本发明提供了一种新颖且更高效的合成方法，用于获得在合成保护基氨氧基PEG连接剂中获得中间体。
• SYNTHESIS OF A PEG-6 MOIETY FROM COMMERCIAL LOW-COST CHEMICALS
  申请人：Engell Torgrim

  公开号：US20100324264A1

  公开（公告）日：2010-12-23

  The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

  本发明提供了一种新颖的合成方法，从经济实惠且易得的起始材料和化学品或改性聚乙二醇中获得保护基氨氧基PEG-6连接剂。更具体地说，通过一种新颖的合成方法，成功获得了一种改性的Boc保护的氨氧基PEG-6连接剂，使得该连接剂可以附着到向量上，例如基于肽的片段。
• Synthesis of a PEG-6 moiety from commercial low-cost chemicals
  申请人：GE Healthcare Limited

  公开号：EP2268609B1

  公开（公告）日：2013-01-30
• US8415510B2
  申请人：——

  公开号：US8415510B2

  公开（公告）日：2013-04-09
• US8536375B2
  申请人：——

  公开号：US8536375B2

  公开（公告）日：2013-09-17