1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-methoxybenzene | 849354-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-methoxybenzene
• CAS: 849354-61-6
• 化学式: C₁₈H₁₃F₁₇O
• 分子量: 568.273
• InChiKey: SQLQUOZNXPSOLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-methoxybenzene 在 四(三苯基膦)钯 三溴化硼-二甲基硫醚 三溴甲基硫化硼 、 溴 、 sodium hydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 二氯甲烷 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 126.0h， 生成 4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1-isopropoxy-2-vinylbenzene
  参考文献：
  名称：

  Synthesis, Reaction, and Recycle of Light Fluorous Grubbs−Hoveyda Catalysts for Alkene Metathesis

  摘要：

  Light fluorous versions of first- and second-generation Grubbs-Hoveyda metathesis catalysts are introduced. These exhibit the expected reactivity profile, are readily recovered from reaction mixtures by fluorous solid-phase extraction, and can be routinely reused five or more times. The catalysts can be used in a stand alone fashion, or supported on fluorous silica gel.

  DOI：

  10.1021/jo048001n
• 作为产物：
  描述：

  全氟辛基碘烷 在 四(三苯基膦)钯 偶氮二异丁腈 、 三甲基铝 、 三正丁基氢锡 作用下， 以 正己烷 、 二氯甲烷 、 苯 为溶剂， 反应 36.0h， 生成 1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-4-methoxybenzene
  参考文献：
  名称：

  Synthesis, Reaction, and Recycle of Light Fluorous Grubbs−Hoveyda Catalysts for Alkene Metathesis

  摘要：

  Light fluorous versions of first- and second-generation Grubbs-Hoveyda metathesis catalysts are introduced. These exhibit the expected reactivity profile, are readily recovered from reaction mixtures by fluorous solid-phase extraction, and can be routinely reused five or more times. The catalysts can be used in a stand alone fashion, or supported on fluorous silica gel.

  DOI：

  10.1021/jo048001n

文献信息

• Synthesis and Application of a Fluorous Lawesson's Reagent:  Convenient Chromatography-Free Product Purification
  作者：Zoltán Kaleta、Gábor Tárkányi、Ágnes Gömöry、Ferenc Kálmán、Tamás Nagy、Tibor Soós

  DOI：10.1021/ol0529849

  日期：2006.3.1

  [reaction: see text] A fluorous analogue of Lawesson's reagent for thionation of carbonyl compounds has been developed and its use demonstrated on a series of amides, esters, and ketones. The separation of the Lawesson's reagent-derived byproducts can be achieved by a simple fluorous solid-phase extraction.

  [反应：见正文]已经开发了Lawesson试剂的羰基化合物硫磺化反应的氟类似物，并在一系列酰胺，酯和酮上证明了其用途。可以通过简单的氟固相萃取来分离Lawesson试剂衍生的副产物。
• Synthesis, Reaction, and Recycle of Light Fluorous Grubbs−Hoveyda Catalysts for Alkene Metathesis
  作者：Masato Matsugi、Dennis P. Curran

  DOI：10.1021/jo048001n

  日期：2005.3.1

  Light fluorous versions of first- and second-generation Grubbs-Hoveyda metathesis catalysts are introduced. These exhibit the expected reactivity profile, are readily recovered from reaction mixtures by fluorous solid-phase extraction, and can be routinely reused five or more times. The catalysts can be used in a stand alone fashion, or supported on fluorous silica gel.