10-bromoundecanoic acid | 18294-93-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-bromoundecanoic acid
• 英文别名: 10-bromo-undecanoic acid；10-Brom-undecansaeure；10-Brom-undecylsaeure
• CAS: 18294-93-4
• 化学式: C₁₁H₂₁BrO₂
• 分子量: 265.191
• InChiKey: GRTAZJUBVKWZPH-UHFFFAOYSA-N

物化性质

• 熔点：
  35.5 °C
• 沸点：
  347.6±15.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-bromoundecanoic acid 在 丙酮 、 sodium iodide 作用下， 生成 10-iodo-undecanoic acid
  参考文献：
  名称：

  354.将氯化氢和碘化物加到烯烃中。十一碳烯酸

  摘要：

  DOI：

  10.1039/jr9360001605
• 作为产物：
  描述：

  2-十一烯酸 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 生成 10-bromoundecanoic acid
  参考文献：
  名称：

  碲化氢钠对烯烃的作用

  摘要：

  研究了碲化氢钠NaTeH对非亲电子碳-碳双键的作用，发现该反应对烯键上的取代基非常敏感。苯基共轭烯烃被还原为烷基苯，该试剂加成分离的单键和双取代的双键，从而生成有机碲衍生物，而与宝石双取代的键结合，则生成还原和加成产物的混合物。这些结果解释在涉及从碲化氢，HTE氢原子转移自由基对机制方面-双键。

  DOI：

  10.1016/s0040-4020(01)87834-0

文献信息

• Compositions of iodophenoxy alkanes and iodophenyl ethers in combination
  申请人：Sterling Winthrop Inc.

  公开号：US05607660A1

  公开（公告）日：1997-03-04

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodophenoxy alkane, iodophenyl alkenylalkyl ether or an iodophenyl alkynylalkyl ether x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

  本发明涉及一种口服或逆行检查胃肠道的X射线造影剂组合物，包括碘苯氧基烷，碘苯基烯基烷基醚或碘苯基炔基烷基醚X射线造影剂，与纤维素衍生物在药学上可接受的载体中组合；以及它们在胃肠道诊断放射学中使用的方法。
• Inhibition of selectin binding
  申请人：——

  公开号：US20010046970A1

  公开（公告）日：2001-11-29

  This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10 6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.

  本发明提供了一种抑制表达P-或L-选择素的细胞与表达相应配体的另一种细胞之间结合的组合物。制备了一种共价交联的脂质组合物，其中糖类和酸性基团分别存在于不同的脂质中。然后将该组合物插入细胞之间以抑制结合。在有效寡糖浓度下，抑制可以达到低于游离寡糖的106倍。由于选择素参与将细胞招募到损伤部位，因此这些组合物可以用于缓解某些炎症和免疫疾病。
• Compositions of iodophenoxy alkanes and iodophenyl ethers for
  申请人：Sterling Winthrop Inc.

  公开号：US05620677A1

  公开（公告）日：1997-04-15

  Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

  本发明涉及一种公式为##STR1##的对比剂，其包含在水性组合物中，并且用于诊断放射学中的胃肠道的方法，其中Z=H，卤素，C.sub.1-C.sub.20烷基，环烷基，较低的烷氧基，氰基，其中烷基和环烷基可以被卤素或卤素较低烷基置换；R=C.sub.1-C.sub.25烷基，环烷基或卤素较低烷基，可选择地被卤素，氟较低烷基，芳基，较低烷氧基，羟基，羧基，较低烷氧基羰基或较低烷氧基羰基氧基置换，(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q，或(CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1，R.sub.2，R.sub.3和R.sub.4独立地是较低烷基，可选择地被卤素置换；x为1-4；n为1-5；m为1-15；p为1-10；Q为H，较低烷基，较低烯基，较低炔基，较低烷基烯，芳基或芳基较低烷基。
• Compositions of iodophenoxy alkanes and iodophenyl ethers and
  申请人：Sterling Winthrop Inc.

  公开号：US05531979A1

  公开（公告）日：1996-07-02

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

  本发明涉及用于口服或逆行检查胃肠道的X射线造影剂组合物，包括碘苯氧烷烃和碘苯醚作为X射线产生剂，与药学上可接受的黏土在药学上可接受的载体中的组合物；以及在胃肠道诊断放射学中使用它们的方法。
• Compositions of iodophenoxy alkanes and iodophenyl ethers in
  申请人：Sterling Winthrop Inc.

  公开号：US05326553A1

  公开（公告）日：1994-07-05

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy, (CR.sub.1 R.sub.2).sub.p-- (CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl in a pharmaceutically acceptable carrier.

  本发明公开了用于口服或逆行检查胃肠道的X线造影剂组合物，包括能够在胃肠道形成涂层的聚合物材料和具有以下公式的X射线产生剂：##STR1##以及在胃肠道的诊断放射学中使用它们的方法，其中Z = H，卤素，C.sub.1-C.sub.20烷基，环烷基，较低烷氧基，氰基，其中烷基和环烷基可以被卤素或卤素-较低烷基基团取代；R = C.sub.1-C.sub.25烷基，环烷基或卤素-较低烷基，可选地被卤素，氟-较低烷基，芳基，较低烷氧基，羟基，羧基，较低烷氧基羰基或较低烷氧羰氧基取代，(CR.sub.1 R.sub.2).sub.p--(CR.sub.3.dbd.CR.sub.4).sub.m Q或(CR.sub.1 R.sub.2).sub.p--C.tbd.C--Q；R.sub.1，R.sub.2，R.sub.3和R.sub.4独立地是较低烷基，可选地被卤素取代；x为1-4；n为1-5；m为1-15；p为1-10；Q为H，较低烷基，较低烯基，较低炔基，较低烷基，芳基或芳基-较低烷基，以及在药学上可接受的载体中。