1-(2-amino-4-methylthiazol-5-yl)ethanone hydrochloride | 106012-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-amino-4-methylthiazol-5-yl)ethanone hydrochloride
• 英文别名: 1-(2-Amino-4-methyl-thiazol-5-yl)-aethanon; Hydrochlorid；1-(2-Amino-4-methyl-1,3-thiazol-3-ium-5-yl)ethanone;chloride；1-(2-amino-4-methyl-1,3-thiazol-3-ium-5-yl)ethanone;chloride
• CAS: 106012-40-2
• 化学式: C₆H₈N₂OS*ClH
• mdl: MFCD00159784
• 分子量: 192.669
• InChiKey: UCVFFZTUHMGPJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.31
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-amino-4-methylthiazol-5-yl)ethanone hydrochloride 在 4-二甲氨基吡啶 、 一水合肼 、 三乙胺 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 18.92h， 生成
  参考文献：
  名称：

  一种酯基吡唑联噻唑胺化合物及其制备方法和应用

  摘要：

  本发明公开了一种酯基吡唑联噻唑胺化合物及其制备方法和应用，其结构通式为：。该化合物是一种双五元氮杂环双官能团化合物，便于实现噻唑胺和吡唑的高通量合成和多样化衍生，可广泛应用于噻唑联吡唑类药物研发和生产中。

  公开号：

  CN111606902A
• 作为产物：
  描述：

  3-氯-2,4-戊二酮 、 硫脲 生成 1-(2-amino-4-methylthiazol-5-yl)ethanone hydrochloride
  参考文献：
  名称：

  CHUJGUK, V. A.;NAZARENKO, K. G., YKP. XIM. ZH., 1986, 52, N 1, 82-84

  摘要：

  DOI：

文献信息

• A One-pot, Four-component Protocol for the Synthesis of 2-Aroylimino-3-aryl-4-methyl-5-acetyl-1,3-thiazolines
  作者：Aamer Saeed、Ulrich Flörke

  DOI：10.1002/jhet.2180

  日期：2015.5

  A concise and efficient route for the synthesis of new 2‐aroylimino‐3‐aryl‐4‐methyl‐5‐acetyl‐1,3‐thiazolines in good to excellent yields is described. This involves the one‐pot, four‐component reaction of suitable aroyl chlorides, potassium thiocyanate, anilines, and 3‐chloropentane‐2,4‐dione in the presence of N‐methylimidazole.

  描述了一种简捷有效的合成新的2-芳基亚胺基3-芳基-4-甲基-5-乙酰基-1,3-噻唑啉的方法，该方法具有良好的收率。这涉及在N-甲基咪唑存在下合适的芳酰氯，硫氰酸钾，苯胺和3-氯戊烷-2,4-二酮的一锅四组分反应。
• Thiazole derivatives to counter advanced glycation
  申请人：Avon Products, Inc.

  公开号：EP1543824A2

  公开（公告）日：2005-06-22

  Methods are disclosed for improving the appearance of skin by topical administration of thiazole derivatives which inhibit the formation of advanced glycation endproducts, break advanced glycation endproduct-associated crosslinks, and inhibit the function of glucose oxidase. Cosmetic and pharmaceutical compositions comprising the thiazole derivatives are also disclosed.

  本发明公开了通过局部施用噻唑衍生物来改善皮肤外观的方法，噻唑衍生物可抑制高级糖化终产物的形成、断裂高级糖化终产物相关的交联以及抑制葡萄糖氧化酶的功能。此外，还公开了包含噻唑衍生物的化妆品和药物组合物。
• Thiazole derivatives
  申请人：Hines D. Michelle

  公开号：US20050137239A1

  公开（公告）日：2005-06-23

  Methods are disclosed for improving the appearance of skin by topical administration of thiazole derivatives which inhibit the formation of advanced glycation endproducts, break advanced glycation endproduct-associated crosslinks, and inhibit the function of glucose oxidase. Cosmetic and pharmaceutical compositions comprising the thiazole derivatives are also disclosed.

  本发明公开了通过局部施用噻唑衍生物来改善皮肤外观的方法，噻唑衍生物可抑制高级糖化终产物的形成、断裂高级糖化终产物相关的交联以及抑制葡萄糖氧化酶的功能。此外，还公开了包含噻唑衍生物的化妆品和药物组合物。
• Pyrazolylthiazole as ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Correctors with Improved Hydrophilicity Compared to Bithiazoles
  作者：Long Ye、John M. Knapp、Panjamaporn Sangwung、James C. Fettinger、A. S. Verkman、Mark J. Kurth

  DOI：10.1021/jm100235h

  日期：2010.5.13

  Deletion of phenylalanine residue 508 (Delta F508) in the cystic fibrosis (CF) transmembrane conductance regulator protein (CFTR) is a major cause of CF. Small molecule "correctors" of defective A Delta 508-CFTR cellular processing hold promise for CF therapy. We previously identified and characterized bithiazole CF corrector 1 and s-cis-locked bithiazole 2. Herein, we report the regiodivergent synthesis of N gamma and N beta isomers of thiazole-tethered pyrazoles with improved hydrophilicity compared to bithiazoles. We synthesized a focused library of 54 pyrazolylthiazoles 3, which included examples of both regioisomers 4 and 5. The thiazole-tethered pyrazoles allowed incorporation of property-modulating functionality on the pyrazole ring (ester, acid, and amide) while retaining Delta F508-CFTR corrector activity (EC50) of under 1 mu M. The most active pyrazolylthiazole (14h) has an experimentally determined log P of 4.1, which is 1.2 log units lower than bithiazole CF corrector 1.
• Suciu,D., Journal fur praktische Chemie (Leipzig 1954), 1971, vol. 313, p. 193 - 204
  作者：Suciu,D.

  DOI：——

  日期：——