(E)-6-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-octa-2,7-dienoic acid ethyl ester | 157131-32-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E)-6-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-octa-2,7-dienoic acid ethyl ester
• 英文别名: ethyl (2E)-6-[tert-butyl(dimethyl)silyl]oxy-2,6-dimethylocta-2,7-dienoate
• CAS: 157131-32-3
• 化学式: C₁₈H₃₄O₃Si
• 分子量: 326.552
• InChiKey: DJBZAMSGPSNUGO-FYWRMAATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.24
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-6-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-octa-2,7-dienoic acid ethyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以83%的产率得到(E)-6-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-octa-2,7-dienoic acid
  参考文献：
  名称：

  Synthesis of (±)-(E)-2,6-dimethyl-6-hydroxyocta-2,7-dienoic acid and the corresponding amide (“acacialactam”)

  摘要：

  The total synthesis of the title compounds in racemic form is described. Linalool was used as the starting material and transformed into the target molecules in 6 steps. The synthetic amide displays spectral properties identical to those reported for the natural compound acacialactam, indicating that the structure proposed for the latter compound is not correct.

  DOI：

  10.1016/s0040-4039(00)76907-3
• 作为产物：
  描述：

  芳樟醇 在 吡啶 、 lutidine 、 臭氧 、 苯甲酸 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 26.75h， 生成 (E)-6-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-octa-2,7-dienoic acid ethyl ester
  参考文献：
  名称：

  Synthesis of (±)-(E)-2,6-dimethyl-6-hydroxyocta-2,7-dienoic acid and the corresponding amide (“acacialactam”)

  摘要：

  The total synthesis of the title compounds in racemic form is described. Linalool was used as the starting material and transformed into the target molecules in 6 steps. The synthetic amide displays spectral properties identical to those reported for the natural compound acacialactam, indicating that the structure proposed for the latter compound is not correct.

  DOI：

  10.1016/s0040-4039(00)76907-3

文献信息

• Synthesis of (±)-(E)-2,6-dimethyl-6-hydroxyocta-2,7-dienoic acid and the corresponding amide (“acacialactam”)
  作者：Miguel Carda、Juan Murga、J.Alberto Marco

  DOI：10.1016/s0040-4039(00)76907-3

  日期：1994.5

  The total synthesis of the title compounds in racemic form is described. Linalool was used as the starting material and transformed into the target molecules in 6 steps. The synthetic amide displays spectral properties identical to those reported for the natural compound acacialactam, indicating that the structure proposed for the latter compound is not correct.