(1S,2R,3R,4S,5R,7R,8S,9R,10R)-3,4,5,6,6,7-hexachloropentacyclo[6.3.0.02,4.03,7.05,9]undecane-10-carbaldehyde | 7421-93-4

• 物质功能分类: 化学农药原药 - 杀虫剂 - 有机氯杀虫剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,2R,3R,4S,5R,7R,8S,9R,10R)-3,4,5,6,6,7-hexachloropentacyclo[6.3.0.02,4.03,7.05,9]undecane-10-carbaldehyde
• CAS: 7421-93-4
• 化学式: C₁₂H₈Cl₆O
• 分子量: 380.9
• InChiKey: HCTWZIFNBBCVGM-YFQUMFGZSA-N

物化性质

• 沸点：
  435.2±45.0 °C(Predicted)
• 密度：
  1.86±0.1 g/cm3(Predicted)
• 闪点：
  11 °C
• 物理描述：
  Endrin aldehyde is a solid.
• 熔点：
  Melting point: 235 °C, with decomposition
• 溶解度：
  In water 2.4X10-2 mg/L at 25 °C
• 蒸汽压力：
  2X10-7 mm Hg at 25 °C
• 亨利常数：
  Henry's Law constant = 4.2X10-6 atm-cu m/mole at 25 °C /Estimated/
• 稳定性/保质期：
  STABLE IN PRESENCE OF MOST ALKALIES
• 气味阈值：
  Odor threshold: 0.041 mg/L (water); 1.8 x 10-2 ppm (air) /Endrin/ /from table/

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

毒理性

• 解毒与急救

治疗是对症和支持性的。不应使用油作为泻药或皮肤清洁剂，因为它们会增加吸收。对于摄入，应进行胃灌洗和使用活性炭和硫酸钠。如果发生皮肤暴露，应去除受污染的衣物，并用肥皂和水彻底清洁皮肤。儿童和成人的癫痫管理使用的是安定或苯巴比妥。特别是在儿童中使用安定和苯巴比妥时，可能会出现呼吸抑制甚至呼吸停止。这些药物最好只在可以进行紧急气管插管的重症监护区使用。... 对于有机氯中毒的患者，不能使用肾上腺素，因为有机氯化物会引起心肌兴奋性和室性心律失常。然而，在液体管理无反应的低血压情况下，可能需要使用多巴胺，在心肺骤停的情况下，可能需要使用肾上腺素。... 在病因因素尚未明确的重症昆虫剂暴露患者中，不应推迟试用阿托品和新斯的明，因为这些药物在有机磷中毒中可能证明是救命稻草。必须谨慎使用阿托品，因为它可能引起室性兴奋性，特别是在存在如有机氯化物这样的心肌刺激物时。... 在急性林丹或其他有机氯化物中毒的情况下，应进行至少48至72小时的血液学、肝脏（特别是对剧毒的异狄氏剂）、肾脏研究以及心肺监测。对于林丹中毒的患者，需要长期的血液学随访。由于这些物质的载体可能是二甲苯或石油馏分，管理还必须包括对这些实体的观察和治疗。/有机氯杀虫剂/

Treatment is symptomatic and supportive. Oils should not be used as either cathartics or dermal cleansing agents, as they increase absorption. Gastric lavage and use of activated charcoal and sodium sulfate are indicated for ingestion. If dermal exposure occurred, contaminated clothes should be removed, and the skin should be thoroughly cleansed with soap and water. Management of seizures in both children and adults is with Valium or phenobarbital. Respiratory depression and even respiratory arrest especially with concomitant use of Valium and phenobarbital in children, may occur. These drugs preferably should be used only in critical care areas where emergency endotracheal intubation can be performed. ... Epinephrine can not be utilized in patients with organochlorine posioning, as the organochlorines induce myocardial irritability and ventricular arrhythmias may occur. However, dopamine may be necessary in the event of hypotension unresponsive to fluid administration, and epinephrin may be necessary in the event of cardiopulmonary arrest. ... In a critically ill patient with unknown insecticide exposure, a trial of atropine and pralidoxime should not be withheld until the etiologic agent is discovered, for the use of these agents may prove life-saving in organophosphate poisoning. Atropine must be used with caution, as it can cause ventricular irritability, especially when a mycardial irritant such as an organochlorine is present. ... Hematologic, hepatic (especially with endrin, which is markedly hepatotoxic), and renal studies as well as cardiopulmonary monitoring should be carried out in acute intoxication from lindane or other organochlorines for at least 48 to 72 hr. Long term hematologic follow-up is necessary for the patient with lindane intoxication. As the carrier for these agents may be xylene or a petroleum distillate, management also must include observation and treatment for these entities. /Organochlorine pesticides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 医疗监测

初次医学检查：全面病史和体格检查：目的是检测可能使接触员工风险增加的现有状况，并为未来的健康监测建立基线。有癫痫病史的人预计会因接触而增加风险。应强调神经系统和肝脏的检查。血液中狄氏剂浓度有助于确定吸收程度。上述医学检查应每年重复一次。/狄氏剂/

Initial Medical Examination: A complete history and physical examination: The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Persons with a history of convulsive disorders would be expected to be at increased risk from exposure. Examination of the nervous system and liver should be stressed. The concentration of endrin in the blood is helpful in determining the extent of absorption. The aforementioned medical examination should be repeated on an annual basis. /Endrin/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

有机氯杀虫剂引起的神经兴奋导致其主要毒性表现。有机氯杀虫剂中毒综合症包括感觉、协调和精神状态的障碍。急性有机氯杀虫剂中毒报告了厌食、不适、头痛、肌阵挛性抽搐、嗜睡、震颤、反射亢进、运动过度兴奋、口腔感觉异常（摄入后）和癫痫发作。高浓度的有机氯农药与心肌兴奋性增加和心律失常有关。/有机氯杀虫剂/

/SIGNS AND SYMPTOMS/ The neural excitation caused by the organochlorine insecticides leads to their primary toxic manifestations. The organochlorine insecticide toxicity syndrome includes disturbances of sensation, coordination, and mental status. Anorexia, malaise, headaches, myoclonic jerking, lethargy, tremor, hyperreflexia, motor hyperexcitability, oral paresthesia (after ingestion), and convulsions have been reported with acute organochlorine insecticide poisoning. High concentrations of organochlorine pesticides have been associated with increased myocardial irritability and cardiac arrhythmias. /Organochlorine insecticides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验动物：亚慢性或前慢性暴露/六只雄性和六只雌性 Sprague-Dawley 大鼠被喂食对照饮食或含有 5 或 10 毫克/千克的艾氏剂、10 毫克/千克的艾氏剂醛、或 5 毫克/千克的艾氏剂酮的饮食，持续 15 天。在第 16 天，每个处理组的 3 到 6 只大鼠通过腹膜内单次给药的方式接受玉米油中的四氯化碳（1 毫克/千克体重，剂量为 100 微升/千克）。测量血清酶水平、胆汁流量和阴离子模型化合物酚酞葡萄糖苷酸的胆汁排泄。艾氏剂醛的饮食处理略微增加了血清谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶的水平；并且...胆汁流量或胆汁中酚酞葡萄糖苷酸的排泄/没有改变/。与四氯化碳结合时，一些血清酶的水平（增加两倍）高于单独使用艾氏剂醛或酮或仅使用四氯化碳时的水平。

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Six male and six female Sprague-Dawley rats were fed a control diet or diets containing endrin at 5 or 10 mg/kg, endrin aldehyde at 10 mg/kg, or endrin ketone at 5 mg/kg for 15 days, at which time three to six rats from each treatment group were given a single intraperitoneal dose of carbon tetrachloride at 100 uL/kg body weight in corn oil (1 mg/kg). Levels of serum enzymes, bile flow, and biliary excretion of an anionic model compound, phenolphthalein glucuronide, were measured on day 16. ...Dietary treatment with endrin aldehyde slightly increased the levels of serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase; and ...bile flow or biliary phenolphthalein glucuronide excretion /was not altered/. Combination with carbon tetrachloride increased the levels of some serum enzymes (two-fold) over those seen with the aldehyde or the ketone or carbon tetrachloride alone.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：亚慢性或前慢性暴露...老鼠被喂食对照饮食或含有5或10 ppm异狄氏剂、10 ppm异狄氏剂醛或5 ppm异狄氏剂酮的饮食15天。...在任一剂量水平上，异狄氏剂饮食处理并未显著提高血清酶水平，而异狄氏剂醛在SGOT和SGPT上产生了轻微的增加，异狄氏剂酮在SGPT水平上产生了小幅升高。异狄氏剂醛或异狄氏剂酮的处理并未导致胆汁流量或胆汁PG排泄的显著改变。...异狄氏剂或异狄氏剂衍生物的处理并未增强CCl4诱导的肝胆功能的改变。

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ ... Rrats were given control diet or diets containing 5 or 10 ppm endrin, 10 ppm endrin aldehyde or 5 ppm endrin ketone for 15 days. ... Dietary treatment with endrin at either dose level did not significantly elevate serum enzyme levels, while endrin aldehyde produced a slight increase in SGOT and SGPT and endrin ketone produced a small elevation in SGPT levels. Treatment with endrin aldehyde or endrin ketone did not result in significant alterations of bile flow or biliary PG excretion. ... Treatment with the endrin or endrin derivative did not potentiate CCl4-induced alterations in hepatobiliary functions.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  Xn,F,T
• 安全说明：
  S16,S36/37,S45,S7
• 危险类别码：
  R22,R39/23/24/25,R11,R23/24/25
• WGK Germany：
  3
• 危险品运输编号：
  UN 2761
• 包装等级：
  III
• 危险类别：
  6.1(b)