Photo‐Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to
<i>β</i>
‐Ketosulfones
作者:Jie Chen、Zoe G. Allyson、Jing‐Rui Xin、Zhi Guan、Yan‐Hong He
DOI:10.1002/adsc.201901525
日期:2020.5.12
synthetically and biologically relevant β‐ketosulfones via a photo‐mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal‐free conditions, good functional group compatibility, readily available starting materials and the use of ubiquitous dioxygen as both oxygen source and oxidant. Furthermore, mechanistic studies reveal that the decarboxylative ketonization
公开了通过无光子酸的光介导的脱羧酮化作用,有效形成合成和生物学上相关的β-酮砜的方法。该方法的特点是无金属条件,良好的官能团相容性,易于获得的原料以及使用普遍存在的双氧作为氧源和氧化剂。此外,机理研究表明,脱羧酮化反应是通过自由基机理进行的,并且可能涉及自由基链反应。