methyl allylcyclohexylcarbinyl ether | 125310-49-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl allylcyclohexylcarbinyl ether
• 英文别名: (1-methoxybut-3-en-1-yl)cyclohexane；(1-methoxy-3-butenyl)cyclohexane；(1-methoxybut-3-enyl)cyclohexane；1-cyclohexyl-1-methoxy-3-butene；4-cyclohexyl-4-methoxybut-1-ene；1-Methoxybut-3-enylcyclohexane
• CAS: 125310-49-8
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: GEYOZLMZIQSBSO-UHFFFAOYSA-N

物化性质

• 沸点：
  213.4±19.0 °C(Predicted)
• 密度：
  0.871±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  methyl allylcyclohexylcarbinyl ether 在 sodium hydroxide 、 臭氧 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.33h， 以56%的产率得到methyl 3-cyclohexyl-3-methoxypropanoate
  参考文献：
  名称：

  Oxidative cleavage of mono-, di-, and trisubstituted olefins to methyl esters through ozonolysis in methanolic sodium hydroxide

  摘要：

  The ozonolysis of alkenes in methanolic NaOH or NaOMe with CH2Cl2 as cosolvent leads directly to methyl esters. The procedure has been used to prepare various alpha-, beta, and omega-alkoxy esters, acyloxy esters, and alpha- and beta-N-acyl and N-sulfonyl esters from the appropriate unsaturated ethers, esters, and amides. Other examples include the formation of dimethyl octanedioate from cyclooctene (75% yield), dimethyl nonanedioate and methyl nonanoate from methyl oleate (77 and 78%, respectively), and tetradecanoic acid gamma-lactone from 2-methyl-2-hexadecen-6-ol (80% yield).

  DOI：

  10.1021/jo00066a019
• 作为产物：
  描述：

  溴代环己烷 在 三氟甲磺酸 、 tetrabutylammonium tetrafluoroborate 、 仲丁基锂 作用下， 以 四氢呋喃 、 二氯甲烷 、 环己烷 为溶剂， 反应 1.34h， 生成 methyl allylcyclohexylcarbinyl ether
  参考文献：
  名称：

  烷氧基碳鎓离子的电氧化生成和积累及其与碳亲核试剂的反应

  摘要：

  DOI：

  10.1021/ja002123p

文献信息

• Direct and indirect electrochemical generation of alkoxycarbenium ion pools from thioacetals
  作者：Kouichi Matsumoto、Koji Ueoka、Shinkiti Suzuki、Seiji Suga、Jun-ichi Yoshida

  DOI：10.1016/j.tet.2009.09.020

  日期：2009.12

  Thioacetals were found to be effective precursors to generate and accumulate alkoxycarbenium ions based on direct and indirect cation pool methods. Alkoxycarbenium ions thus generated reacted with carbon nucleophiles such as allylsilanes and enol silyl ethers to give C–C bond formation products in good yields.

  基于直接和间接阳离子池方法，发现硫缩醛是产生和积累烷氧基碳鎓离子的有效前体。这样产生的烷氧碳鎓离子与碳亲核试剂（例如烯丙基硅烷和烯醇甲硅烷基醚）反应，以高收率得到C–C键形成产物。
• Facile Preparation of Allylzinc Species from Allyl Bromides and Unactivated Zinc Induced by a Catalytic Amount of Aluminum Chloride and Their Reactions with Carbonyl Compounds and Acetals.
  作者：Hatsuo MAEDA、Kazushige SHONO、Hidenobu OHMORI

  DOI：10.1248/cpb.42.1808

  日期：——

  The effects of Lewis acids (ZnCl2, AlCl3, BF3, and TiCl4) on the generation of allylzinc species from allyl bromide and unactivated zinc powder in dry tetrahydrofuran (THF) were examined by trapping the organozinc compound with benzaldehyde, that is, Grignard-type allylation of the aldehyde. Among the Lewis acids employed, AlCl3, was found to be the promoter of choice. The allylzinc species preformed in the presence of a catalytic amount of AlCl3 effectively allylated carbonyl compounds. Various aromatic and aliphatic aldehydes as well as ketones were converted into homoallylic alcohols in good to excellent yields. Under the reaction conditions employed, ester, hydroxy, acetal, and aromatic nitro and halide groups were tolerated. In the case of α, β-unsaturated carbonyl compounds, selective 1, 2-addition was observed. Substituted allyl bromides such as prenyl, crotyl, cinnamyl, and 2-cyclohexenyl bromides were smoothly converted to the corresponding allylzinc compounds, which reacted with carbonyl compounds to give substituted homoallylic alcohols in excellent yields. The diastereoselectivity in crotylation, cinnamylation, and 2-cyclohexenylation depended upon the structures of both the organic metals and the electrophiles. The origin of the observed selectivity is discussed. The allylation of dimethyl and cyclic acetals accompanied with carbon-oxygen bond cleavege also proceeded in excellent yields provided that two equivalents of AlCl3 was present.

  在干燥的四氢呋喃（THF）中，研究了路易斯酸（ZnCl2、AlCl3、BF3和TiCl4）对烯丙基溴和未活化的锌粉生成烯丙基锌物种的影响，并通过苯甲醛捕获有机锌化合物，即醛的格氏型烯丙基化反应。在所用的路易斯酸中，AlCl3被发现是最优的促进剂。在催化量的AlCl3存在下预形成的烯丙基锌物种能有效地烯丙基化羰基化合物。各种芳香族和脂肪族醛以及酮被转化为同烯丙基醇，产率良好至优秀。在所采用的反应条件下，酯、羟基、缩醛以及芳香族硝基和卤素基团均被容忍。对于α,β-不饱和羰基化合物，观察到了选择性的1,2-加成。取代的烯丙基溴如香叶基、巴豆基、肉桂基和2-环己烯基溴均能顺利转化为相应的烯丙基锌化合物，这些化合物与羰基化合物反应生成取代的同烯丙基醇，产率极佳。在巴豆基化、肉桂基化和2-环己烯基化中的立体选择性取决于有机金属和亲电试剂的结构。讨论了观察到的选择性的起源。在AlCl3的两当量存在下，伴随着碳-氧键断裂的二甲基和环状缩醛的烯丙基化也以极佳的产率进行。
• Catalytic Use of Elemental Gallium for Carbon–Carbon Bond Formation
  作者：Bo Qin、Uwe Schneider

  DOI：10.1021/jacs.6b06767

  日期：2016.10.12

  The first catalytic use of Ga(0) in organic synthesis has been developed by using a Ag(I) cocatalyst, crownether ligation, and ultrasonic activation. Ga(I)-catalyzed C-C bond formations between allyl or allenyl boronic esters and acetals, ketals, or aminals have proceeded in high yields with essentially complete regio- and chemoselectivity. NMR spectroscopic analyses have revealed novel transient Ga(I)

  Ga(0) 在有机合成中的首次催化应用是通过使用 Ag(I) 助催化剂、冠醚连接和超声活化开发的。Ga(I) 催化的烯丙基或丙二烯基硼酸酯与缩醛、缩酮或胺缩醛之间的 CC 键形成以高产率进行，具有基本上完全的区域选择性和化学选择性。核磁共振光谱分析揭示了新的瞬态 Ga(I) 催化物质，分别通过 Ga(0) 和 B-Ga 金属转移的部分氧化原位形成。已经证明了不对称 Ga(I) 催化的可能性。
• Indirect Cation-Flow Method: Flash Generation of Alkoxycarbenium Ions and Studies on the Stability of Glycosyl Cations
  作者：Kodai Saito、Koji Ueoka、Kouichi Matsumoto、Seiji Suga、Toshiki Nokami、Jun-ichi Yoshida

  DOI：10.1002/anie.201100854

  日期：2011.5.23

  Go with the flow: The indirect cation‐flow method based on the generation of highly reactive organic cations from their precursors using electrochemically generated [ArS(ArSSAr)]+ was developed in flow microreactor systems (see scheme; Bn=benzyl, M=micromixer, R=microtube reactor). The method was applied to evaluate glycosyl cations such as A or their equivalents and glycosylation reactions.

  顺其自然：基于从它们的前体使用电化学产生[ARS（ArSSAr）]高反应性的有机阳离子的生成的间接阳离子流法+是在流动的微反应器系统而开发的（见方案; BN =苄基，M =微混合器，R ＝微管反应器）。该方法用于评估糖基阳离子（例如A或它们的等价物）和糖基化反应。
• (2,7-Disubstituted-1,8-biphenylenedioxy)bis(dimethylaluminum) as Bidentate Organoaluminum Lewis Acids:  Elucidation and Synthetic Utility of the Double Electrophilic Activation Phenomenon
  作者：Takashi Ooi、Makoto Takahashi、Masao Yamada、Eiji Tayama、Kiyoyuki Omoto、Keiji Maruoka

  DOI：10.1021/ja030552s

  日期：2004.2.1

  temperature; this primarily relies on the successful establishment of a new synthetic procedure of 1 starting from inexpensive m-anisidine. Evaluation of 2 as a bidentate organoaluminum Lewis acid has been performed by the reduction of ketonic substrates using Bu3SnH as a hydride source in comparison to the conventional monodentate Lewis acid dimethylaluminum 2,6-xylenoxide (11), uncovering the significantly

  通过用 Me3Al 处理必需的 2,7-二取代-1,8-联苯二醇 (1)，可以很容易地原位制备一系列 (2,7-二取代-1,8-联苯二氧基) 双(二甲基铝) (2) （2 当量）在室温下的 CH2Cl2 中；这主要依赖于从廉价的间茴香胺开始成功建立 1 的新合成程序。与传统的单齿路易斯酸二甲基铝 2,6-二甲苯氧化物 (11) 相比，通过使用 Bu3SnH 作为氢化物源还原酮底物，对 2 作为双齿有机铝路易斯酸进行了评估，揭示了 2 的显着高活化能力向羰基。特别是，（2,7-二甲基-1,8-联苯二氧基）双（二甲基铝）（2a）发挥了最高的反应性，这在向山羟醛反应中也得到了强调。双齿路易斯酸 2 的结构通过对具有大体积 3,5-二叔丁基苯基取代基的 2g 的单晶 X 射线衍射分析明确确定，揭示了固态的刚性二聚体组装。2a 对羰基底物的双亲电活化得到了低温 13C NMR 分析以及使用 Gaussian