1-(4-tetradecyloxyphenyl)-ethanone | 52244-88-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-tetradecyloxyphenyl)-ethanone
• 英文别名: 4-tetradecyloxyacetophenone；Ethanone, 1-[4-(tetradecyloxy)phenyl]-；1-(4-tetradecoxyphenyl)ethanone
• CAS: 52244-88-9
• 化学式: C₂₂H₃₆O₂
• 分子量: 332.527
• InChiKey: BJIVEFYEHPBIEC-UHFFFAOYSA-N

物化性质

• 熔点：
  58-59 °C(Solv: ethanol (64-17-5))
• 沸点：
  448.9±18.0 °C(Predicted)
• 密度：
  0.924±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-tetradecyloxyphenyl)-ethanone 在 盐酸 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  Coordination behaviour of new dipyridylpyrazole ligands towards ZnCl₂and PdCl₂fragments. Crystalline structural characterization and multinuclear NMR studies as evidence of linkage and conformational isomers

  摘要：

  包含二吡啶吡唑配体的新型金属配合物被研究作为异构体的高效示例。

  DOI：

  10.1039/c3ra45821k
• 作为产物：
  描述：

  苯酚 在 高氯酸 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.5h， 生成 1-(4-tetradecyloxyphenyl)-ethanone
  参考文献：
  名称：

  Liquid crystalline N-aryl-β-aminovinyl ketones and their complexes with lanthanides

  摘要：

  Liquid crystalline lanthanide complexes with N-aryl-substituted beta-aminovinyl ketones were synthesized for the first time. The complexes give rise to smectic A mesophase and are stable only in the solid state; in going to solution, they dissociate with formation of the initial ligand.

  DOI：

  10.1134/s1070363206070152

文献信息

• Mesogenic heterocycles formed by bis-pyrazoles and bis-1,3,4-oxadiazoles
  作者：Kuan-Ting Lin、Gene-Hsiang Lee、Chung K. Lai

  DOI：10.1016/j.tet.2015.04.055

  日期：2015.6

  Three new series of compounds 1a–c containing multiple heterocyclic 2,5-pyrazoles, 1,3,4-oxadiazole and thiophene exhibiting mesophases were reported. Crystallographic data showed that the crystal 1a (n=8) is a linear-shaped molecule with a molecular length of ca. 40.57 Å. However, three heterocyclic rings were not coplanar. All compounds 1a formed smectic A/C phases, and all compounds 1c exhibited columnar

  报道了三个新的系列化合物1a – c，其中包含多个显示中间相的杂环2,5,5-吡唑，1,3,4-恶二唑和噻吩。晶体学数据表明，晶体1a（n = 8）是线型分子，分子长为。40.57Å。但是，三个杂环不是共面的。所有化合物1a均形成近晶A / C相，并且所有化合物1c均显示出柱状相，这通过粉末X射线衍射仪（XRD）证实。对于导数1c，在9.0埃厚的切片中获得了一个N电池，R ar值等于3.91和18.29Å（n = 8），表明在Col h相的列内两个分子是相关的。通过热重分析（TGA），所有衍生物在T = 383–426°C以下的温度下均表现出良好的稳定性。所有化合物的PL光谱图1b - Ç（Ñ = 8）显示出一个强峰在λ最大= 428-496纳米，且这些光致发光发射（PL）源自1,3,4-恶二唑基部分。
• Fluorescent columnar bis(boron difluoride) complexes derived from tetraketonates
  作者：Ya-Wen Chen、Yen-Chun Lin、Hsiu-Ming Kuo、Chung K. Lai

  DOI：10.1039/c7tc01425b

  日期：——

  of bis-(boron difluoride) complexes 1a–c derived from substituted tetraketonates 2a–c are reported, and their mesomorphic and optical properties have been investigated. Two single crystals of mesogenic ligand 2a (n = 6) and nonmesogenic diboron complex 1a (n = 14) were obtained, and their single crystal and molecular structures were resolved. Results show that all 2a ligands (n = 6, 8, 10, 12, 14) formed

  据报道，由取代的四酮酸酯2a-c衍生出三个新的双-（二氟化硼）配合物1a-c系列，并研究了它们的介晶和光学性质。获得了两个介晶配体2a（n = 6）和非介晶二硼配合物1a（n = 14）的单晶，并解析了它们的单晶和分子结构。结果表明，所有2a配体（n = 6、8、10、12、14）均形成向列和/或近晶C相。但是，所有2b–c化合物都不是介晶的。相反，bis（BF 2）络合物1a–b是非介晶的，1c（n = 8、10、12）表现出对映体柱状中间相。对于化合物1c，在9.0埃厚的柱层中获得了N cell = 2.70–2.86 ，这表明在Col h相中，单个盘状分子堆叠在柱中。在室温下，Bis（BF 2）络合物1a–c（n = 8）在溶液中具有明显的黄红色发射。发光发射显示对结构部分有很强的依赖性结合，与λ最大= 538（1A）<641（图1b）<708纳米（1C）。据我们所知，这是柱状bis（BF
• Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives
  作者：Toshio Watanabe、Kimiaki Hayashi、Shigeki Yoshimatsu、Kazuo Sakai、Shigeyuki Takeyama、Kohki Takashima

  DOI：10.1021/jm00175a010

  日期：1980.1

  and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate. The proper length (C12--C16) and the para position of the alkoxy substituent seem to be essential for activity. Chloroethyl

  合成了110多种烷氧基肉桂酸衍生物，并在大鼠筛选系统中评估了它们的降血脂活性。发现肉桂酸，α-甲基肉桂酸及其各种具有较高对烷氧基取代基的酯具有比氯贝贝特更高或相当的降血脂活性。适当的长度（C12-C16）和烷氧基取代基的对位似乎对活性至关重要。一些活性对烷氧基肉桂酸的氯乙基和甲基丙烯酰氧基乙基酯以及甘油单酯比相应的游离酸更具活性。
• 5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids
  作者：Roger A. Parker、Takashi Kariya、J. Martin Grisar、Vladimir Petrow

  DOI：10.1021/jm00216a009

  日期：1977.6

  5-(Tetradecyloxy)-2-furancarboxylic acid (91, RMI 14514) was found to lower blood lipids and to inhibit fatty acid synthesis with minimal effects on liver weight and liver fat content. This fatty acid-like compound represents a new class of hypolipidemic agent; it is effective in rats and monkeys. The compound resulted from discovery of hypolipidemic activity in certain beta-keto esters, postulation

  发现5-（四氢癸氧基）-2-呋喃羧酸（91，RMI 14514）可以降低血脂并抑制脂肪酸合成，对肝脏重量和肝脏脂肪含量的影响最小。这种类似脂肪酸的化合物代表了一类新的降血脂药。对大鼠和猴子有效。该化合物的产生是由于发现了某些β-酮酸酯的降血脂活性，假定和确认了相应的苯甲酸作为活性代谢物以及系统地研究了结构-活性关系。
• Synthesis, Characterization, and Mesomorphic Properties of New Pyridine Derivatives
  作者：Ahipa T. N.

  DOI：10.1002/open.201500158

  日期：2015.12

  Luminescent liquid crystals have received significant research interest due to their wide range of applications. Here, new pyridine derivatives were designed as liquid crystalline materials. They were successfully synthesized via appropriate synthetic routes, their structures confirmed by various spectral techniques, and finally characterized for their mesogenic, optical and optoelectronic properties

  发光液晶由于其广泛的应用而受到了广泛的研究兴趣。在这里，新的吡啶衍生物被设计为液晶材料。它们是通过适当的合成路线成功合成的，其结构已通过各种光谱技术证实，并最终通过介晶，光学和光电特性进行了表征。