quinoline-6-carboxylic acid 4-benzyloxybenzylamide | 849809-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: quinoline-6-carboxylic acid 4-benzyloxybenzylamide
• 英文别名: N-[(4-phenylmethoxyphenyl)methyl]quinoline-6-carboxamide
• CAS: 849809-87-6
• 化学式: C₂₄H₂₀N₂O₂
• 分子量: 368.435
• InChiKey: SXRTYKXADHSQKV-UHFFFAOYSA-N

物化性质

• 沸点：
  638.9±45.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  quinoline-6-carboxylic acid 4-benzyloxybenzylamide 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以17%的产率得到quinoline-6-carbothioic acid 4-benzyloxy-benzylamide
  参考文献：
  名称：

  EP1782811

  摘要：

  公开号：
• 作为产物：
  描述：

  4-苄氧基苄胺 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以100%的产率得到quinoline-6-carboxylic acid 4-benzyloxybenzylamide
  参考文献：
  名称：

  EP1782811

  摘要：

  公开号：

文献信息

• [EN] SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS<br/>[FR] DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE SECONDAIRES ET LEURS UTILISATIONS EN TANT QU'AGENTS ANTIFONGIQUES
  申请人：POLICHEM SA

  公开号：WO2011080265A1

  公开（公告）日：2011-07-07

  The present invention provides secondary 8-hydroxyquinoiine-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulahopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一般式（I）的二级8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体来说，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulahopsis Brevicaulis进行了测试。这些化合物对Candida Albicans和Candida Glabrata等念珠菌物种具有活性。
• [EN] NEW SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES.<br/>[FR] NOUVEAUX DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE SECONDAIRES
  申请人：POLICHEM SA

  公开号：WO2011080266A1

  公开（公告）日：2011-07-07

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopuiariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一种新的通式（I）的次级8-羟基喹啉-7-羧酰胺衍生物及其药物可接受的盐。这些化合物可用作抗真菌剂。具体而言，这些化合物已经对红色毛癣菌、鼠癣菌、黑曲霉和短柄镰刀菌进行了测试。这些化合物中的许多对白色念珠菌如白色念珠菌和光滑念珠菌等具有活性。
• Novel antifungal agent containing heterocyclic compound
  申请人：Nakamoto Kazutaka

  公开号：US20070105943A1

  公开（公告）日：2007-05-10

  The present invention provides an antifungal agent represented by the formula: [wherein A 1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X 1 represents a group represented by the formula —NH—C(═O)—, a group represented by the formula —C(═O)—NH—, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A 1 may have 1 to 3 substituents, and E has one or two substituents].

  本发明提供了一种抗真菌剂，其表示为以下式子： [其中A1表示一个3-吡啶基团，可能具有取代基，喹啉基团，可能具有取代基或类似物；X1表示由公式—NH—C（═O）—，由公式—C（═O）—NH—或类似物表示的基团；E表示呋喃基团，噻吩基团，吡咯基团，苯基团，吡啶基团，四唑基团，噻唑基团或吡唑基团；但A1可能具有1到3个取代基，E具有一个或两个取代基。]
• Novel Antimalarial Agent Containing Heterocyclic Compound
  申请人：Nakamoto Kazutaka

  公开号：US20090227799A1

  公开（公告）日：2009-09-10

  Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A 1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X 1 represents a group represented by the formula —C(═O)—NH— or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A 1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

  揭示了一种抗疟疾剂，其包含由下式表示的化合物： [其中A1表示一个3-吡啶基团，可以有取代基，一个6-喹啉基团，可以有取代基或类似物；X1表示一个由公式-C（═O）-NH-或类似物表示的基团；E表示一个呋喃基团，噻吩基团或苯基团；但前提是A1可以有1到3个取代基，E有两个取代基之一]或其盐或水合物。
• NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND
  申请人：NAKAMOTO Kazutaka

  公开号：US20110195999A1

  公开（公告）日：2011-08-11

  The present invention provides an antifungal agent represented by the formula: wherein A 1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X 1 represents a group represented by the formula —NH—C(═O)—, a group represented by the formula —C(═O)—NH—, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A 1 may have 1 to 3 substituents, and E has one or two substituents.

  本发明提供一种抗真菌剂，其化学式如下： 其中，A1代表3-吡啶基，可以有取代基，喹啉基，也可以有取代基等；X1代表由公式—NH—C（═O）—，由公式—C（═O）—NH—等表示的基团；E代表呋喃基，噻吩基，吡咯基，苯基，吡啶基，四唑基，噻唑基或吡唑基；但要求A1可能有1到3个取代基，E有1或2个取代基。