2,2-dimethoxydecane | 96302-56-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-dimethoxydecane
• CAS: 96302-56-6
• 化学式: C₁₂H₂₆O₂
• 分子量: 202.337
• InChiKey: NVRXATQRFTZPFX-UHFFFAOYSA-N

物化性质

• 沸点：
  221.3±8.0 °C(Predicted)
• 密度：
  0.845±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-dimethoxydecane 在 amberlyst-15 作用下， 以 水 、 丙酮 为溶剂， 反应 5.5h， 以93%的产率得到2-癸酮
  参考文献：
  名称：

  Amberlyst-15, A Superior Acid Catalyst for the Cleavage of Acetals

  摘要：

  DOI：

  10.1055/s-1984-31059
• 作为产物：
  描述：

  2-癸酮 、 原甲酸三甲酯 在 对甲苯磺酸 作用下， 生成 2,2-dimethoxydecane
  参考文献：
  名称：

  An Acetal Acylation Methodology for Producing Diversity of Trihalomethyl- 1,3‑dielectrophiles and 1,2-Azole Derivatives

  摘要：

  A series of functionalized 1,1,1-trihalo-4-methoxy-3-alken-2-ones [CX3C(O)CR1=CROMe, where X = F or Cl; R = n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-tridecyl, (CH2)(2)CH=C(Me)(2), (CH2)(2)Ph, (CH2)(2)-(4-HOC6H4), (CH2)(2)-(4-MeOC6H4), (CH2)(2)CO2Me, (CH2)(3)CO2Me, CH(SMe)CH3, CH2(2-MeOC6H4), and R-1 = H, and R = H and R-1 = n-decyl] were synthesized from respective alkyl methyl ketones or aldehyde via acetal acylation using trifluoroacetic anhydride and trichloroacetyl chloride. 1,1,1-Trihalo-4-methoxy-3-alken-2-ones with acid-compatible substituents were easily hydrolyzed to respective trihalomethyl-1,3-diketones. The 1,1,1-trihalo-4-methoxy-3-alken-2-ones and/or respective trihalomethyl-1,3-diketones were reacted regiospecifically with hydroxylamine hydrochloride, leading to isoxazole derivatives, and with hydrazines, leading to respective 1H-pyrazole derivatives. The structures of all compounds were assigned based on nuclear magnetic resonance (NMR) and mass spectrometric data. This method represents an efficient pathway for the regioselective trihaloacetylation of asymmetrically substituted alkyl methyl ketones and highly self-condensing aldehydes. Moreover, this approach allows the introduction of biologically recognizable moieties, such as those from levulinic acid, sulcatone (prenyl), benzylacetone, anisylacetone, and raspberry ketone, as synthetic molecular targets.

  DOI：

  10.21577/0103-5053.20190160

文献信息

• Long-chain acetals derived from sucrose as a new class of surfactants
  作者：Elisabeth Fanton、Catherine Fayet、Jacques Gelas

  DOI：10.1016/s0008-6215(96)00300-x

  日期：1997.2

  Abstract Classical acetalation and transacetalation of sucrose (α- d -glucopyranosyl β- d -fructofuranoside) with long-chain alkyl carbonyl derivatives lead conveniently to a new class of acetals of great interest, due to their detergent properties.

  摘要具有长链烷基羰基衍生物的蔗糖（α-d-吡喃葡萄糖基β-d-果糖呋喃糖苷）的经典缩醛化和反缩醛化因其去污剂性质而方便地引起了人们的极大兴趣。
• A Fluorinated Cobalt(III) Porphyrin Complex for Hydroalkoxylation of Alkynes
  作者：Richiro Ushimaru、Takuho Nishimura、Toshiki Iwatsuki、Hiroshi Naka

  DOI：10.1248/cpb.c17-00568

  日期：——

  A fluorinated cobalt(III) porphyrin complex [Co(TPFPP)NTf2·2C2H5OH, where TPFPP=5,10,15,20-tetrakis(pentafluorophenyl)porphyrin, Tf=CF3SO2] promotes hydroalkoxylation of alkynes to give acetals in good to excellent yields. The acetals can be directly functionalized with nucleophiles in a one-pot procedure.

  氟化钴（III）卟啉配合物[Co（TPFPP）NTf2·2C2H5OH，其中TPFPP = 5,10,15,20-四（五氟苯基）卟啉，Tf = CF3SO2]可以促进炔烃的加氢烷氧基化，从而以优异的收率获得缩醛。乙缩醛可以一锅法直接用亲核试剂官能化。
• Synthesis of 1,2,4,5,7,8-hexaoxonanes by iodine-catalyzed reactions of bis(1-hydroperoxycycloalkyl) peroxides with ketals
  作者：A. O. Terent’ev、M. M. Platonov、I. B. Krylov、G. I. Nikishin

  DOI：10.1007/s11172-010-0012-8

  日期：2009.2

  Iodine-catalyzed reactions of bis(1-hydroperoxycycloalkyl) peroxides with ketals give, via replacement of two alkoxy groups, the cyclic peroxides, 1,2,4,5,7,8-hexaoxonanes, in up to 82% yields. The cyclization is very sensitive to the solvent nature. Among MeCN, Et2O, THF, CHCl3, CH2Cl2, hexane, and MeOH, the best results were achieved with the first three solvents.

  碘催化双（1-氢过氧环烷基）过氧化物与酮的反应，通过取代两个烷氧基基团，产生了环状过氧化物--1,2,4,5,7,8-六氧羰烷，收率高达 82%。环化反应对溶剂性质非常敏感。在 MeCN、Et2O、THF、CHCl3、CH2Cl2、己烷和 MeOH 溶剂中，前三种溶剂的效果最好。
• IMPROVED PREPARATION OF SURFACTANTS DERIVED FROM SUCROSE WITH ULTRASOUND
  作者：Jacques Besson、Catherine Fayet、J. Gelas、Christelle Lamazzi

  DOI：10.1080/00304949809355311

  日期：1998.8
• COPPOLA, G. M., SYNTHESIS, BRD, 1984, N 12, 1021-1023
  作者：COPPOLA, G. M.

  DOI：——

  日期：——