N-(1-adamantanyl)-2-phenylquinoline-4-carboxamide | 405070-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(1-adamantanyl)-2-phenylquinoline-4-carboxamide
• 英文别名: N-(1-adamantyl)-2-phenylquinoline-4-carboxamide
• CAS: 405070-40-8
• 化学式: C₂₆H₂₆N₂O
• 分子量: 382.505
• InChiKey: VOASWRTWDXGIOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯基-4-喹啉羧酸 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-(1-adamantanyl)-2-phenylquinoline-4-carboxamide
  参考文献：
  名称：

  Facile Synthesis of 2-Phenylquinoline-4-carboxamide Derivatives with Variant Structural Features

  摘要：

  The quinoline scaffold is an important class of heterocyclic compounds that possesses diverse chemotherapeutic activities. Thus, the 2-phenylquinoline-4-carboxamide derivatives containing a variety of moieties, such as 2-(2-furanyl)-1,3,4-oxadiazole, N-(2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidinamine, 4,4'-bithiazole, purine, adamantine and resorcinol, have been designed and synthesized via Suzuki coupling, acid-base coupling and other typical reactions.

  DOI：

  10.3987/com-14-12939

文献信息

• Facile Synthesis of 2-Phenylquinoline-4-carboxamide Derivatives with Variant Structural Features
  作者：Tadashi Okawara、Rafiqul Islam、Md. Imran Hossain、Yoshinari Okamoto、Tomohisa Nagamatsu、Kensaku Anraku

  DOI：10.3987/com-14-12939

  日期：——

  The quinoline scaffold is an important class of heterocyclic compounds that possesses diverse chemotherapeutic activities. Thus, the 2-phenylquinoline-4-carboxamide derivatives containing a variety of moieties, such as 2-(2-furanyl)-1,3,4-oxadiazole, N-(2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidinamine, 4,4'-bithiazole, purine, adamantine and resorcinol, have been designed and synthesized via Suzuki coupling, acid-base coupling and other typical reactions.