1,3-bis(2-phenylquinoline-4-carbonylamino)propane | 438454-53-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,3-bis(2-phenylquinoline-4-carbonylamino)propane
• 英文别名: 2-phenyl-N-[3-[(2-phenylquinoline-4-carbonyl)amino]propyl]quinoline-4-carboxamide
• CAS: 438454-53-6
• 化学式: C₃₅H₂₈N₄O₂
• mdl: MFCD01921184
• 分子量: 536.633
• InChiKey: MXXJHPABDHIJQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-苯基-4-喹啉羧酸 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 1,3-bis(2-phenylquinoline-4-carbonylamino)propane
  参考文献：
  名称：

  Facile Synthesis of 2-Phenylquinoline-4-carboxamide Derivatives with Variant Structural Features

  摘要：

  The quinoline scaffold is an important class of heterocyclic compounds that possesses diverse chemotherapeutic activities. Thus, the 2-phenylquinoline-4-carboxamide derivatives containing a variety of moieties, such as 2-(2-furanyl)-1,3,4-oxadiazole, N-(2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidinamine, 4,4'-bithiazole, purine, adamantine and resorcinol, have been designed and synthesized via Suzuki coupling, acid-base coupling and other typical reactions.

  DOI：

  10.3987/com-14-12939

文献信息

• Facile Synthesis of 2-Phenylquinoline-4-carboxamide Derivatives with Variant Structural Features
  作者：Tadashi Okawara、Rafiqul Islam、Md. Imran Hossain、Yoshinari Okamoto、Tomohisa Nagamatsu、Kensaku Anraku

  DOI：10.3987/com-14-12939

  日期：——

  The quinoline scaffold is an important class of heterocyclic compounds that possesses diverse chemotherapeutic activities. Thus, the 2-phenylquinoline-4-carboxamide derivatives containing a variety of moieties, such as 2-(2-furanyl)-1,3,4-oxadiazole, N-(2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidinamine, 4,4'-bithiazole, purine, adamantine and resorcinol, have been designed and synthesized via Suzuki coupling, acid-base coupling and other typical reactions.