3-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole | 56119-91-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole
• 英文别名: 1-methyl-3-(4-methoxyphenyl)-5-phenylpyrazole；1-methyl-3-p-methoxyphenyl-5-phenylpyrazole；3-p-anisyl-1-methyl-5-phenylpyrazole；3-(4-methoxy-phenyl)-1-methyl-5-phenyl-1H-pyrazole；3-(4-Methoxyphenyl)-1-methyl-5-phenylpyrazole
• CAS: 56119-91-6
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: UBGAFPHYHDSIMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole 在 bis-triphenylphosphine-palladium(II) chloride 、 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 水 、 叔丁醇 为溶剂， 反应 0.83h， 生成 3-(4-methoxyphenyl)-1-methyl-5-phenyl-4-p-tolyl-1H-pyrazole
  参考文献：
  名称：

  快速一锅四步合成高荧光1,3,4,5-四取代吡唑§

  摘要：

  1,3,4,5-四取代的吡唑可以一锅四步的顺序快速有效地合成，该顺序由Sonogashira偶联，加成环缩合，溴化和Suzuki偶联组成。第二步和最后一步是微波辅助的，根据顺序催化，最终步骤无需添加其他Pd催化剂。标题化合物显示出强烈的蓝色荧光和高量子产率。

  DOI：

  10.1021/ol2004947
• 作为产物：
  描述：

  1-methyl-3-p-methoxyphenyl-5-phenylpyrazoline 在 palladium on activated charcoal 溶剂黄146 作用下， 反应 6.0h， 以35%的产率得到3-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole
  参考文献：
  名称：

  Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification

  摘要：

  A parallel synthesis of aryl azoles with neuroprotective activity is described. All compounds obtained were evaluated in an in vitro assay using a NMDA toxicity paradigm showing a neuroprotective activity between 15% and 40%. The potential biological target of the active compounds was investigated by extensive literature searches based around similar scaffolds with reported neuroprotective activity. The most interesting molecules active in the NMDA toxicity assay (3a and 2g) showed moderate but significant activity in the inhibition of the Site 2 Sodium Channel binding assay at 10 mu M. To confirm our hypothesis compounds 3a, c, f and 2g were tested in the Veratridine assay which is one of the excitotoxicity assays of revelance to NaV channels. The compounds tested showed an activity between 40% and 70%. The identification of neuroprotective small molecules and the identification of NaV channels as the potential site of action were the most important goals of this work. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.090

文献信息

• Palladium-Catalyzed Alkynylcarbonylation of Aryl Iodides with the Use of Mo(CO)6 in the Presence oftBu3P Ligand
  作者：Muneaki Iizuka、Yoshinori Kondo

  DOI：10.1002/ejoc.200700700

  日期：2007.11

  Palladium-catalyzed alkynylcarbonylation of aryl iodides was accomplished by using Mo(CO)6 as a CO source. The reaction was conducted at room temperature with the use of tBu3P as a ligand, which was found to be essential for smooth carbonylation. One-pot construction of pyrazoles by using aryl iodides with electron-withdrawing groups was also accomplished under these reaction conditions in the presence

  钯催化的芳基碘化物的炔基羰基化是通过使用 Mo(CO)6 作为 CO 源来完成的。该反应在室温下进行，使用 tBu3P 作为配体，发现这对于顺利羰基化是必不可少的。在甲基肼存在下，在这些反应条件下，还通过使用具有吸电子基团的芳基碘化物完成了吡唑的一锅法构建。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
• Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles from <i>N</i>-Alkylated Tosylhydrazones and Terminal Alkynes
  作者：Yuanfang Kong、Meng Tang、Yun Wang

  DOI：10.1021/ol403447g

  日期：2014.1.17

  An efficient synthesis of 1,3,5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and terminal alkynes was developed. The protocol was applied to a wide range of substrates and demonstrated excellent tolerance to a variety of substituents, including both electron-donating and -withdrawing groups. In comparison with the common approaches for substituted pyrazole syntheses, this methodology proceeded

  开发了由N-烷基化的甲苯磺酰terminal和末端炔烃有效合成1,3,5-三取代的吡唑的方法。该规程适用于多种底物，并表现出对各种取代基（包括供电子基团和吸电子基团）的出色耐受性。与用于取代的吡唑合成的常规方法相比，该方法以完全的区域选择性进行，特别是在R 2和R 3是相似的取代基的情况下。
• Regioselective Three-Component Synthesis of Highly Fluorescent 1,3,5-Trisubstituted Pyrazoles
  作者：Benjamin Willy、Thomas J. J. Müller

  DOI：10.1002/ejoc.200800444

  日期：2008.8

  3,5-Disubstituted and 1,3,5-trisubstituted pyrazoles are readily synthesized from acyl chlorides, terminal alkynes, and hydrazines by a consecutive one-pot three-component Sonogashira coupling/Michael addition/cyclocondensation sequence in good to excellent yields. These pyrazoles are highly fluorescent, both in solution and in the solid state. Investigation of the electronic properties by UV/Vis and

  3,5-二取代和 1,3,5-三取代的吡唑很容易从酰氯、末端炔烃和肼通过连续的一锅三组分 Sonogashira 偶联/迈克尔加成/环缩合序列合成，产率很好。这些吡唑在溶液和固态中都具有很强的荧光性。通过 UV/Vis 和荧光光谱以及 DFT 和 ZINDO CI 计算对电子特性的研究表明，激发态是高度极性的，可以对吸收和发射特性进行微调。3,5-二取代吡唑的 X 射线结构分析揭示了通过氢键和 π 堆积的自组织。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• Aluminum Chloride Mediated Reactions of N-Alkylated Tosyl­hydrazones and Terminal Alkynes: A Regioselective Approach to 1,3,5-Trisubstituted Pyrazoles
  作者：Meng Tang、Yun Wang、Hu Wang、Yuanfang Kong

  DOI：10.1055/s-0035-1561646

  日期：——

  Abstract Aluminum chloride mediated reactions of N-alkylated tosylhydrazones and terminal alkynes are reported. The protocol is applied to a wide range of substrates, and demonstrates excellent functional group tolerance. A series of 1,3,5-trisubstituted pyrazoles is prepared in good to high yields with complete regioselectivity. Aluminum chloride mediated reactions of N-alkylated tosylhydrazones and

  摘要 报道了氯化铝介导的N-烷基化甲苯磺酰and与末端炔烃的反应。该协议适用于广泛的底物，并证明了出色的官能团耐受性。制备了一系列1,3,5-三取代的吡唑类，具有良好的收率，具有很高的区域选择性。 报道了氯化铝介导的N-烷基化甲苯磺酰and与末端炔烃的反应。该协议适用于广泛的底物，并证明了出色的官能团耐受性。制备了一系列1,3,5-三取代的吡唑类，具有良好的收率，具有很高的区域选择性。
• The Preparation of Substituted Pyrazoles from β,β-Dibromo-enones by a Tandem Condensation/Suzuki-Miyaura Cross-Coupling Process
  作者：Richard Taylor、Sandra Beltrán-Rodil、Michael Edwards、David. Pugh、Mark Reid

  DOI：10.1055/s-0029-1218521

  日期：2010.3

  consecutive tandem processes are described for the regioselective, two-step synthesis of 1,3,5-trisubstituted pyrazoles from α-hydroxyketones. The first, a tandem MnO 2 -mediated oxidation/Ramirez olefination reaction, provides a facile route to β,β-dibromo-enones. These valuable 1,3-dicarbonyl synthons can then be converted into 1,3,5-trisubstituted pyrazoles via a second tandem hydrazine condensation/Suzuki-Miyaura

  描述了从 α-羟基酮区域选择性两步合成 1,3,5-三取代吡唑的两个连续串联过程。第一个是串联 MnO 2 介导的氧化/拉米雷斯烯化反应，为 β,β-二溴烯酮提供了一条简便的途径。然后，这些有价值的 1,3-二羰基合成子可以通过第二个串联肼缩合/Suzuki-Miyaura 交叉偶联反应转化为 1,3,5-三取代的吡唑。使用这些程序，一系列芳基和烷基 α-羟基酮已被区域选择性地转化为 1,3,5-三取代的吡唑。