N-(6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-1-methylpyrazole-4-sulfonamide | 851758-68-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-1-methylpyrazole-4-sulfonamide
• CAS: 851758-68-4
• 化学式: C₁₄H₁₅N₅O₂S
• 分子量: 317.371
• InChiKey: MEVYWHLCVRIWJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-1-methylpyrazole-4-sulfonamide 在 三乙基硅烷 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 N-[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-N,1-dimethylpyrazole-4-sulfonamide
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors

  摘要：

  Tetrahydroquinoline-based small molecule inhibitors of farnesyltransferase (FT) have been identified. Lead compounds were shown to have nanomolar to sub-nanomolar activity in biochemical assays with excellent potency in a Ras-mutated cellular reversion assay. BMS-316810 (9e), a 0.7 nM FT inhibitor, was orally-active in a nude mouse tumor allograft efficacy study. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.004
• 作为产物：
  描述：

  (6-Bromo-1,2,3,4-tetrahydro-3-quinolinyl)carbamic acid, 1,1-dimethylethyl ester 在 四(三苯基膦)钯 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 N-(6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)-1-methylpyrazole-4-sulfonamide
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors

  摘要：

  Tetrahydroquinoline-based small molecule inhibitors of farnesyltransferase (FT) have been identified. Lead compounds were shown to have nanomolar to sub-nanomolar activity in biochemical assays with excellent potency in a Ras-mutated cellular reversion assay. BMS-316810 (9e), a 0.7 nM FT inhibitor, was orally-active in a nude mouse tumor allograft efficacy study. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.004

文献信息

• Design, synthesis, and structure–activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors
  作者：Louis J. Lombardo、Amy Camuso、John Clark、Krista Fager、Johnni Gullo-Brown、John T. Hunt、Ivan Inigo、David Kan、Barry Koplowitz、Francis Lee、Kelly McGlinchey、Ligang Qian、Carolyn Ricca、George Rovnyak、Sarah Traeger、John Tokarski、David K. Williams、Laurence I. Wu、Yufen Zhao、Veeraswamy Manne、Rajeev S. Bhide

  DOI：10.1016/j.bmcl.2005.02.004

  日期：2005.4

  Tetrahydroquinoline-based small molecule inhibitors of farnesyltransferase (FT) have been identified. Lead compounds were shown to have nanomolar to sub-nanomolar activity in biochemical assays with excellent potency in a Ras-mutated cellular reversion assay. BMS-316810 (9e), a 0.7 nM FT inhibitor, was orally-active in a nude mouse tumor allograft efficacy study. (c) 2005 Elsevier Ltd. All rights reserved.