Q2FA12 | 887604-23-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Q2FA12
• 英文别名: 12-(2,5-dimethoxyphenyl)dodecan-1-ol
• CAS: 887604-23-1
• 化学式: C₂₀H₃₄O₃
• 分子量: 322.488
• InChiKey: BWXIPYIQFJTWDC-UHFFFAOYSA-N

物化性质

• 沸点：
  439.7±25.0 °C(Predicted)
• 密度：
  0.968±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Q2FA12 在 三溴化硼 、 水 作用下， 以 二氯甲烷 、 乙醚 为溶剂， 反应 1.0h， 以95%的产率得到2-(12-hydroxydodecyl)benzene-1,4-diol
  参考文献：
  名称：

  EP1854777

  摘要：

  公开号：
• 作为产物：
  描述：

  1,10-癸二醇 在 palladium on activated charcoal 哌啶 、 四(三苯基膦)钯 、 氢溴酸 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 、 环己烷 、 二甲基亚砜 为溶剂， 反应 54.5h， 生成 Q2FA12
  参考文献：
  名称：

  Quinol fatty alcohols as promoters of axonal growth

  摘要：

  The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2,5-dimethoxyphenyl)pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n=15), shows the most potent promotion of axonal growth in the presence of both permissive and non-permissive naturally occurring substrates such as Sema3A and myelin proteins. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.041

文献信息

• Hydroquinone Long-Chain Derivative and/or Phenoxy Long-Chain Derivative and Pharmaceutical Comprising Same
  申请人：Luu Bang

  公开号：US20090036542A1

  公开（公告）日：2009-02-05

  The present invention provides compounds represented by formula (1) shown below: (wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R 6 , R 7 , R 8 , R 9 , and R 10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group). The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供以下式子（1）所示的化合物：（其中R1、R2、R3、R4和R5分别从氢原子、甲基基团、乙酰基团、羟基团和烷氧基中各自选择；X代表烷基或烯基）；以及以下式子（2）所示的化合物：（其中R6、R7、R8、R9和R10分别从氢原子、烷基、乙酰基团、羟基团和烷氧基中各自选择；A代表氧原子或NH，m为0或1；Y代表烷基或烯基，Z代表氢原子或羟基）。本发明的化合物对于预防或治疗由中枢神经系统或外周神经系统细胞的退化和/或丧失引起的脑功能障碍、运动功能障碍或尿功能障碍是有用的。
• Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals comprising the same
  申请人：Meiji Dairies Corporation

  公开号：US07893304B2

  公开（公告）日：2011-02-22

  The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供了化合物，用于预防或治疗由中枢神经系统或外周神经系统细胞的退化和/或丢失引起的脑功能障碍、运动功能障碍或泌尿功能障碍。
• HYDROQUINONE LONG-CHAIN DERIVATIVE AND/OR PHENOXY LONG-CHAIN DERIVATIVE, AND PHARMACEUTICAL PREPARATION COMPRISING THE SAME
  申请人：Meiji Dairies Corporation

  公开号：EP1854777A1

  公开（公告）日：2007-11-14

  The present invention provides compounds represented by formula (1) shown below: (wherein R1, R2, R3, R4, and R5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R6, R7, R8, R9, and R10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group). The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供了由下式（1）代表的化合物： (其中 R1、R2、R3、R4 和 R5 各自单独选自氢原子、甲基、乙酰基、羟基和烷氧基；X 代表亚烷基或烯基）；以及 下式（2）所代表的化合物： (其中 R6、R7、R8、R9 和 R10 各自单独选自氢原子、烷基、乙酰基、羟基和烷氧基；A 代表氧原子或 NH，m 为 0 或 1；Y 代表亚烷基或烯基，Z 代表氢原子或羟基）。 本发明的化合物可用于预防或治疗由中枢神经系统或周围神经系统细胞变性和/或丧失引起的大脑功能障碍、运动功能障碍或泌尿系统功能障碍。
• Long-chain trimethoxyphenylalkanol derivatives, and pharmaceuticals comprising the same
  申请人：Meiji Co., Ltd.

  公开号：EP2418191A1

  公开（公告）日：2012-02-15

  The present invention provides compounds of the following formula (2), a pharmaceutically acceptable salt thereof, or a solvate or hydrate thereof: wherein Y is an alkylene group with 10 to 20 carbons The compounds of the present invention are useful as antioxidants.

  本发明提供下式（2）化合物、其药学上可接受的盐或其溶液或水合物： 其中 Y 是含 10 至 20 个碳原子的亚烷基 本发明的化合物可用作抗氧化剂。
• US7893304B2
  申请人：——

  公开号：US7893304B2

  公开（公告）日：2011-02-22