5,5'-oxybis(pentan-1-ol) | 14774-42-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,5'-oxybis(pentan-1-ol)
• 英文别名: 5-(5-Hydroxypentoxy)pentan-1-ol
• CAS: 14774-42-6
• 化学式: C₁₀H₂₂O₃
• mdl: MFCD08437461
• 分子量: 190.283
• InChiKey: LUUGAJBKZCJNFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5'-oxybis(pentan-1-ol) 在 过碘酸 、 pyridinium chlorochromate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 生成 6-氧杂-十一烷二酸
  参考文献：
  名称：

  DEZOCINE ANALOGUE

  摘要：

  公开号：

  EP3401306B1
• 作为产物：
  描述：

  6-氧杂-十一烷二酸 在 乙醇 、 sodium 作用下， 生成 5,5'-oxybis(pentan-1-ol)
  参考文献：
  名称：

  Alexander; Schniepp, Journal of the American Chemical Society, 1948, vol. 70, p. 1842

  摘要：

  DOI：

文献信息

• Highly Efficient Synthesis of Monodisperse Poly(ethylene glycols) and Derivatives through Macrocyclization of Oligo(ethylene glycols)
  作者：Hua Zhang、Xuefei Li、Qiuyan Shi、Yu Li、Guiquan Xia、Long Chen、Zhigang Yang、Zhong-Xing Jiang

  DOI：10.1002/anie.201410309

  日期：2015.3.16

  A macrocyclic sulfate (MCS)‐based approach to monodisperse poly(ethylene glycols) (M‐PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62‐membered macrocycle) as versatile precursors for a range of monofunctionalized M‐PEGs. Through iterative nucleophilic ring‐opening reactions of MCS without performing group

  已开发出一种基于大环硫酸盐（MCS）的单分散聚乙二醇（M-PEG）及其单官能化衍生物的方法。寡聚乙二醇（OEG）的大环化提供了MCS（最多62个成员的大环），作为一系列单官能化M-PEG的通用前体。通过MCS的反复亲核开环反应而无需进行基团保护和激活，可以轻松制备一系列M-PEG，包括史无前例的64-mer（2850 Da）。合成简单性与这种新策略的多功能性可能为M-PEG的更广泛应用铺平道路。
• Continuous-Flow Multistep Synthesis of Cinnarizine, Cyclizine, and a Buclizine Derivative from Bulk Alcohols
  作者：Svetlana Borukhova、Timothy Noël、Volker Hessel

  DOI：10.1002/cssc.201501367

  日期：2016.1

  Cinnarizine, cyclizine, buclizine, and meclizine belong to a family of antihistamines that resemble each other in terms of a 1‐diphenylmethylpiperazine moiety. We present the development of a four‐step continuous process to generate the final antihistamines from bulk alcohols as the starting compounds. HCl is used to synthesize the intermediate chlorides in a short reaction time and excellent yields

  肉桂利嗪，环利嗪，丁克利嗪和甲氯嗪属于抗组胺药家族，它们在1-二苯基甲基哌嗪部分上彼此相似。我们提出了一个四步连续过程的开发过程，该过程从大量的醇类作为起始化合物生成最终的抗组胺药。HCl用于在短的反应时间内合成中间氯化物，并具有优异的收率。该方法学提供了合成用于药物合成的中间体的绝佳方法。在线分离允许在以下步骤中收集纯净的产品并立即消费它们。肉桂利嗪，环齐嗪和丁克利嗪衍生物的总分离产率分别为82％，94％和87％。这四个步骤的总停留时间为90分钟，生产率为2 mmol h -1。
• FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
  申请人：ESPERVITA THERAPEUTICS, INC.

  公开号：US20210024447A1

  公开（公告）日：2021-01-28

  This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

  这项发明提供了Formulae（IA）、（IB）、（IC）、（ID）、（IE）、（IF）、（IG）、（IH）、（IJ）、（IK）、（IL）、（II）、（III）、（IIIA）和（IIIB）的化合物；这些化合物的药学上可接受的盐和溶剂；以及它们的组合物。这项发明还提供了治疗疾病的方法，包括但不限于肝病或异常肝脏状况；癌症（如肝细胞癌或胆管癌）；肺、肝、胆囊、胆管或消化道的恶性或良性肿瘤；肝内或肝外胆管疾病；脂蛋白紊乱；脂质和代谢紊乱；肝硬化；纤维化；葡萄糖代谢紊乱；心血管或相关血管紊乱；由脂肪变性、纤维化或肝硬化引起的疾病；与炎症增加有关的疾病（如肝炎或肺炎炎症）；肝细胞球形变；过氧化物酶体增殖子激活受体相关的疾病；ATP柠檬酸裂合酶疾病；乙酰辅酶A羧化酶疾病；肥胖；胰腺炎；或肾脏疾病。
• MANUFACTURING METHOD FOR POLYCARBONATE
  申请人：——

  公开号：US20020037838A1

  公开（公告）日：2002-03-28

  A method for manufacturing polycarbonate by melt-polycondensing bisphenol and carbonic acid diester uses as catalyst an alkali metal compound and/or alkaline earth metal compound (a). The catalyst is added to the bisphenol prior to the melt polycondensation, in an effective amount, i.e., the amount of alkali metal compound and/or alkaline earth metal compound (a) that acts effectively as a catalyst, is contained in said bisphenol, and is controlled to have the same catalytic activity as 1×10 −8 to 1×10 −6 mole of bisphenol disodium salt per mole of pure bisphenol A. The method conducts the reaction efficiently from the initial stage in a stable manner to obtain polycarbonate with good color, good heat stability and color stability during molding and the like.

  一种通过熔融缩聚双酚和碳酸二酯制造聚碳酸酯的方法，使用碱金属化合物和/或碱土金属化合物（a）作为催化剂。催化剂在熔融缩聚之前被添加到双酚中，添加的量是有效的，即碱金属化合物和/或碱土金属化合物（a）的量作为催化剂是包含在双酚中的，并且被控制为具有与1×10^-8至1×10^-6摩尔双酚二钠盐相同的催化活性。该方法从初始阶段开始有效地进行反应，稳定地获得具有良好颜色、良好热稳定性和成型过程中颜色稳定性的聚碳酸酯。
• COMPOSITIONS AND METHOD FOR MAKING THEREOF
  申请人：Davis Gary Charles

  公开号：US20100010262A1

  公开（公告）日：2010-01-14

  A composition has a structure as shown in formula I: R 1 and R 2 are independently at each occurrence an aliphatic radical having from 1 to about 10 carbons, a cycloaliphatic radical having from about 3 to about 10 carbons, or an aromatic radical having from about 3 to about 12 carbons; R 3 , R 4 , and R 5 are independently at each occurrence a hydrogen atom, an aliphatic radical having from 1 to about 10 carbons, a cycloaliphatic radical having from about 3 to about 10 carbons, or an aromatic radical having from about 3 to about 12 carbons; R 6 and R 7 are independently at each occurrence a hydrogen atom or an aliphatic radical having from 1 to about 6 carbons; X is a halogen; and “n” is an integer having a value of from 0 to about 4.

  一种化合物具有如公式I所示的结构：R1和R2在每次出现时独立地为具有1到约10个碳的脂肪基，约3到约10个碳的环脂肪基或约3到约12个碳的芳香基；R3、R4和R5在每次出现时独立地为氢原子，具有1到约10个碳的脂肪基，约3到约10个碳的环脂肪基或约3到约12个碳的芳香基；R6和R7在每次出现时独立地为氢原子或具有1到约6个碳的脂肪基；X是卤素；“n”是一个整数，其值从0到约4。