2-(2-chloro-acetylamino)-2-deoxy-D-glucose | 59817-28-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-chloro-acetylamino)-2-deoxy-D-glucose
• 英文别名: Chloressigsaeure-D-glucose-2-ylamid；2-(2-Chlor-acetylamino)-2-desoxy-D-glucose；Glucose, 2-deoxy-2-(chloroacetamido)-, D-；2-chloro-N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]acetamide
• CAS: 59817-28-6
• 化学式: C₈H₁₄ClNO₆
• 分子量: 255.655
• InChiKey: IUJFUANKDINYAJ-LRSZDJBLSA-N

物化性质

• 沸点：
  689.9±55.0 °C(Predicted)
• 密度：
  1.533±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  D-氨基葡萄糖盐酸盐 、 氯乙酰氯 在 sodium hydroxide 作用下， 生成 2-(2-chloro-acetylamino)-2-deoxy-D-glucose
  参考文献：
  名称：

  Bertho et al., Justus Liebigs Annalen der Chemie, 1931, vol. 485, p. 127,135,145

  摘要：

  DOI：

文献信息

• INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME
  申请人：Children's Hospital & Research Center at Oakland

  公开号：EP2173166A1

  公开（公告）日：2010-04-14
• US8999954B2
  申请人：——

  公开号：US8999954B2

  公开（公告）日：2015-04-07
• [EN] INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME<br/>[FR] INHIBITEURS DE L'ACIDE POLYSIALIQUE DE-N-ACÉTYLASE ET PROCÉDÉS POUR LEUR UTILISATION
  申请人：CHILDRENS HOSP & RES CT OAK

  公开号：WO2009006591A1

  公开（公告）日：2009-01-08

  The invention relates to inhibitors of polysialic (PSA) de-N-acetylase, methods of their production and use. The methods involve use of a PSA de-N-acetylase inhibitor for modifying the growth of cells, such as inhibiting the growth of cancer cells. The compositions include an inhibitor of a PSA de-N-acetylase, such as N-substituted derivatives of the amino sugars hexosamine and neuraminic acid, as well as conjugates and aggregates. Also provided are pharmaceutical compositions that include a PSA de-N-acetylase inhibitor of the invention. Kits containing one or more inhibitor compositions of the invention, as well as methods of preparing the compositions also are provided.