3-diazo-1-(3,6,7,8-tetrahydro-1H-cyclopenta[e][2]benzofuran-7-yl)butan-2-one | 1207535-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 3-diazo-1-(3,6,7,8-tetrahydro-1H-cyclopenta[e][2]benzofuran-7-yl)butan-2-one
• CAS: 1207535-82-7
• 化学式: C₁₅H₁₆N₂O₂
• 分子量: 256.304
• InChiKey: LPYVVHXAOJCZTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  28.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-diazo-1-(3,6,7,8-tetrahydro-1H-cyclopenta[e][2]benzofuran-7-yl)butan-2-one 在 copper acetylacetonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.0h， 以7%的产率得到
  参考文献：
  名称：

  Rapid Assembly of the Salvileucalin B Norcaradiene Core

  摘要：

  Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.

  DOI：

  10.1021/ol902848k
• 作为产物：
  描述：

  重氮乙烷 、 以 四氢呋喃 、 乙醚 为溶剂， 反应 12.0h， 以70 mg的产率得到3-diazo-1-(3,6,7,8-tetrahydro-1H-cyclopenta[e][2]benzofuran-7-yl)butan-2-one
  参考文献：
  名称：

  Rapid Assembly of the Salvileucalin B Norcaradiene Core

  摘要：

  Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.

  DOI：

  10.1021/ol902848k

文献信息

• Rapid Assembly of the Salvileucalin B Norcaradiene Core
  作者：Sergiy Levin、Roger R. Nani、Sarah E. Reisman

  DOI：10.1021/ol902848k

  日期：2010.2.19

  Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.