(2S,3R,4S,6R)-4-(dimethylamino)-2-((1R,3R,6R,8R,9R,10R,12R,13S,17S)-3-ethyl-10-methoxy-6,8,10,12,15,15,17-heptamethyl-2-methylene-5,7-dioxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yloxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate | 1261067-65-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,6R)-4-(dimethylamino)-2-((1R,3R,6R,8R,9R,10R,12R,13S,17S)-3-ethyl-10-methoxy-6,8,10,12,15,15,17-heptamethyl-2-methylene-5,7-dioxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yloxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate
• 英文别名: [(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(1R,3R,6R,8R,9R,10R,12R,13S,17S)-3-ethyl-10-methoxy-6,8,10,12,15,15,17-heptamethyl-2-methylidene-5,7-dioxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yl]oxy]-6-methyloxan-3-yl] benzoate
• CAS: 1261067-65-5
• 化学式: C₄₀H₆₁NO₁₀
• 分子量: 715.925
• InChiKey: LSBRGRSOJURYQT-UAQITHCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  51
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  (2S,3R,4S,6R)-4-(dimethylamino)-2-((1R,3R,6R,8R,9R,10R,12R,13S,17S)-3-ethyl-10-methoxy-6,8,10,12,15,15,17-heptamethyl-2-methylene-5,7-dioxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yloxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate 、 重氮乙酸甲酯 以 1,2-二氯乙烷 为溶剂， 反应 25.0h， 以69.7%的产率得到(1R,3R,6R,8R,9R,10R,12R,13S,17S)-methyl-9-((2S,3R,4S,6R)-3-(benzoyloxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yloxy)-3-ethyl-10-methoxy-6,8,10,12,15,15,17-heptamethyl-5,7-dioxo-3',5'-dihydro-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-2,4'-pyrazole]-3'-carboxylate
  参考文献：
  名称：

  Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

  摘要：

  A series of C-12 pyrazolinyl Spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-bacterial activities against both erythromycin-susceptible and erythromycin-resistant bacteria were reported. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.09.060
• 作为产物：
  描述：

  (2S,3R,4S,6R)-4-(dimethylamino)-2-((1R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ethyl-7-hydroxy-10-methoxy-6,8,10,12,15,15,17-heptamethyl-2-methylene-5-oxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yloxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以95.6%的产率得到(2S,3R,4S,6R)-4-(dimethylamino)-2-((1R,3R,6R,8R,9R,10R,12R,13S,17S)-3-ethyl-10-methoxy-6,8,10,12,15,15,17-heptamethyl-2-methylene-5,7-dioxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yloxy)-6-methyltetrahydro-2H-pyran-3-yl benzoate
  参考文献：
  名称：

  Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

  摘要：

  A series of C-12 pyrazolinyl Spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-bacterial activities against both erythromycin-susceptible and erythromycin-resistant bacteria were reported. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.09.060

文献信息

• Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides
  作者：Lei Hu、Ping Lan、Qiu-Ling Song、Zhi-Jian Huang、Ping-Hua Sun、Chao Zhuo、Ying Wang、Shunian Xiao、Wei-Min Chen

  DOI：10.1016/j.ejmech.2010.09.060

  日期：2010.12

  A series of C-12 pyrazolinyl Spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-bacterial activities against both erythromycin-susceptible and erythromycin-resistant bacteria were reported. (C) 2010 Elsevier Masson SAS. All rights reserved.