N-tetradecanoyl-DL-α-alanine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tetradecanoyl-DL-α-alanine
• 英文别名: N-myristoyl alanine；N-Myristoylalanine；2-(tetradecanoylamino)propanoic Acid
• 化学式: C₁₇H₃₃NO₃
• 分子量: 299.454
• InChiKey: XDOBXTLSTUFRRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  胆固醇 、 N-tetradecanoyl-DL-α-alanine 在 对甲苯磺酸 sodium hydroxide 作用下， 以 氮气 、 丙酮 、 甲苯 为溶剂， 生成 N-myristoylalanine cholesteryl ester
  参考文献：
  名称：

  Oily material composition

  摘要：

  本公开了一种油性材料组合物，其作为有效成分包括特定的N-长链酰基中性氨基酸的烷基或烯基酯和特定的N-长链酰基中性氨基酸的固醇酯，或者除了上述两种酯之外还包括一种两性物质，该组合物具有良好的保湿性能和良好的透湿性能，以及良好的吸水性能和良好的乳化稳定性，并在使用时表现出良好的手感（即不粘腻、良好的兼容性、无沉重感和良好的延展性），并且在化妆品组合物或皮肤外用剂组合物中加入时，具有赋予保湿性能和透湿性能以及乳化稳定性的优点，并在使用时具有良好的手感。

  公开号：

  US06447790B1
• 作为产物：
  描述：

  DL-丙氨酸钠盐 、 肉豆蔻酰氯 以 水 为溶剂， 反应 1.0h， 生成 N-tetradecanoyl-DL-α-alanine
  参考文献：
  名称：

  Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R., Journal of the Indian Chemical Society, 1982, vol. 59, # 7, p. 856 - 859

  摘要：

  DOI：

文献信息

• [EN] HUMAN MICROBIOTA DERIVED N-ACYL AMIDES FOR THE TREATMENT OF HUMAN DISEASE<br/>[FR] N-ACYL AMIDES DÉRIVÉS DU MICROBIOTE HUMAIN POUR LE TRAITEMENT D'UNE MALADIE HUMAINE
  申请人：UNIV ROCKEFELLER

  公开号：WO2019006246A1

  公开（公告）日：2019-01-03

  The present invention provides compositions and methods for the modulation of G protein-coupled receptors (GPCRs). The invention provides a genetically engineered cell, wherein the cell expresses a human microbial N-acyl synthase (hm-NAS) gene. In one embodiment, the hm-NAS gene is N-acyl serinol synthase. The invention provides a probiotic composition, the probiotic composition comprises a genetically engineered cell of the invention. The invention provides a method for modulating a G protein-coupled receptor (GPCR) activity in a subject, the method comprises administering to the subject an effective amount of a composition comprising at least one selected from the group consisting of a genetically engineered cell, an hm-NAS gene, and a N-acyl amide.

  本发明提供了用于调节G蛋白偶联受体（GPCRs）的组合物和方法。该发明提供了一种基因工程细胞，其中该细胞表达人类微生物N-酰基合酶（hm-NAS）基因。在一个实施例中，hm-NAS基因是N-酰丝氨醇合酶。该发明提供了一种益生菌组合物，该益生菌组合物包括该发明的基因工程细胞。该发明提供了一种调节受体内G蛋白偶联受体（GPCR）活性的方法，该方法包括向受体施用包含至少选自基因工程细胞、hm-NAS基因和N-酰胺的组合物的有效量。
• [EN] PRODUCTS AND METHODS FOR THE TREATMENT OF MIXTURES OF WATER AND HYDROPHOBIC LIQUIDS<br/>[FR] PRODUITS ET PROCÉDÉS POUR LE TRAITEMENT DE MÉLANGES D'EAU ET DE LIQUIDES HYDROPHOBES
  申请人：B C RES INC

  公开号：WO2019232629A1

  公开（公告）日：2019-12-12

  Chemical-based methods and products for mitigating the impact of an oil spill are disclosed. The products act by herding, thickening, gelling, and reducing adhesiveness. N-fatty acid amino acid (FA-AA) conjugates display oil-herding behavior when formulated as a free acid in water-miscible organic solvents. A water-miscible organic solvent is not required if the FA-AA conjugate is formulated as a salt. Various salts of FA-AA conjugates are water soluble and can herd oils and increase the thickness of the oil layer. Replacement of the acid group of fatty acid α-amino acid conjugates with other groups that act as hydrogen bond donors and acceptors results in potent phase selective organo-gellants. The oil spill herders can be prepared from bio-based feedstocks and are biodegradable. The oil thickeners or gellants, which are prepared from bio-based feedstocks, have low toxicity, high capacity for oil and reduce the need to use an organic solvent to apply the thickener or gellant to the oil and water mixture in order to gel the oil phase. Formulae (IB), (II), (III)

  本发明涉及化学方法和产品，用于减轻油污泄漏的影响。这些产品通过聚集、增稠、胶化和降低粘性来发挥作用。当N-脂肪酸氨基酸（FA-AA）共轭物被制成水溶性有机溶剂中的自由酸时，它们具有聚集油的行为。如果FA-AA共轭物被制成盐，则不需要水溶性有机溶剂。各种FA-AA共轭物的盐是水溶性的，可以聚集油并增加油层的厚度。将脂肪酸α-氨基酸共轭物的酸基替换为其他作为氢键供体和受体的基团，可以得到有效的相选择性有机胶凝剂。这些油污聚集剂可以从生物基原料制备，并且是可生物降解的。从生物基原料制备的油稠剂或胶凝剂具有低毒性，对油具有高容量，并且减少了使用有机溶剂将稠剂或胶凝剂应用于油水混合物以胶化油相的需要。公式（IB）、（II）、（III）。
• GRANULAR SURFACTANT AND PROCESS FOR PRODUCING THE SAME
  申请人：Ajinomoto Co., Inc.

  公开号：EP1340806A1

  公开（公告）日：2003-09-03

  A granular surfactant which is obtained, for example, by simultaneous granulation and drying by spraying a solution or slurry, in which a whole or a part of a surfactant is dissolved or dispersed in water or warm water, in a fluidized bed where hot air is introduced, and then by classification of the granules obtained in the above step to remove granules having lower diameters. Typically, a weight ratio of granules having a diameter of 0.1 mm or less is 2.0 wt % or less and a median diameter is 0.17 mm or more. The granular surfactants are easily manufactured and have high water solubility, reduced powder dust, and fluidities.

  一种颗粒状表面活性剂，例如，通过将溶液或浆料（其中全部或部分表面活性剂溶解或分散在水中或温水中）喷洒在导入热空气的流化床中，同时进行造粒和干燥，然后对上述步骤中获得的颗粒进行分级，以去除直径较小的颗粒，从而获得颗粒状表面活性剂。通常情况下，直径为 0.1 毫米或以下的颗粒的重量比为 2.0 重量百分比或以下，中值直径为 0.17 毫米或以上。颗粒表面活性剂易于制造，水溶性高，粉尘少，流动性好。
• Acrylic polymer composition for cosmetics
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP1486514A1

  公开（公告）日：2004-12-15

  The invention provides a resin for cosmetics with superior transparency that yields excellent balance between properties such as water resistance, adhesion, lasting effect and pulling feel. The resin for cosmetics is a resin for cosmetics obtained by emulsion polymerization of a monomer mixture containing: (A): at least one selected from the group consisting of acrylic acid, methacrylic acid, maleic acid, itaconic acid and crotonic acid, (B): at least one selected from the group consisting of alkyl(meth)acrylate monomers having an alkyl group with a carbon number of 1 to 4, and (C): at least one selected from the group consisting of alkyl(meth)acrylate monomers having an alkyl group with a carbon number of 5 or more, wherein the monomer mixture contains 10 to 20 parts by weight of the (A), 40 to 80 parts by weight of the (B) and 10 to 40 parts by weight of the (C), based upon the total of the (A) to (C) taken as 100 parts by weight.

  本发明提供了一种透明性极佳的化妆品用树脂，可在耐水性、粘附性、持久效果和拉扯感等特性之间取得极佳的平衡。该化妆品用树脂是通过乳液聚合单体混合物获得的化妆品用树脂，该单体混合物包含：(A)：至少一种选自丙烯酸、甲基丙烯酸、马来酸、衣康酸和巴豆酸的单体；(B)：至少一种选自具有碳原子数为 1 至 4 的烷基的烷基（甲基）丙烯酸酯单体；以及(C)：从具有碳数为 5 或更多烷基的烷基（甲基）丙烯酸酯单体组成的组中选出的至少一种单体，其中单体混合物含有 10 至 20 份（按重量计）(A)、40 至 80 份（按重量计）(B)和 10 至 40 份（按重量计）(C)，以(A)至(C)的总和为 100 份（按重量计）为基准。
• CLEANING COMPOSITION
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3470505A1

  公开（公告）日：2019-04-17

  There is provided a cleaning composition having good foamability and being capable of producing fine and stable foams with resilient texture. More specifically, there is provided a cleaning composition comprising a surfactant, methyl cellulose, hydroxypropyl methyl cellulose, and a solvent.

  本发明提供了一种清洁组合物，该组合物具有良好的发泡性，能够产生细腻稳定且质地有弹性的泡沫。更具体地说，本发明提供了一种清洁组合物，其中包括表面活性剂、甲基纤维素、羟丙基甲基纤维素和溶剂。