The present invention provides compositions containing a mixture of cholesterol sulfate and an exfoliant. The exfoliant can be N-acetyl-D-glucosamine, N-acetylgalactosamine, or a combination thereof. The combination of the cholesterol sulfate with the exfoliant surprisingly enhances the skin barrier even though the activity of each of the components is opposite the other. In addition, because of the ability to enhance or repair the skin barrier function, methods of improving or maintaining a healthy skin barrier are included in the present invention by applying to the skin an effective amount of the mixture of cholesterol sulfate with the exfoliant. The mixture can also be useful in treating or preventing damage to the skin, where the damage is caused by a compromised skin barrier function. As a result of improving the skin barrier function with the combination of cholesterol sulfate and the exfoliant, the appearance of lines and wrinkles is generally reduced; rough and dry skin conditions are also improved.
本发明提供了含有
硫酸胆固醇和去角质剂混合物的组合物。去角质剂可以是
N-乙酰-D-葡糖胺、N-乙酰半
乳糖胺或它们的组合。
胆固醇硫酸盐与去角质剂的组合能出人意料地增强皮肤屏障,即使每种成分的活性是相反的。此外,由于本发明具有增强或修复皮肤屏障功能的能力,因此本发明还包括通过在皮肤上涂抹有效量的
胆固醇硫酸盐与去角质剂混合物来改善或维持健康皮肤屏障的方法。该混合物还可用于治疗或预防皮肤损伤,其中皮肤损伤是由受损的皮肤屏障功能引起的。使用
胆固醇硫酸盐和去角质剂的混合物改善皮肤屏障功能后,细纹和皱纹通常会减少,皮肤粗糙和干燥的状况也会得到改善。