dichloropropylphosphine | 15573-31-6

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 有机磷化合物 - 烷基卤代膦
• 英文名称: dichloropropylphosphine
• 英文别名: dichloro-n-propyl phosphine；n-Propyldichlorophosphine；dichloro(propyl)phosphane
• CAS: 15573-31-6
• 化学式: C₃H₇Cl₂P
• mdl: MFCD00013618
• 分子量: 144.968
• InChiKey: PVTHAGJZMANMRT-UHFFFAOYSA-N

物化性质

• 熔点：
  135-136℃
• 沸点：
  128°C
• 密度：
  1,118 g/cm3
• 稳定性/保质期：
  在常温常压下稳定，应避免接触水分、潮湿和氧化物以及碱类物质。

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 危险等级：
  8
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R14,R34
• 危险品运输编号：
  UN 3129
• 包装等级：
  II
• 危险类别：
  8
• 储存条件：
  常温下应密闭避光、存放在通风干燥且充满惰性气体的环境中。

SDS

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Section 1: Product Identification
Chemical Name: n-Propyldichlorophosphine, min. 98%
CAS Registry Number: 15573-31-6
Formula: n-C3H7PCl2
EINECS Number: none
Chemical Family: organophosphine halide
Synonym: Dichloropropylphosphine, Phosphine, dichloropropyl-

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 15573-31-6 100% no data no data

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Section 3: Hazards Identification
Material has a pungent odor. Inhalation of vapor may cause coughing, headache, and pulmonary edema. Very
Emergency Overview:
corrosive to eyes, skin, nose, and mucous membranes.
Primary Routes of Exposure: Contact with skin and eyes. Inhalation of vapor.
Eye Contact: Causes burns to the eyes.
Causes mild to severe irritation of the skin. Hydrochloric acid hydrolysis product is a corrosive liquid or vapor.
Skin Contact:
Inhalation: Corrosive Inhalation may cause spasms, coughing, chemical pneumonitis and pulmonary edema.
Ingestion: Corrosive to mouth throat and stomach. May cause dizziness, nausea, vomiting, pain and stomach upset.
Material has a pungent odor. Inhalation of vapor may cause chemical pneumonitis and pulmonary edema.
Acute Health Affects:
Contact of liquid or vapor with eyes and skin causes burns.
Chronic Health Affects: No information available on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide, dry powder or foam
If this material is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion and In a fire material may emit toxic organic fumes, carbon monoxide, carbon dioxide, and phosphorous pentoxide.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Small spills can be neutralized with powdered sodium bicarbonate, lime, or calcium carbonate and swept up.
Spill and Leak Procedures: Spillage in areas not adequately ventilated will require an evacuation of site. Emergency response teams will
require self-contained breathing apparatus.

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SECTION 7: Handling and Storage
Store in a cool, dry, well-ventilated area. Keep containers tightly sealed. Transfer material under an inert
Handling and Storage:
atmosphere of nitrogen or argon.

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SECTION 8: Exposure Controls and Personal Protection
Always wear safety glasses. If pouring or transferring this substance wear a face shield for additional
Eye Protection:
protection.
Skin Protection: Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation: Material has a pungent odor. Always handle material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Material has a pungent odor. Always handle material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: colorless liq.
Molecular Weight: 144.97
Melting Point: no data
Boiling Point: 133°C
Vapor Pressure: no data
Specific Gravity: 1.118
Odor: sharp acidic odor
Solubility in Water: Reacts vigorously with water

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SECTION 10: Stability and Reactivity
Stability: air sensitive, moisture sensitive
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: contact with air or moisture
Incompatibility: Water, air, oxidizing agents, active metals, oxygen and sulfur
Decomposition Products: carbon dioxide, carbon monoxide, phosphorus oxide, hydrogen chloride, and organic fumes

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SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Corrosive liquids, N.O.S.
Hazard Class (CFR): 8
Additional Hazard Class (CFR): NA
Packaging Group (CFR): I
UN ID Number (CFR): UN# 1760
Shipping Name (IATA): Corrosive liquid, N.O.S.
Hazard Class (IATA): 8
Additional Hazard Class (IATA): NA
Packaging Group (IATA): I
UN ID Number (IATA): UN# 1760

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SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  dichloropropylphosphine 在 水 作用下， 生成 丙基次膦酸
  参考文献：
  名称：

  Guichard, Chemische Berichte, 1899, vol. 32, p. 1574

  摘要：

  DOI：
• 作为产物：
  描述：

  二丙汞 在 三氯化磷 作用下， 生成 dichloropropylphosphine
  参考文献：
  名称：

  Guichard, Chemische Berichte, 1899, vol. 32, p. 1574

  摘要：

  DOI：

文献信息

• Substituted propane-phosphinic acid compounds
  申请人：Ciba-Geigy Corporation

  公开号：US05064819A1

  公开（公告）日：1991-11-12

  Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, or wherein R denotes methyl, R.sub.1 denotes hydrogen or hydroxy, R.sub.2 denotes an aromatic radical and R.sub.3 represents hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R.sup.6, or Z represents a protected or latent amino group Z.sup.0 and R.sup.4 denotes hydrogen or a hydroxy-protective group R.sup.5, any group R.sup.5 or R.sup.6 is replaced by hydrogen, and/or any group Z.sup.0 is converted into --NH.sub.2.

  公式I的化合物##STR1##其中R表示具有2个或更多碳原子的脂肪族、环脂族、环脂族-脂肪族或芳基脂肪基，其中R.sup.1、R.sup.2和R.sup.3中的一个代表氢或脂肪族、环脂族、芳基脂肪基或芳香族基，R.sup.1、R.sup.2和R.sup.3中的另一个是氢或在R.sup.1和R.sup.2的情况下是羟基，而R.sup.1、R.sup.2和R.sup.3中的剩余一个是氢，或者R表示甲基，R.sub.1表示氢或羟基，R.sub.2表示芳基，R.sub.3表示氢，它们的盐具有GABA.sub.B-拮抗性质，可用作GABA.sub.B-拮抗剂。当在公式II的化合物中获得它们##STR2##其中R、R.sup.1、R.sup.2和R.sup.3具有其先前的含义，Z表示--NH.sub.2，R.sup.4表示羟基保护基R.sup.5或者当R.sup.1和R.sup.3表示氢且R.sup.2表示氢或烷基时，表示碱金属或铵离子R.sup.6，或者Z表示受保护或潜在的氨基Z.sup.0且R.sup.4表示氢或羟基保护基R.sup.5，任何一个R.sup.5或R.sup.6基团被氢取代，和/或任何一个Z.sup.0基团被转化为--NH.sub.2。
• Synthesis, X-ray structures and chemistry of enantiomerically pure 10,11-dihydro-5-phenyl-5H-dibenzo[b,f  ]phosphepine 5-oxides
  作者：Paul Wyatt、Stuart Warren、Mary McPartlin、Tom Woodroffe

  DOI：10.1039/b006883g

  日期：——

  Several phosphepine oxides were synthesised in optically pure form. Sharpless asymmetric dihydroxylation was used to introduce the chiral centres in all cases. Ring closure was achieved using either PhPCl2 or PrPCl2 together with a double nucleophile generated by either a double ortho-lithiation or double bromine–lithium exchange. The X-ray crystal structures of three phosphepine oxides illustrate their different conformations. The NMR spectra of several phosphepine oxides are described as is the chemistry which is shown to differ from that of acyclic phosphine oxides.

  几种磷啶氧化物以光学纯度合成。所有情况下均使用Sharpless不对称二羟基化法引入手性中心。环的闭合是通过使用PhPCl₂或PrPCl₂以及由双正位锂化或双溴-锂交换生成的双亲核体来实现的。三种磷啶氧化物的X射线晶体结构展示了它们不同的构象。几种磷啶氧化物的核磁共振光谱被描述，其化学特性显示出与线性磷氧化物的不同。
• New modular P-chiral ligands for Rh-catalyzed asymmetric hydrogenation
  作者：Oleg G. Bondarev、Richard Goddard

  DOI：10.1016/j.tetlet.2006.10.122

  日期：2006.12

  New modular P-chiral ligands have been prepared from commercially available (S)-α,α-diphenylprolinol. With these new types of ligands, up to 95% ee was achieved in the Rh-catalyzed asymmetric hydrogenation of functionalized olefins.

  新的模块化P-手性配体已经由市售的（S）-α，α-二苯基脯氨醇制备。使用这些新型的配体，在Rh催化的官能化烯烃的不对称加氢反应中，ee达到了95％。
• Alkyl and aryl dicationic derivatives of cyclic triphosphenium ions
  作者：Keith B. Dillon、Andrés E. Goeta、Judith A. K. Howard、Philippa K. Monks、Helena J. Shepherd、Amber L. Thompson

  DOI：10.1039/b716027e

  日期：——

  Direct alkylation of cyclic triphosphenium ions by triflates to give di-ium dications is only possible for small organic substituents on the attacking reagent. The dicationic products are not intrinsically unstable, however, and in many instances they may be synthesised by an alternative route, pioneered by Schmidpeter and co-workers. These species may be readily identified in solution by (31)P NMR

  通过三氟甲磺酸酯将环状三离子直接烷基化以生成二碘盐，仅对于攻击试剂上的小的有机取代基而言是可能的。然而，这些药并不是本质上不稳定的，在许多情况下，它们可能是由Schmidpeter及其同事首创的另一种途径合成的。通过（31）P NMR光谱可以很容易地在溶液中鉴定出这些物质。通过120 K的单晶X射线衍射首次确定了五种此类衍生物的晶体和分子结构。与单阳离子母体环状三contrast相反，该结果证实了常规化合物中存在正常的单PP键长。离子，其中结构确定表明PP键的长度介于单键和双键之间。
• The relative stabilities of cyclic dicationic derivatives of diphosphanes with three (3P) or four (4P) linked phosphorus atoms
  作者：Rachel Bashforth、Alice J. Boyall、Philippa K. Coffer (née Monks)、Keith B. Dillon、Andrés E. Goeta、Judith A. K. Howard、Alan M. Kenwright、Michael R. Probert、Helena J. Shepherd、Amber L. Thompson

  DOI：10.1039/c1dt11549a

  日期：——

  or AlCl3 leads to the formation of dicationic heterocycles with three (3P) or four (4P) linked phosphorus atoms. Some 3P derivatives with small alkyl substituents may also be prepared by direct alkylation of cyclic triphosphenium ions. Several new species were prepared in solution, some of which were isolated and characterised by single-crystal X-ray diffraction. Investigations into the factors favouring

  在SnCl 2或AlCl 3的存在下，二膦与氯膦的反应导致形成带有三个（3P）或四个（4P）连接的磷原子的双阳离子杂环。一些具有小的烷基取代基的3P衍生物也可以通过环状三phosph离子的直接烷基化来制备。在溶液中制备了几种新物种，其中一些是通过单晶X射线衍射分离和表征的。描述了对有助于形成3P或4P物种的因素的研究。

表征谱图