4-[2-(3,3-Dimethylbicyclo[2.2.1]heptan-2-yl)ethyl]morpholine | 88100-38-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-[2-(3,3-Dimethylbicyclo[2.2.1]heptan-2-yl)ethyl]morpholine
• 英文别名: 4-[2-(3,3-dimethyl-2-bicyclo[2.2.1]heptanyl)ethyl]morpholine
• CAS: 88100-38-3
• 化学式: C₁₅H₂₇NO
• 分子量: 237.385
• InChiKey: JMNFBAHGYPAGPJ-UHFFFAOYSA-N

物化性质

• 沸点：
  311.2±17.0 °C(Predicted)
• 密度：
  0.965±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-[(2E)-2-(3,3-dimethyl-2-bicyclo[2.2.1]heptanylidene)ethyl]morpholine 生成 4-[2-(3,3-Dimethylbicyclo[2.2.1]heptan-2-yl)ethyl]morpholine
  参考文献：
  名称：

  KLEPEL, M.;FRANKE, F.;LEHMANN, H., J. ENVIRON. SCI. AND HEALTH, 1983, 18, N 4-5, 633-643

  摘要：

  DOI：

文献信息

• A Cooperative Rh/Co‐Catalyzed Hydroaminomethylation Reaction for the Synthesis of Terpene Amines
  作者：Alejandro Pérez Alonso、Doan Pham Minh、Daniel Pla、Montserrat Gómez

  DOI：10.1002/cctc.202300501

  日期：2023.7.7

  A novel metal-catalyzed strategy to facilitate the synthesis of terpene amines by a homogeneous pathway is reported. Combining the synergy between 3d and 4d transition metals with glycerol, acting as a boosting solvent, leads to an efficient and selective process for the four-component hydroaminomethylation reaction.

  报道了一种新的金属催化策略，通过均相途径促进萜胺的合成。将 3d 和 4d 过渡金属与甘油之间的协同作用相结合，作为增强溶剂，可实现四组分氢氨甲基化反应的高效和选择性过程。
• An efficient method for the transformation of naturally occurring monoterpenes into amines through rhodium-catalyzed hydroaminomethylation
  作者：Daniela S. Melo、Schubert S. Pereira-Júnior、Eduardo N. dos Santos

  DOI：10.1016/j.apcata.2011.10.021

  日期：2012.1

  The hydroaminomethylation (hydroformylation/reductive amination) of the naturally occurring monoterpenes, i.e., limonene, camphene, and beta-pinene, was studied having as condensation counterparts the amines di-n-butylamine, morpholine or n-butylamine. Moderate to good yields (75-94%) were obtained employing [Rh(cod)(mu-OMe)](2) as pre-catalyst in the presence or not of triphenylphosphine or tribenzylphosphine as ancillaries in toluene, at 100 degrees C and 60 bar of an equimolar mixture of carbon monoxide and hydrogen. Some of the hydroaminomethylation products derived from limonene have biological activity and the products derived from camphene and beta-pinene are new. (C) 2011 Elsevier BM. All rights reserved.