endo-N-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)benzamide | 101598-36-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: endo-N-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)benzamide
• 英文别名: Benzamide, N-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-；N-(1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)benzamide
• CAS: 101598-36-1
• 化学式: C₁₇H₂₃NO
• 分子量: 257.376
• InChiKey: NTWLHHBGBISWLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  endo-N-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)benzamide 在 五氯化磷 、 Petroleum ether 作用下， 生成 N-((1R)-bornyl)-N'-((1S)-bornyl)-benzamidine
  参考文献：
  名称：

  Cohen; Marshall, Journal of the Chemical Society, 1910, vol. 97, p. 330

  摘要：

  DOI：
• 作为产物：
  描述：

  樟脑 生成 endo-N-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)benzamide
  参考文献：
  名称：

  FOURNERON, J. -D.;ARCHELAS, A.;VIGNE, B.;FURSTOSS, R., TETRAHEDRON, 43,(1987) N 10, 2273-2284

  摘要：

  DOI：

文献信息

• Stereoretentive Copper(II)-Catalyzed Ritter Reactions of Secondary Cycloalkanols
  作者：Mohammed H. Al-huniti、Salvatore D. Lepore

  DOI：10.1002/adsc.201300233

  日期：2013.10.11

  A Ritter-like coupling reaction of cyclic alcohols and both aryl and alkyl nitriles to form amides catalyzed by copper (II) triflate is described. These reactions proceed in good yields under mild and often solvent-free conditions. With 2- and 3-substituted cycloalkanols, amide products are formed with near complete retention of configuration. This is likely due to fast nucleophilic capture of a non-planar

  描述了环状醇与芳基和烷基腈两者的Ritter-like偶联反应，形成了由三氟甲磺酸铜（II）催化形成的酰胺。这些反应在温和且通常无溶剂的条件下以高收率进行。与2-和3-取代的环烷醇一起，形成酰胺产物，几乎完全保留了构型。这可能是由于通过环超共轭稳定的非平面碳正离子（超高聚物）的快速亲核捕获。该新颖的催化循环的关键方面是亚硫酰氯原位活化醇底物以形成亚氯硫酸盐。
• Pharmaceutical use of substituted amides
  申请人：Andersen Sune Henrik

  公开号：US20060111366A1

  公开（公告）日：2006-05-25

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文介绍了使用取代酰胺来调节11β-羟化甾体脱氢酶1型（11βHSD1）的活性以及将这些化合物用作制药组合物的方法。还介绍了一类新型的取代酰胺，它们在治疗中的应用、包含这些化合物的制药组合物以及它们在药物制剂制造中的应用。这些化合物是11βHSD1的调节剂，更具体地说是抑制剂，可用于治疗、预防和/或预防一系列需要降低活性糖皮质激素细胞内浓度的医学疾病。
• Amide Derivatives and Pharmaceutical Use Thereof
  申请人：Andersen Henrik Sune

  公开号：US20090264414A1

  公开（公告）日：2009-10-22

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文描述了使用取代酰胺来调节11β-羟化类固醇脱氢酶1型（11βHSD1）活性以及这些化合物作为药物组分的用途。还描述了一类新型的取代酰胺，它们在治疗中的用途，包括含有这些化合物的药物组分以及它们在制造药物中的用途。这些化合物是调节剂，更具体地说是11βHSD1活性的抑制剂，可用于治疗、预防和/或预防一系列医学疾病，其中降低细胞内活性糖皮质激素的浓度是可取的。
• Combinations of an 11-beta-hydroxysteroid dehaydrogenase type 1 inhibitor and a glucocorticoid receptor agonist
  申请人：NOVO NORDISK A/S

  公开号：EP1854487A2

  公开（公告）日：2007-11-14

  Combination therapy comprising the administration of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist for treating some forms of cancer, diseases and disorders having inflammation as a component, and to minimize the side effects associated with glucorticoid receptor agonist therapy.

  由 11β- 羟类固醇脱氢酶 1 型抑制剂和糖皮质激素受体激动剂组成的联合疗法，用于治疗某些形式的癌症、以炎症为组成部分的疾病和失调，并最大限度地减少与糖皮质激素受体激动剂疗法相关的副作用。
• Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
  申请人：NOVO NORDISK A/S

  公开号：EP1862181A2

  公开（公告）日：2007-12-05

  Combination therapy comprising the administration of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent useful for treating, preventing and reducing the risk of developing insulin resistance, dyslipidemia, obesity, hypertension and other related diseases and disorders.

  由 11β- 羟类固醇脱氢酶 1 型抑制剂和降压药组成的联合疗法，可用于治疗、预防和降低胰岛素抵抗、血脂异常、肥胖、高血压及其他相关疾病和紊乱的发病风险。