3-Methylhex-3-en-1-yne | 62839-54-7

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 3-Methylhex-3-en-1-yne
• CAS: 62839-54-7
• 化学式: C₇H₁₀
• 分子量: 94.1564
• InChiKey: KYOGSVAQRNIVQL-UHFFFAOYSA-N

物化性质

• 沸点：
  93 °C
• 密度：
  0.7671 g/cm3(Temp: 18 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3-Methylhex-3-en-1-yne 、 异丁醛 、 苄胺 在 copper(l) chloride 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以80%的产率得到
  参考文献：
  名称：

  A³-Coupling Reaction as a Strategy Towards the Synthesis of Alkaloids

  摘要：

  A number of aldehydes, alkynols and benzylamines were submitted to A(3)-coupling reaction, under CuCl catalysis, giving strategically functionalized hydroxy-propargylamines. The procedure allows the use of alkyl as well as aryl aldehydes. Representative substrates were converted into five- and six-membered cyclic alkaloids by sequential one-pot N-debenzylation/triple bond reduction promoted by Pd, followed by a Mitsunobu-type cyclization.

  DOI：

  10.5935/0103-5053.20140223

文献信息

• A³-Coupling Reaction as a Strategy Towards the Synthesis of Alkaloids
  作者：Rafaela C. Carmona、Edison P. Wendler、George H. Sakae、João V. Comasseto、Alcindo A. Dos Santos

  DOI：10.5935/0103-5053.20140223

  日期：——

  A number of aldehydes, alkynols and benzylamines were submitted to A(3)-coupling reaction, under CuCl catalysis, giving strategically functionalized hydroxy-propargylamines. The procedure allows the use of alkyl as well as aryl aldehydes. Representative substrates were converted into five- and six-membered cyclic alkaloids by sequential one-pot N-debenzylation/triple bond reduction promoted by Pd, followed by a Mitsunobu-type cyclization.