2-(2-(4-chlorophenyl)hydrazono)-1,3-diphenylpropane-1,3-dione | 24743-60-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(2-(4-chlorophenyl)hydrazono)-1,3-diphenylpropane-1,3-dione
• 英文别名: (4-chlorophenylhydrazono)dibenzoylmethane；2-[(4-chlorophenyl)hydrazinylidene]-1,3-diphenylpropane-1,3-dione
• CAS: 24743-60-0
• 化学式: C₂₁H₁₅ClN₂O₂
• 分子量: 362.815
• InChiKey: QCVIMMOYRRKXAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  515.7±52.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.87
• 重原子数：
  26.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.53
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(2-(4-chlorophenyl)hydrazono)-1,3-diphenylpropane-1,3-dione 在 溴 、 sodium acetate 、 乙酸酐 、 溶剂黄146 作用下， 反应 16.5h， 生成 N'-(4-chloro-phenyl)-2-oxo-2-phenyl-acetohydrazonoyl bromide
  参考文献：
  名称：

  EP1935874

  摘要：

  公开号：
• 作为产物：
  描述：

  p-chlorobenzenediazonium chloride 、 二苯甲酰基甲烷 在 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 2-(2-(4-chlorophenyl)hydrazono)-1,3-diphenylpropane-1,3-dione
  参考文献：
  名称：

  Elgemeie, Galal E. H.; Alnaimi, Ibrahim S.; Alarab, Hafsa F., Heterocycles, 1992, vol. 34, # 9, p. 1721 - 1728

  摘要：

  DOI：

文献信息

• Cyclization of Chlorosulfonyl Isocyanate with Phenylhydrazones: A Synthetic Route to Triazinonoxathiazinedioxides and Triazinones
  作者：Joseph Daniel、D. N. Dhar

  DOI：10.1080/00397919108021070

  日期：1991.8

  Abstract A convenient synthetic route is reported for the preparation of aroyl substituted triazinones and triazinono-xathiazinedioxides by the interaction of chlorosulfonyl isocyanate and phenylhydrazones (derived from acetylacetone, 1-benzoylacetone and dibenzoylmethane).

  摘要 报道了通过氯磺酰基异氰酸酯和苯腙（衍生自乙酰丙酮、1-苯甲酰丙酮和二苯甲酰甲烷）的相互作用制备芳酰基取代的三嗪酮和三嗪基-噻嗪二氧化物的便捷合成路线。
• Laser flash photolysis of aromatic azo-hydrazone systems
  作者：James McVie、Alastair D. Mitchell、Roy S. Sinclair、T. George Truscott

  DOI：10.1039/p29800000286

  日期：——

  Laser flash photolysis using 347 nm excitation and pulse radiolysis have been used to study the transient species produced from solutions of a series of eight hydrazone compounds synthesised from substituted (R1,R2) 1,3-diones coupled to substituted (Ar) aromatic amines. Three classes of transient behaviour were found in hexane solution. Compound (8) gave a very short-lived transient (t½ca. 45 ns,

  使用347 nm激发和脉冲辐射分解的激光闪光光解已用于研究由取代的（R 1，R 2）1,3-二酮与取代的（Ar）芳族化合物合成的一系列八化合物的溶液产生的瞬态物种胺类。在己烷溶液中发现了三类瞬态行为。化合物（8），得到一个非常短暂的瞬态（吨½约45纳秒，λ最大510nm处），其被鉴定为物种三重。从不对称二酮衍生物其他三种化合物对短暂瞬变（吨½约50-100微秒）的光谱区440-460纳米和长寿命的瞬变（吨½约。0.5–2.0 s）发生在大约 425 nm，而四个对称导数（R 1 = R 2）仅给出了450-470 nm区域中的短暂瞬变。寿命更长的瞬变的寿命显示出取决于溶剂极性和添加的酸。提出寿命更长的瞬态与由光激发成单线态激发态引起的关于C N键的异构有关。确定了用三种hydr酮淬灭各种三线态物质的速率常数，并显示出与被淬灭化合物的三线态能量相关的速率常数。假设通过电子能量转移发生猝灭，估计hydr的三重态能量在150-190
• Pyridine‐Catalysed Desulfonylative Addition of β‐Diketones to Arylazosulfones via Diaziridine Rearrangement
  作者：Xin Ji、Ling‐Guo Meng、Hailong Xu、Lei Wang

  DOI：10.1002/adsc.202001171

  日期：2021.2.16

  pyridine‐catalysed desulfonylative addition of β‐diketones to arylazosulfones was developed to obtain diazenyl β‐dicarbonyl compounds. The aryldiazenyl group was observed in the desired product from arylazosulfones, and this diazenylation reaction was achieved via a possible rearrangement process based on diaziridine ring cleavage. The scope of the protocol was investigated and a plausible mechanism was

  开发了吡啶催化的β-二酮向芳基偶氮砜的脱磺酰基加成反应，以获得二氮烯基β-二羰基化合物。在所需的芳基偶氮砜产物中观察到芳基二氮烯基，该二氮烯基化反应是通过基于二氮丙啶环裂解的可能的重排过程实现的。研究了协议的范围，并给出了合理的机制。
• S1P3 receptor antagonist
  申请人：Ohnuma Shin-ya

  公开号：US08546452B2

  公开（公告）日：2013-10-01

  The present invention relates to arylamidrazone derivatives having an antagonistic action against S1P3 receptors represented by the following formula (1) or a pharmaceutically acceptable salt thereof:

  本发明涉及具有对S1P3受体拮抗作用的芳基酰肼衍生物，其由以下公式（1）表示，或其药学上可接受的盐：
• S1P3 RECEPTOR ANTAGONIST
  申请人：Ohnuma Shin-ya

  公开号：US20090170895A1

  公开（公告）日：2009-07-02

  The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P 3 receptors and a medicine containing thereof as an active ingredient. The present invention provides an arylamidrazone derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R 1 represents a C 2 -C 8 alkyl group which may be substituted, a phenyl group which may be substituted, an aromatic heterocyclic group which may be substituted, a C 2 -C 8 alkoxy group which may be substituted, or —NR 4 R 5 (wherein R 4 and R 5 , which are identical or different, each represent a hydrogen atom or a lower alkyl group which may be substituted, or R 4 and R 5 may be joined with the adjacent nitrogen atom to form a nitrogen-containing heterocyclic ring which may be substituted); R 2 and R 3 , which are identical or different, each represent a hydrogen atom, a halogen atom, a halo-lower alkyl group, a lower alkyl group, a lower alkynyl group, a lower alkoxy group, a cyano group, a lower alkanoyl group or a lower alkylsulfonyl group; A represents a benzene ring or a heterocyclic ring; D represents a single bond or methylene; m represents an integer from 1 to 3, and n represents an integer from 1 to 5 (with the proviso that the case where R 1 is an ethoxy group, R 2 is a 2,4-dichloro group, R 3 is a hydrogen atom, A is a benzene ring, and D is methylene; and the case where R 1 is an ethoxy group, R 2 is a 2,4-dichloro group, R 3 is a hydrogen atom, a 2-methyl group, a 4-methyl group, a 4-methoxy group or a 4-ethoxy group, A is a benzene ring, and D is a single bond, are excluded).

  本发明涉及一种药物，更具体地涉及一种对S1P3受体具有拮抗作用的新型芳基酰胺脲衍生物及其作为活性成分的药物。本发明提供了下式（1）或其药学上可接受的盐所表示的芳基酰胺脲衍生物：其中R1表示可取代的C2-C8烷基，可取代的苯基，可取代的芳香杂环基，可取代的C2-C8烷氧基，或—NR4R5（其中R4和R5相同或不同，每个代表氢原子或可取代的低烷基，或R4和R5可以与相邻的氮原子连接形成可取代的含氮杂环环，其中R4和R5的情况下，它们相邻的氮原子可以连接形成可取代的含氮杂环环）；R2和R3相同或不同，每个代表氢原子，卤原子，卤代低烷基，低烷基，低炔基，低烷氧基，氰基，低烷酰基或低烷基磺酰基；A代表苯环或杂环环；D代表单键或亚甲基；m表示1到3的整数，n表示1到5的整数（但其中R1为乙氧基，R2为2,4-二氯基，R3为氢原子，A为苯环，D为亚甲基的情况和R1为乙氧基，R2为2,4-二氯基，R3为氢原子，2-甲基，4-甲基，4-甲氧基或4-乙氧基，A为苯环，D为单键的情况不包括在内）。