4-[4-(4-hydroxy-benzylidene)-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl]-benzoic acid | 77666-73-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-(4-hydroxy-benzylidene)-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl]-benzoic acid
• 英文别名: 4-[4,5-Dihydro-4-[(4-hydroxyphenyl)methylene]-3-methyl-5-oxo-1H-pyrazol-1-YL]benzoic acid；4-[(4Z)-4-[(4-hydroxyphenyl)methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
• CAS: 77666-73-0
• 化学式: C₁₈H₁₄N₂O₄
• 分子量: 322.32
• InChiKey: JWHGXMAVIMEDSS-YBEGLDIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  90.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Detection and Treatment of Schizophrenia
  申请人：Itokawa Masanari

  公开号：US20110028470A1

  公开（公告）日：2011-02-03

  The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.

  本发明提供了一种用于诊断精神分裂症的方法，以及用于该方法的精神分裂症诊断试剂或设备。本发明进一步提供了一种治疗或改善精神分裂症的药剂，该药剂对于治疗或改善精神分裂症有效。用于治疗或改善精神分裂症的药剂包含醛固定剂或醛修饰蛋白形成抑制剂作为活性成分。根据本发明的诊断精神分裂症的方法包括在受试者中测量至少一个参数，所述参数选自以下组合：（1）甘氧化酶I基因的遗传异常；（2）生物样本中甘氧化酶I的表达水平或活性；（3）蛋白质中醛化合物或经醛化合物修饰的蛋白质的量；以及（4）生物样本中吡哆醛的量。
• Stable Pigment Dispersions
  申请人：Louwet Frank

  公开号：US20080188612A1

  公开（公告）日：2008-08-07

  A pigment dispersion includes a pigment and a block copolymer having ionic aromatic monomers. The pigment dispersions can be used for manufacturing inkjet inks and for the coating of colored layers. A process for preparing the pigment dispersion is also disclosed.

  一种颜料分散液包括颜料和具有离子芳香单体的嵌段共聚物。这种颜料分散液可以用于制造喷墨墨水和彩色层的涂层。还公开了一种制备颜料分散液的过程。
• Inhibitor of protein modification products formation
  申请人：Miyata Toshio

  公开号：US20070123577A1

  公开（公告）日：2007-05-31

  [PROBLEMS] To provide a inhibitor of protein modification products formation capable of inhibiting of vitamin B6 deficiency disease as a side effect, especially a renal protective agent. [MEANS FOR SOLVING PROBLEMS] There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) (II) [wherein R1 is substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simulataneously hydrogen atoms].

  【问题】提供一种蛋白质修饰产物形成的抑制剂，能够抑制维生素B6缺乏病作为副作用，特别是一种肾脏保护剂。 【解决问题的方法】提供一种使用任何自由或盐形式的化合物作为活性成分，其中化合物的公式为(I)或(II)： （I）（II） 其中，R1是取代或未取代的芳香环；R2、R3和R4中的每一个是氢原子或一价有机基团，或者R2和R3合作形成一个缩环，或者R3和R4合作表示一个二价有机基团，但要求R3和R4不能同时为氢原子。
• Photographic silver halide materials containing dispersed light-absorbing merostyryl dyes
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0021513A1

  公开（公告）日：1981-01-07

  Light-sensitive photographic silver halide material comprising a hydrophilic colloid layer containing in dispersed state a light-absorbing merostyryl dye that corresponds to the following general formula: in which: R1 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aralkyl or substituted aralkyl, R2 is carboxy, alkoxycarbonyl, aryloxycarbonyl, carbamoyl, ureido, sulphamoyl or one of the groups represented by R1; at least one of R' and R2 being or containing carboxy or carbamoyl, R3 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, and when R3 is alkyl or alkoxy it stands in ortho or para in respect of the hydroxy group, which itself is in ortho or para in respect of the methine group, said merostyryl dye containing no group that renders the dye soluble in the hydrophilic colloid layer.

  感光照相卤化银材料，包括亲水性胶体层，该胶体层在分散状态下含有符合以下通式的吸光美洛斯基染料： 其中 R1 是氢、烷基、取代烷基、芳基、取代芳基、烷基或取代烷基、 R2 是羧基、烷氧羰基、芳氧羰基、氨基甲酰基、脲基、氨基磺酰基或 R1 所代表的基团之一； R' 和 R2 中至少有一个是或含有羧基或氨基甲酰基、 R3 是氢、C1-C4 烷基、C1-C4 烷氧基，当 R3 是烷基或烷氧基时，它与羟基为正交或对位，而羟基本身与甲 基为正交或对位、 所述美拉西丁基染料不含使染料溶于亲水胶体层的基团。
• PROTEIN MODIFIER PRODUCTION INHIBITOR
  申请人：TOKAI UNIVERSITY EDUCATIONAL SYSTEM

  公开号：EP1693369A1

  公开（公告）日：2006-08-23

  [PLOBLEMS] To provide a inhibitor of protein modification products formation capable of inhibiting of vitamin B6 deficiency disease as a side effect, especially a renal protective agent. [MEANS FOR SOLVING PROBLEMS] There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) (II) [wherein R1 is substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simulataneously hydrogen atoms].

  [问题] 提供一种能够抑制蛋白质修饰产物形成的抑制剂，作为一种副作用，它能够抑制维 生素 B6 缺乏症，特别是一种肾脏保护剂。[解决问题的方法] 本发明提供了以下式中任何一种游离或盐形式化合物作为活性成分的用途：(I) (II) [其中 R1 是取代或未取代的芳环；R2、R3 和 R4 各为氢原子或一价有机基团，或者 R2 和 R3 配合形成缩合环，或者 R3 和 R4 配合代表二价有机基团，但 R3 和 R4 不能同时为氢原子]。