(R)-1,2-O-isopropylidene-4-O-(methylthiomethyl)butane-1,2,4-triol | 159424-40-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-1,2-O-isopropylidene-4-O-(methylthiomethyl)butane-1,2,4-triol
• CAS: 159424-40-5
• 化学式: C₉H₁₈O₃S
• 分子量: 206.306
• InChiKey: FXZKWNWIFWQMSQ-MRVPVSSYSA-N

物化性质

• 沸点：
  250.1±25.0 °C(predicted)
• 密度：
  1.030±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.87
• 重原子数：
  13.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-1,2-O-isopropylidene-4-O-(methylthiomethyl)butane-1,2,4-triol 在 吡啶 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 生成 (R)-4-O-methylthiomethyl-1,2-O-ditosyl-butane-1,2,4-triol
  参考文献：
  名称：

  Synthesis and catalytic properties of an acyclic analogue of hydroxy norphos

  摘要：

  The synthesis of (S)-1,2-bis(diphenylphosphino)butane-4-ol 1 an acyclic analogue of hydroxy norphos is described, starting from L-ascorbic acid. Problems which arose during the cleavage of OH-protective groups in the presence of phosphino groups are discussed. The hydrogenation properties of the catalyst derived from the new ligand are compared with those obtained with hydroxy norphos.(1)

  DOI：

  10.1016/s0040-4020(01)89582-x
• 作为产物：
  描述：

  氯甲基甲硫醚 、 (R)-4-(2-羟乙基)-2,2-二甲基-1,3-二氧戊环 在 四丁基碘化铵 、 sodium hydride 作用下， 生成 (R)-1,2-O-isopropylidene-4-O-(methylthiomethyl)butane-1,2,4-triol
  参考文献：
  名称：

  Synthesis and catalytic properties of an acyclic analogue of hydroxy norphos

  摘要：

  The synthesis of (S)-1,2-bis(diphenylphosphino)butane-4-ol 1 an acyclic analogue of hydroxy norphos is described, starting from L-ascorbic acid. Problems which arose during the cleavage of OH-protective groups in the presence of phosphino groups are discussed. The hydrogenation properties of the catalyst derived from the new ligand are compared with those obtained with hydroxy norphos.(1)

  DOI：

  10.1016/s0040-4020(01)89582-x

文献信息

• Synthesis and catalytic properties of an acyclic analogue of hydroxy norphos
  作者：Armin Börner、Jacques Ward、Wolfgang Ruth、Jens Holz、Achim Kless、Detlef Heller、Henri B. Kagan

  DOI：10.1016/s0040-4020(01)89582-x

  日期：1994.1

  The synthesis of (S)-1,2-bis(diphenylphosphino)butane-4-ol 1 an acyclic analogue of hydroxy norphos is described, starting from L-ascorbic acid. Problems which arose during the cleavage of OH-protective groups in the presence of phosphino groups are discussed. The hydrogenation properties of the catalyst derived from the new ligand are compared with those obtained with hydroxy norphos.(1)