1-Amino-4-[3-(morpholin-4-yl)phenyl]naphthalene | 294852-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1-Amino-4-[3-(morpholin-4-yl)phenyl]naphthalene
• 英文别名: 4-(3-morpholin-4-ylphenyl)naphthalen-1-amine
• CAS: 294852-03-2
• 化学式: C₂₀H₂₀N₂O
• 分子量: 304.392
• InChiKey: BMKVWCSBWGHZRL-UHFFFAOYSA-N

物化性质

• 沸点：
  517.2±50.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Amino-4-[3-(morpholin-4-yl)phenyl]naphthalene 、 苯基(3-(叔-丁基)-1-(P-甲苯基)-1H-吡唑-5-基)氨基甲酯 以 二甲基亚砜 为溶剂， 生成 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-[4-(3-(morpholin-4-yl)phenyl)naphthalen-1-yl]urea
  参考文献：
  名称：

  New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site

  摘要：

  Discovery of the pyrazole-naphthyl urea class of p38 MAP kinase inhibitors typified by the clinical candidate BIRB 796 has encouraged further exploration of this particular scaffold. Modification to the part of the inhibitor that occupies the adenine/ ATP binding site has resulted in a new way to obtain potent inhibitors that possess favorable in vitro and in vivo properties. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.042
• 作为产物：
  描述：

  间溴苯胺 在 二乙基异丙基胺 、 三丁基氯化锡 、 叔丁基锂 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 1-Amino-4-[3-(morpholin-4-yl)phenyl]naphthalene
  参考文献：
  名称：

  New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site

  摘要：

  Discovery of the pyrazole-naphthyl urea class of p38 MAP kinase inhibitors typified by the clinical candidate BIRB 796 has encouraged further exploration of this particular scaffold. Modification to the part of the inhibitor that occupies the adenine/ ATP binding site has resulted in a new way to obtain potent inhibitors that possess favorable in vitro and in vivo properties. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.042

文献信息

• Novel carbamate and oxamide compounds
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030092702A1

  公开（公告）日：2003-05-15

  Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds. 1

  本文披露了一种新型芳香化合物，其化学式为(I)，其中G、E、W、Ar、X、Y和Z如本文所述。这些化合物可用于治疗细胞因子介导的疾病或病况，如慢性炎症性疾病。还披露了含有这些化合物的药物组合物和制备这些化合物的方法。
• Compounds useful as anti-inflammatory agents
  申请人：——

  公开号：US20020032195A1

  公开（公告）日：2002-03-14

  Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds. 1

  揭示了一种新颖的芳香化合物，其化学式为(I)，其中G、E、W、Ar、X、Y和Z。这些化合物可用于治疗涉及炎症的疾病或病理条件，如慢性炎症性疾病。还揭示了含有这些化合物的药物组合物以及制备这些化合物的方法。
• Carbamate and oxamide compounds
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US06743788B2

  公开（公告）日：2004-06-01

  Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.

  本文披露了一种新的芳香族化合物，其化学式为(I)，其中G、E、W、Ar、X、Y和Z在本文中被披露。该化合物可用于治疗细胞因子介导的疾病或病症，如慢性炎症性疾病。同时，本文还披露了包含该化合物的制药组合物以及制备该化合物的方法。
• UREA COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1381594A1

  公开（公告）日：2004-01-21
• US6608052B2
  申请人：——

  公开号：US6608052B2

  公开（公告）日：2003-08-19